High frame rate contrast enhanced ultrasound imaging for slow flow: influence of ultrasound pressure and flow rate on bubble disruption and image persistence
Journal article
Zhu, J., Lin, S., Leow, C.H., Rowland, E.M., Riemer, K., Harput, S., Weinberg, P.D. and Tang, M-X. (2019). High frame rate contrast enhanced ultrasound imaging for slow flow: influence of ultrasound pressure and flow rate on bubble disruption and image persistence. Ultrasound in Medicine and Biology. 45 (9), pp. 2456-2470. https://doi.org/10.1016/j.ultrasmedbio.2019.05.016
Authors | Zhu, J., Lin, S., Leow, C.H., Rowland, E.M., Riemer, K., Harput, S., Weinberg, P.D. and Tang, M-X. |
---|---|
Abstract | Contrast-enhanced ultrasound (CEUS) utilising microbubbles shows great potential for visualising lymphatic vessels and identifying sentinel lymph nodes (SLNs) which are valuable for axillary staging in breast cancer patients. However, current CEUS imaging techniques have limitations that affect the accurate visualisation and tracking of lymphatic vessels and SLN. (i) Tissue artefacts and bubble disruption can reduce the image contrast. (ii) Limited spatial and temporal resolution diminishes the amount of information that can be captured by CEUS. (iii) The slow lymph flow makes Doppler-based approaches less effective. This work evaluates on a lymphatic vessel phantom the use of high frame rate (HFR) CEUS for the detection of lymphatic vessels where flow is slow. Specifically, the work particularly investigates the impact of key factors in lymphatic imaging, including ultrasound pressure and flow velocity as well as probe motion during vessel tracking, on bubble disruption and image contrast. Experiments were also conducted to apply HFR CEUS imaging on vasculature in a rabbit popliteal lymph node (LN). Our results show that (i) HFR imaging and singular value decomposition (SVD) filtering can significantly reduce tissue artefacts in the phantom at high clinical frequencies; (ii) the slow flow rate within the phantom makes image contrast and signal persistence more susceptible to changes in ultrasound amplitude or mechanical index (MI), and an MI value can be chosen to reach a compromise between images contrast and bubble disruption under slow flow condition; (iii) probe motion significantly decreases image contrast of the vessel, which can be improved by applying motion correction before SVD filtering; (iv) the optical observation of the impact of ultrasound pressure on HFR CEUS further confirms the importance of optimising ultrasound amplitude and (v) vessels inside rabbit LN with blood flow less than 3 mm/s are clearly visualised. |
Year | 2019 |
Journal | Ultrasound in Medicine and Biology |
Journal citation | 45 (9), pp. 2456-2470 |
Publisher | Elsevier |
ISSN | 0301-5629 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.ultrasmedbio.2019.05.016 |
Publication dates | |
Online | 03 Jul 2019 |
Publication process dates | |
Accepted | 13 May 2019 |
Deposited | 31 Oct 2019 |
Accepted author manuscript | License File Access Level Open |
https://openresearch.lsbu.ac.uk/item/88591
Download files
Accepted author manuscript
Revised Manuscript_clean version_submission_figure.pdf | ||
License: CC BY 4.0 | ||
File access level: Open |
134
total views284
total downloads0
views this month0
downloads this month