Combining Acoustic Trapping with Plane Wave Imaging for Localized Microbubble Accumulation in Large Vessels

Journal article


Nie, L., Harput, S., Cowell, D.M.J., Carpenter, T.M., Mclaughlan, J.R. and Freear, S. (2018). Combining Acoustic Trapping with Plane Wave Imaging for Localized Microbubble Accumulation in Large Vessels. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 65 (7), pp. 1193-1204.
AuthorsNie, L., Harput, S., Cowell, D.M.J., Carpenter, T.M., Mclaughlan, J.R. and Freear, S.
Abstract

The capability of accumulating microbubbles using ultrasound, could be beneficial for enhancing targeted drug delivery. When microbubbles are used to deliver a therapeutic payload, there is a need to track them, for a localized release of the payload. In this study, a method for localizing microbubble accumulation with fast image guidance is presented. A linear array transducer performed trapping of microbubble populations interleaved with plane wave imaging, through the use of a composite pulse sequence. The acoustic trap in the pressure field was created parallel with the direction of flow in a model of a vessel section. The acoustic trapping force resultant from the large gradients in the acoustic field was engendered to directly oppose the flowing microbubbles. This was demonstrated numerically with field simulations, and experimentally using an Ultrasound Array Research Platform II (UARP II). SonoVue microbubbles at clinically relevant concentrations were pumped through a tissue-mimicking flow phantom and exposed to either the acoustic trap or a control ultrasonic field composed of a single-peak acoustic radiation force beam. Under the flow condition at a shear rate of 433 s-1, the use of the acoustic trap led to lower speed estimations (p< 0.05) in the center of the acoustic field, and an enhancement of 71 ± 28% (p< 0.05) in microbubble image brightness

KeywordsAcoustic radiation force (ARF); acoustic trap; atherosclerosis; diagnostic ultrasound; microbubbles; plane wave imaging (PWI); sonothrombolysis; targeted drug delivery; ultrasound contrast agents
Year2018
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Journal citation65 (7), pp. 1193-1204
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
ISSN0885-3010
Digital Object Identifier (DOI)doi:10.1109/TUFFC.2018.2838332
Web address (URL)https://ieeexplore.ieee.org/document/8361061
FunderEngineering and Physical Sciences Research Council (EPSRC)
Publication dates
Online18 May 2018
Print01 Jul 2018
Publication process dates
Accepted14 May 2019
Deposited12 Aug 2019
Accepted author manuscript
License
CC BY 3.0
File Access Level
Open
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