Photoacoustic Super-Resolution Imaging using Laser Activation of Low-Boiling-Point Dye-Coated Nanodroplets in vitro and in vivo
Conference paper
Zhang, G, Dunsby, C, Bamber, J, Tang, MX, Harput, S, Shah, A, Hernandez-Gil, J, Zhu, J, Christensen-Jeffries, K, Brown, J, Long, NJ and Eckersley, RJ (2019). Photoacoustic Super-Resolution Imaging using Laser Activation of Low-Boiling-Point Dye-Coated Nanodroplets in vitro and in vivo. 2019 IEEE International Ultrasonics Symposium (IUS). 06 - 09 Oct 2019 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2019.8926179
Authors | Zhang, G, Dunsby, C, Bamber, J, Tang, MX, Harput, S, Shah, A, Hernandez-Gil, J, Zhu, J, Christensen-Jeffries, K, Brown, J, Long, NJ and Eckersley, RJ |
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Type | Conference paper |
Abstract | © 2019 IEEE. In this study, a photoacoustic super-resolution imaging technique was developed through imaging the activation of Cyanine 7.5-coated phase-change nanodroplets using a preclinical photoacoustic imaging system and localizing the activated droplets. As a proof-of-concept experiment, photoacoustic images of flowing dye-coated nanodroplets in microfluidic channels were obtained with a cylindrically focused curved-array. Experimental results showed that super-resolution images can resolve the microfluidic channels which cannot be resolved by conventional beamformed images. The results also showed that the dye-coated phase-change nanodroplets can be optically activated in vivo and the activation signals can be separated from the image background by applying singular value decomposition filtering, and be used for further super-localization processing. Such nanodroplets can offer better biocompatibility, as well as more flexible and controllable droplet activation rates, with potential for super-resolution imaging of static and extravascular targets, compared to existing contrast agents used in existing localization-based photoacoustic super-resolution imaging techniques. |
Keywords | Super-Resolution; Photoacoustics; Nanodroplets; MSOT System; Laser |
Year | 2019 |
Journal | IEEE International Ultrasonics Symposium, IUS |
Publisher | Institute of Electrical and Electronics Engineers (IEEE) |
Journal citation | 2019-October, pp. 944-947 |
ISSN | 1948-5719 |
Digital Object Identifier (DOI) | https://doi.org/10.1109/ULTSYM.2019.8926179 |
Publisher's version | License File Access Level Open |
Publication dates | |
01 Oct 2019 | |
Publication process dates | |
Accepted | 06 Sep 2019 |
Deposited | 24 Mar 2020 |
ISBN | 9781728145969 |
https://openresearch.lsbu.ac.uk/item/89599
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Publisher's version
Photoacoustic Super-Resolution Imaging using Laser Activation of Low-Boiling-Point Dye-Coated Nanodroplets in vitro and in vivo.pdf | ||
License: CC BY 4.0 | ||
File access level: Open |
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