Relapse to smoking during unaided cessation: clinical, cognitive, and motivational predictors
Journal article
Powell, J.H., Dawkins, L., West, R., Powell, J.F. and Pickering, A. (2010). Relapse to smoking during unaided cessation: clinical, cognitive, and motivational predictors. Psychopharmacology. 212, pp. 537-549. https://doi.org/10.1007/s00213-010-1975-8
Authors | Powell, J.H., Dawkins, L., West, R., Powell, J.F. and Pickering, A. |
---|---|
Abstract | Rationale: Neurobiological models of addiction suggest that abnormalities of brain reward circuitry distort salience attribution and inhibitory control processes, which in turn contribute to high relapse rates. Objectives: To determine whether impairments of salience attribution and inhibitory control predict relapse in a pharmacologically unaided attempt at smoking cessation. Methods: 141 smokers were assessed on indices of nicotine consumption / dependence (e.g. the FTND, cigarettes per day, salivary cotinine), and three trait impulsivity measures. After overnight abstinence they completed experimental tests of cue reactivity, attentional bias to smoking cues, response to financial reward, motor impulsiveness, and response inhibition (antisaccades). They then started a quit attempt with follow-up after 7 days, 1 month, and 3 months; abstinence was verified via salivary cotinine levels $\leq$ 20ng/ml. Results: Relapse rates at each point were 52.5%, 64% and 76.3%. The strongest predictor was pre-cessation salivary cotinine; other smoking / dependence indices did not explain additional outcome variance and neither did trait impulsivity. All experimental indices except responsivity to financial reward significantly predicted one week outcome. Salivary cotinine, attentional bias to smoking cues and antisaccade errors explained unique as well as shared variance. At one and three months, salivary cotinine, motor impulsiveness and cue reactivity were all individually predictive; the effects of salivary cotinine and motor impulsiveness were additive. Conclusions: These data provide some support for the involvement of abnormal cognitive and motivational processes in sustaining smoking dependence and suggest that they might be a focus of interventions, especially in the early stages of cessation. |
Year | 2010 |
Journal | Psychopharmacology |
Journal citation | 212, pp. 537-549 |
Publisher | Springer |
Digital Object Identifier (DOI) | https://doi.org/10.1007/s00213-010-1975-8 |
Web address (URL) | http://roar.uel.ac.uk/1569/ |
Publication dates | |
12 Aug 2010 | |
Publication process dates | |
Accepted | 25 Jul 2010 |
Deposited | 27 Jul 2021 |
Accepted author manuscript | License File Access Level Open |
https://openresearch.lsbu.ac.uk/item/8x59w
Download files
Accepted author manuscript
2010_Powell_etal_Relapse_smoking.pdf | ||
License: CC BY 4.0 | ||
File access level: Open |
116
total views202
total downloads2
views this month0
downloads this month