A pre-post pilot study of electronic cigarettes to reduce smoking in people with severe mental illness

Journal article


Hickling, L, Perez-Iglesias, R, McNeil, A, Dawkins, LE, Moxham, J, Ruffell, T, Sendt, K-V and McQuire, P (2018). A pre-post pilot study of electronic cigarettes to reduce smoking in people with severe mental illness. Psychological Medicine. 49 (6), pp. 1033-1040.
AuthorsHickling, L, Perez-Iglesias, R, McNeil, A, Dawkins, LE, Moxham, J, Ruffell, T, Sendt, K-V and McQuire, P
Abstract

Background: Smoking is the largest single contributor to poor physical health and increased mortality in people with serious mental illnesses (SMI). The aim of the study was to investigate the utility of electronic cigarettes (e-cigarettes) as a harm reduction intervention in this population. Method: Fifty tobacco smokers with a psychotic disorder were enrolled onto a 24-week pilot study (ClinicalTrials.gov: NCT02212041) investigating the efficacy of a 6-week free e-cigarette intervention to reduce smoking. Cigarette and e-cigarette use was self-reported at weekly visits, and verified using carbon monoxide tests. Psychopathology, e-cigarette acceptability and adverse effects were assessed using standardised scales. Results: There was a significant (≥50%) reduction in cigarettes consumed per day between baseline and week 6 (F(2.596,116.800)=25.878,p<0.001), and e-cigarette use was stable during this period (F(2.932,46.504)=2.023,p=0.115). These changes were verified by significant carbon monoxide reductions between these time points (F(3.335,126.633)=5.063),p=0.002). Conclusions: The provision of e-cigarettes is a potentially useful harm reduction intervention in smokers with a psychotic disorder.

Keywordspsychosis; schizophrenia; tobacco; smoking; e-cigarette; electronic cigarette; harm reduction; acceptability; 1701 Psychology; 1117 Public Health And Health Services; 1109 Neurosciences; Psychiatry
Year2018
JournalPsychological Medicine
Journal citation49 (6), pp. 1033-1040
PublisherCambridge University Press (CUP)
ISSN0033-2917
Digital Object Identifier (DOI)doi:10.1017/S0033291718001782
Publication dates
Print10 Jul 2018
Publication process dates
Deposited22 Jun 2018
Accepted14 Jun 2018
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