Minimization of Nanodroplet Activation Time using Focused-Pulses for Droplet-Based Ultrasound Super-Resolution Imaging

Conference paper


Zhang, G, Harput, S, Zhu, J, Christensen-Jeffries, K, Brown, J, Leow, CH, Dunsby, C, Eckersley, RJ and Tang, MX (2019). Minimization of Nanodroplet Activation Time using Focused-Pulses for Droplet-Based Ultrasound Super-Resolution Imaging. 2019 IEEE International Ultrasonics Symposium (IUS). 06 - 09 Oct 2019 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2019.8926067
AuthorsZhang, G, Harput, S, Zhu, J, Christensen-Jeffries, K, Brown, J, Leow, CH, Dunsby, C, Eckersley, RJ and Tang, MX
TypeConference paper
Abstract

© 2019 IEEE. One of the crucial challenges in the application of ultrasound super-resolution imaging using microbubble contrast agents to the clinic is the long acquisition time. Recently acoustic wave sparsely activated localization microscopy (AWSALM) was developed to activate, image, and destroy nanodroplets to achieve ultrasound super-resolution imaging. The activation and destruction of nanodroplets using focused pulses in AWSALM can generate new localization signals without relying on flow and shows the potential to achieve faster ultrasound super-resolution. However, the technique requires optimization to achieve good activation efficiency with the minimum amount of activation time.This work investigates how the different activation strategies affect the activation time and efficiency. A range of activation sequences with different F-numbers and spacing between transmit foci are used and their activation efficiency and the data acquisition time are quantified. The results show that sweeping the focus of the activation pulse with an F-number of 0.4 and a step size of 2.5 wavelengths can generate the highest droplet activation. By using a larger or smaller spacing between consecutive focused activation beams generated lower contrast, which suggests that densely spaced activation pulses may destroy the activated nanodroplets generated by the previous activation pulse. In summary, this study demonstrates that the rate of activation of nanodroplets can be increased by optimizing the F-number and the sweep step size. This finding can inform the development of droplet-based super-resolution imaging to further minimize the data acquisition time.

KeywordsSuper-Resolution; Decafluorobutane Nanodroplets; Focused Activation; Microbubbles
Year2019
JournalIEEE International Ultrasonics Symposium, IUS
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Journal citation2019-October, pp. 372-375
ISSN1948-5719
Digital Object Identifier (DOI)https://doi.org/10.1109/ULTSYM.2019.8926067
Publisher's version
License
File Access Level
Open
Publication dates
Print01 Oct 2019
Publication process dates
Accepted06 Sep 2019
Deposited24 Mar 2020
ISBN9781728145969
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https://openresearch.lsbu.ac.uk/item/89596

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Moubark, A.M., Alomari, Z., Harput, S., Cowell, D.M.J. and Freear, S. (2016). Enhancement of contrast and resolution of B-mode plane wave imaging (PWI) with non-linear filtered delay multiply and sum (FDMAS) beamforming. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728536
Improved shear wave-front reconstruction method by aligning imaging beam angles with shear-wave polarization: Applied for shear compounding application
Hyder, S., Harput, S., Alomari, Z., Cowell, D.M.J., McLaughlan, J. and Freear, S. (2016). Improved shear wave-front reconstruction method by aligning imaging beam angles with shear-wave polarization: Applied for shear compounding application. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728536
Simultaneous trapping and imaging of microbubbles at clinically relevant flow rates
Harput, S., Nie, L., Cowell, D.M.J., Carpenter, T., Raiton, B., McLaughlan, J. and Freear, S. (2016). Simultaneous trapping and imaging of microbubbles at clinically relevant flow rates. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728393
Coupling of wideband impulses generated by granular chains into liquids for biomedical applications
Harput, S., Freear, S., Gelat, P., Saffari, N., Yang, J., Akanji, O., Thomas, P.J. and Hutchins, D.A. (2016). Coupling of wideband impulses generated by granular chains into liquids for biomedical applications. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728481
Spatial Resolution and Contrast Enhancement in Photoacoustic Imaging with Filter Delay Multiply and Sum Beamforming Technique
Alshaya, A., Harput, S., Moubark, A.M., Cowell, D.M.J., McLaughlan, J. and Freear, S. (2016). Spatial Resolution and Contrast Enhancement in Photoacoustic Imaging with Filter Delay Multiply and Sum Beamforming Technique. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728682
Specimen-agnostic guided wave inspection using recursive feedback
Adams, C., Harput, S., Cowell, D., Freear, S. and Charutz, D.M. (2016). Specimen-agnostic guided wave inspection using recursive feedback. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728811
The Effect of Boundary Conditions on Resonant Ultrasonic Spherical Chains
Akanji, O, Yang, J., Hutchins, D., Thomas, P.J., Davis, L.A.J., Harput, S., Freear, S., Gelat, P.N. and Saffari, N. (2016). The Effect of Boundary Conditions on Resonant Ultrasonic Spherical Chains. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 63 (11), pp. 1957-1966. https://doi.org/10.1109/TUFFC.2016.2576563
An adaptive array excitation scheme for the unidirectional enhancement of guided waves
Adams, C., Harput, S., Cowell, D., Carpenter, T.M., Charutz, D.M. and Freear, S. (2016). An adaptive array excitation scheme for the unidirectional enhancement of guided waves. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 64 (2), pp. 441-451. https://doi.org/10.1109/TUFFC.2016.2628100
Contrast-enhanced ultrasound imaging with chirps: Signal processing and pulse compression
Harput, S., McLaughlan, J., Cowell, D. and Freear, S. (2015). Contrast-enhanced ultrasound imaging with chirps: Signal processing and pulse compression. 2015 IEEE International Ultrasonics Symposium (IUS). Taipei, Taiwan 21 Oct - 24 Nov 2015 https://doi.org/10.1109/ULTSYM.2015.0160
Ultrasonic propagation in finite-length granular chains
Hutchins, D.A., Yang, J., Akanji, O., Thomas, P.J., Davis, L.A.J., Freear, S., Harput, S., Saffari, N. and Gelat, P. (2015). Ultrasonic propagation in finite-length granular chains. Ultrasonics. 69, pp. 215-223. https://doi.org/10.1016/j.ultras.2015.10.018
Superharmonic imaging with chirp coded excitation: filtering spectrally overlapped harmonics
Harput, S., McLaughlan, J. and Cowell, D. M. J. (2014). Superharmonic imaging with chirp coded excitation: filtering spectrally overlapped harmonics. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 61 (11), pp. 1802-1814. https://doi.org/10.1109/TUFFC.2014.006424
Ultrasonic Phased Array Device for Acoustic Imaging in Air
Harput, S. and Bozkurt, A. (2008). Ultrasonic Phased Array Device for Acoustic Imaging in Air. IEEE Sensors Journal. 8 (11), pp. 1755 - 1762. https://doi.org/10.1109/JSEN.2008.2004574