Self-titration by experienced e-cigarette users: blood nicotine delivery and subjective effects

Journal article


Dawkins, LE, Kimber, CF, Doig, M, Feyerabend, C and Corcoran, O (2016). Self-titration by experienced e-cigarette users: blood nicotine delivery and subjective effects. Psychopharmacology. 233 (15), pp. 2933-2941.
AuthorsDawkins, LE, Kimber, CF, Doig, M, Feyerabend, C and Corcoran, O
Abstract

Rationale Self-titration is well documented in the tobacco literature. The extent to which e-cigarette users (vapers) self-titrate is unknown. Objective This study explored the effects of high and low nicotine strength liquid on puffing topography, nicotine delivery and subjective effects in experienced vapers. Methods Eleven experienced male vapers completed 60 minutes of ad libitum vaping under low (6 mg/mL) and high (24 mg/mL) nicotine liquid conditions in two separate sessions. Measurements included: puffing topography (puff number, puff duration, volume of liquid consumed); and changes in: plasma nicotine levels, craving, withdrawal symptoms, self-reported hit, satisfaction and adverse effects. Results Liquid consumption and puff number were higher, and puff duration longer, in the low nicotine strength condition (all ps < 0.01). The mean difference in nicotine boost from baseline in the low condition was 8.59 (7.52) ng/mL, 16.99 (11.72) ng/mL and 22.03 (16.19) ng/mL at 10, 30 and 60 minutes respectively. Corresponding values for the high condition were 33.77 (34.88) ng/mL, 35.48 (28.31) ng/mL and 43.57 (34.78) ng/mL (ps < 0.05). There were no statistically significant differences between conditions in self-reported craving, withdrawal symptoms, satisfaction, hit or adverse effects. Conclusions Vapers engaged in compensatory puffing with lower nicotine strength liquid, doubling their consumption. Whilst compensatory puffing was sufficient to reduce craving and withdrawal discomfort, self-titration was incomplete with significantly higher plasma nicotine levels in the high condition.

KeywordsNicotine; Titration; E-cigarette; Puffing topography; Compensation
Year2016
JournalPsychopharmacology
Journal citation233 (15), pp. 2933-2941
PublisherSpringer Verlag (Germany)
ISSN1432-2072
Digital Object Identifier (DOI)doi:10.1007/s00213-016-4338-2
FunderUniversity of East London
Publication dates
Print27 May 2016
Publication process dates
Deposited21 Jun 2016
Accepted18 May 2016
Accepted author manuscript
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Open
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