Simultaneous trapping and imaging of microbubbles at clinically relevant flow rates

Conference paper


Harput, S., Nie, L., Cowell, D.M.J., Carpenter, T., Raiton, B., McLaughlan, J. and Freear, S. (2016). Simultaneous trapping and imaging of microbubbles at clinically relevant flow rates. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). doi:10.1109/ULTSYM.2016.7728393
AuthorsHarput, S., Nie, L., Cowell, D.M.J., Carpenter, T., Raiton, B., McLaughlan, J. and Freear, S.
TypeConference paper
Abstract

Mechanisms for non-invasive target drug delivery using microbubbles and ultrasound have attracted growing interest. Microbubbles can be loaded with a therapeutic payload and tracked via ultrasound imaging to selectively release their payload at ultrasound-targeted locations. In this study, an ultrasonic trapping method is proposed for simultaneously imaging and controlling the location of microbubbles in flow by using acoustic radiation force. Targeted drug delivery methods are expected to benefit from the use of the ultrasonic trap, since trapping will increase the MB concentration at a desired location in human body. The ultrasonic trap was generated by using an ultrasound research system UARP II and a linear array transducer. The trap was designed asymmetrically to produces a weaker radiation force at the inlet of the trap to further facilitate microbubble entrance. A pulse sequence was generated that can switch between a long duration trapping waveform and short duration imaging waveform. High frame rate plane wave imaging was chosen for monitoring trapped microbubbles at 1 kHz. The working principle of the ultrasonic trap was explained and demonstrated in an ultrasound phantom by injecting SonoVue microbubbles flowing at 80 mL/min flow rate in a 3.5 mm diameter vessel.

© 2016, IEEE. This is an author produced version of a paper published in Ultrasonics Symposium (IUS), 2016 IEEE International. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works. Uploaded in accordance with the publisher’s self-archiving policy.

Year2016
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
ISSN1948-5727
Digital Object Identifier (DOI)doi:10.1109/ULTSYM.2016.7728393
Web address (URL)https://ieeexplore.ieee.org/document/7728393
Accepted author manuscript
License
CC BY
File Access Level
Open
Publication dates
Online03 Nov 2016
Publication process dates
Accepted21 Sep 2016
Deposited12 Aug 2019
ISBN9781467398978
Web address (URL) of conference proceedingshttps://ieeexplore.ieee.org/xpl/conhome/7589760/proceeding
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