Ultrasound Super-Resolution Imaging for the Differentiation of Thyroid Nodules: A Feasibility Study

Conference paper

Zhang, G., Vu, J., Lei, Y-M., Hu, J-R., Hu, H-M., Harput, S., Guo, Z-Z., Cui, X-W. and Ye, H-R. (2022). Ultrasound Super-Resolution Imaging for the Differentiation of Thyroid Nodules: A Feasibility Study. 2022 IEEE International Ultrasonics Symposium (IUS). Venice, Italy 10 - 13 Oct 2022 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ius54386.2022.9958286
AuthorsZhang, G., Vu, J., Lei, Y-M., Hu, J-R., Hu, H-M., Harput, S., Guo, Z-Z., Cui, X-W. and Ye, H-R.
TypeConference paper
Abstract

Super-resolution imaging technique has shown the capability to break the diffraction limit of ultrasound to image microvessels. The purpose of this study was to assess its feasibility and value in the differentiation of thyroid nodules. In this study, 24 cases of thyroid nodules were examined by B-mode, color Doppler flow imaging and contrast-enhanced ultrasound. Super-resolution imaging was conducted to depict the microvasculature with finer details. Microvascular flow rate (MFR) as well as micro-vessel density (MVD) in thyroid nodules were calculated. MFR and MVD were used to distinguish benign from malignant thyroid nodules. Pathological results were considered as the gold standard. Our findings demonstrated that SRI could visualize human thyroid nodule microvessels in finer details and obtain useful clinical information, such as MVD and MFR to aid in differential diagnosis. The results showed that the mean MFR of benign thyroid nodules was 16.76 ± 6.82 mm/s, while the mean MFR of malignant thyroid nodules was 9.86 ± 4.54 mm/s. The mean value of MVD in benign thyroid nodules was 0.78, while that in the malignant thyroid nodules was 0.59. MFR and MVD in the benign thyroid nodules were significantly higher than those in malignant thyroid nodules (p < 0.01). This study demonstrated the feasibility of ultrasound super-resolution imaging to visualize the microvessels of human thyroid nodules. Important imaging markers, such as MVD and MFR, can be obtained from SRI to provide more useful clinical information. It showed a great potential to be a new method to aid in the differential diagnosis of thyroid nodules.

Year2022
JournalIEEE International Ultrasonics Symposium, IUS
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
ISSN1948-5727
Digital Object Identifier (DOI)https://doi.org/10.1109/ius54386.2022.9958286
Accepted author manuscript
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Open
Publication dates
Online10 Oct 2022
Print10 Oct 2022
Publication process dates
Deposited17 Jan 2023
Funder/ClientImperial College London
National Natural Science Foundation of China
Hubei Provincial Health and Family Planning Commission
Wuhan University of science and technology
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Moubark, A.M., Harput, S. and Cowell, D.M.J. (2016). Plane wave imaging challenge. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728893
Enhancement of contrast and resolution of B-mode plane wave imaging (PWI) with non-linear filtered delay multiply and sum (FDMAS) beamforming
Moubark, A.M., Alomari, Z., Harput, S., Cowell, D.M.J. and Freear, S. (2016). Enhancement of contrast and resolution of B-mode plane wave imaging (PWI) with non-linear filtered delay multiply and sum (FDMAS) beamforming. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728536
Improved shear wave-front reconstruction method by aligning imaging beam angles with shear-wave polarization: Applied for shear compounding application
Hyder, S., Harput, S., Alomari, Z., Cowell, D.M.J., McLaughlan, J. and Freear, S. (2016). Improved shear wave-front reconstruction method by aligning imaging beam angles with shear-wave polarization: Applied for shear compounding application. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728536
Simultaneous trapping and imaging of microbubbles at clinically relevant flow rates
Harput, S., Nie, L., Cowell, D.M.J., Carpenter, T., Raiton, B., McLaughlan, J. and Freear, S. (2016). Simultaneous trapping and imaging of microbubbles at clinically relevant flow rates. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728393
Coupling of wideband impulses generated by granular chains into liquids for biomedical applications
Harput, S., Freear, S., Gelat, P., Saffari, N., Yang, J., Akanji, O., Thomas, P.J. and Hutchins, D.A. (2016). Coupling of wideband impulses generated by granular chains into liquids for biomedical applications. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728481
Spatial Resolution and Contrast Enhancement in Photoacoustic Imaging with Filter Delay Multiply and Sum Beamforming Technique
Alshaya, A., Harput, S., Moubark, A.M., Cowell, D.M.J., McLaughlan, J. and Freear, S. (2016). Spatial Resolution and Contrast Enhancement in Photoacoustic Imaging with Filter Delay Multiply and Sum Beamforming Technique. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728682
Specimen-agnostic guided wave inspection using recursive feedback
Adams, C., Harput, S., Cowell, D., Freear, S. and Charutz, D.M. (2016). Specimen-agnostic guided wave inspection using recursive feedback. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728811
The Effect of Boundary Conditions on Resonant Ultrasonic Spherical Chains
Akanji, O, Yang, J., Hutchins, D., Thomas, P.J., Davis, L.A.J., Harput, S., Freear, S., Gelat, P.N. and Saffari, N. (2016). The Effect of Boundary Conditions on Resonant Ultrasonic Spherical Chains. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 63 (11), pp. 1957-1966. https://doi.org/10.1109/TUFFC.2016.2576563
An adaptive array excitation scheme for the unidirectional enhancement of guided waves
Adams, C., Harput, S., Cowell, D., Carpenter, T.M., Charutz, D.M. and Freear, S. (2016). An adaptive array excitation scheme for the unidirectional enhancement of guided waves. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 64 (2), pp. 441-451. https://doi.org/10.1109/TUFFC.2016.2628100
Contrast-enhanced ultrasound imaging with chirps: Signal processing and pulse compression
Harput, S., McLaughlan, J., Cowell, D. and Freear, S. (2015). Contrast-enhanced ultrasound imaging with chirps: Signal processing and pulse compression. 2015 IEEE International Ultrasonics Symposium (IUS). Taipei, Taiwan 21 Oct - 24 Nov 2015 https://doi.org/10.1109/ULTSYM.2015.0160
Ultrasonic propagation in finite-length granular chains
Hutchins, D.A., Yang, J., Akanji, O., Thomas, P.J., Davis, L.A.J., Freear, S., Harput, S., Saffari, N. and Gelat, P. (2015). Ultrasonic propagation in finite-length granular chains. Ultrasonics. 69, pp. 215-223. https://doi.org/10.1016/j.ultras.2015.10.018
Superharmonic imaging with chirp coded excitation: filtering spectrally overlapped harmonics
Harput, S., McLaughlan, J. and Cowell, D. M. J. (2014). Superharmonic imaging with chirp coded excitation: filtering spectrally overlapped harmonics. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 61 (11), pp. 1802-1814. https://doi.org/10.1109/TUFFC.2014.006424
Ultrasonic Phased Array Device for Acoustic Imaging in Air
Harput, S. and Bozkurt, A. (2008). Ultrasonic Phased Array Device for Acoustic Imaging in Air. IEEE Sensors Journal. 8 (11), pp. 1755 - 1762. https://doi.org/10.1109/JSEN.2008.2004574