Localisation of Multiple Non-Isolated Microbubbles with Frequency Decomposition in Super-Resolution Imaging

Conference paper

Harput, S., Christensen-Jeffries, K., Brown, J., Eckersley, R.J., Dunsby, C. and Tang, M-X. (2017). Localisation of Multiple Non-Isolated Microbubbles with Frequency Decomposition in Super-Resolution Imaging. 2017 IEEE International Ultrasonics Symposium (IUS). Washington, DC, USA 06 - 09 Sep 2019 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2017.8091553
AuthorsHarput, S., Christensen-Jeffries, K., Brown, J., Eckersley, R.J., Dunsby, C. and Tang, M-X.
TypeConference paper
Abstract

—Sub-diffraction imaging, also known as ultrasound
localization microscopy, is a novel method that can overcome the fundamental diffraction limit by localizing spatially isolated microbubbles. This method requires the use of a low concentration of microbubbles to ensure that they are spatially isolated. For in vivo microvascular imaging, especially for cancer tissue with high microvascular density, spatial isolation cannot be always achieved, since vessels are close to each other and the speed of flow is slow.
This study proposes a frequency decomposition method that
uses the polydisperse nature of commercial contrast agents
to separate spatially non-isolated microbubbles with different acoustic signatures. Zero-phase filters were applied to ensure that there is no relative phase delay between decomposed signals.Results showed that a super-resolution image after frequency decomposition can be generated with 1.4 times lower number of acquisitions.

Year2017
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
ISSN1948-5727
Digital Object Identifier (DOI)https://doi.org/10.1109/ULTSYM.2017.8091553
Web address (URL)https://ieeexplore.ieee.org/document/8091727
Accepted author manuscript
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Open
Publication dates
Print02 Nov 2017
Publication process dates
Accepted06 Aug 2017
Deposited09 Aug 2019
Web address (URL) of conference proceedingshttps://ieeexplore.ieee.org/xpl/conhome/8081728/proceeding
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https://openresearch.lsbu.ac.uk/item/87x4z

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Frequency Decomposition for US-SR_v6.pdf
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Hyder, S., Harput, S., Alomari, Z., Cowell, D.M.J., McLaughlan, J. and Freear, S. (2016). Improved shear wave-front reconstruction method by aligning imaging beam angles with shear-wave polarization: Applied for shear compounding application. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728536
Simultaneous trapping and imaging of microbubbles at clinically relevant flow rates
Harput, S., Nie, L., Cowell, D.M.J., Carpenter, T., Raiton, B., McLaughlan, J. and Freear, S. (2016). Simultaneous trapping and imaging of microbubbles at clinically relevant flow rates. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728393
Coupling of wideband impulses generated by granular chains into liquids for biomedical applications
Harput, S., Freear, S., Gelat, P., Saffari, N., Yang, J., Akanji, O., Thomas, P.J. and Hutchins, D.A. (2016). Coupling of wideband impulses generated by granular chains into liquids for biomedical applications. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728481
Spatial Resolution and Contrast Enhancement in Photoacoustic Imaging with Filter Delay Multiply and Sum Beamforming Technique
Alshaya, A., Harput, S., Moubark, A.M., Cowell, D.M.J., McLaughlan, J. and Freear, S. (2016). Spatial Resolution and Contrast Enhancement in Photoacoustic Imaging with Filter Delay Multiply and Sum Beamforming Technique. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728682
Specimen-agnostic guided wave inspection using recursive feedback
Adams, C., Harput, S., Cowell, D., Freear, S. and Charutz, D.M. (2016). Specimen-agnostic guided wave inspection using recursive feedback. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728811
The Effect of Boundary Conditions on Resonant Ultrasonic Spherical Chains
Akanji, O, Yang, J., Hutchins, D., Thomas, P.J., Davis, L.A.J., Harput, S., Freear, S., Gelat, P.N. and Saffari, N. (2016). The Effect of Boundary Conditions on Resonant Ultrasonic Spherical Chains. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 63 (11), pp. 1957-1966. https://doi.org/10.1109/TUFFC.2016.2576563
An adaptive array excitation scheme for the unidirectional enhancement of guided waves
Adams, C., Harput, S., Cowell, D., Carpenter, T.M., Charutz, D.M. and Freear, S. (2016). An adaptive array excitation scheme for the unidirectional enhancement of guided waves. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 64 (2), pp. 441-451. https://doi.org/10.1109/TUFFC.2016.2628100
Contrast-enhanced ultrasound imaging with chirps: Signal processing and pulse compression
Harput, S., McLaughlan, J., Cowell, D. and Freear, S. (2015). Contrast-enhanced ultrasound imaging with chirps: Signal processing and pulse compression. 2015 IEEE International Ultrasonics Symposium (IUS). Taipei, Taiwan 21 Oct - 24 Nov 2015 https://doi.org/10.1109/ULTSYM.2015.0160
Ultrasonic propagation in finite-length granular chains
Hutchins, D.A., Yang, J., Akanji, O., Thomas, P.J., Davis, L.A.J., Freear, S., Harput, S., Saffari, N. and Gelat, P. (2015). Ultrasonic propagation in finite-length granular chains. Ultrasonics. 69, pp. 215-223. https://doi.org/10.1016/j.ultras.2015.10.018
Superharmonic imaging with chirp coded excitation: filtering spectrally overlapped harmonics
Harput, S., McLaughlan, J. and Cowell, D. M. J. (2014). Superharmonic imaging with chirp coded excitation: filtering spectrally overlapped harmonics. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 61 (11), pp. 1802-1814. https://doi.org/10.1109/TUFFC.2014.006424
Ultrasonic Phased Array Device for Acoustic Imaging in Air
Harput, S. and Bozkurt, A. (2008). Ultrasonic Phased Array Device for Acoustic Imaging in Air. IEEE Sensors Journal. 8 (11), pp. 1755 - 1762. https://doi.org/10.1109/JSEN.2008.2004574