Development of Simultaneous Optical Imaging and Super-Resolution Ultrasound to Improve Microbubble Localization Accuracy
Conference paper
Harput, S. (2018). Development of Simultaneous Optical Imaging and Super-Resolution Ultrasound to Improve Microbubble Localization Accuracy. 2018 IEEE International Ultrasonics Symposium (IUS). Kobe, Japan 22 - 25 Oct 2018 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2018.8580212
Authors | Harput, S. |
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Type | Conference paper |
Abstract | © 2018 IEEE. Acoustic super-resolution (SR) has the potential to visualize microvasculature by localizing individual microbubble (MB) signals. Currently, all detected signals are processed and localized identically. However, the MB point spread function (PSF) is not independent of its surroundings. Despite accuracy on the order of microns being required, it is currently not possible to quantify error that may be introduced due to variation in the MB responses. This work combines high frame rate plane wave ultrasound acquisition with a coincident optical microscope visualizing the SR imaging of a 200 μm cellulose tube. An adjustable aperture has been introduced into the optical microscope to extend the optical depth of field over the phantom. The results showed that the introduction of the aperture enabled modest extension of the depth of field over 50 μm about the optical focus. Modelling and experimental verification found that, at a flow rate of 15 μl/min, MBs could only be detected over the top 70 μm of the tube phantom - further reducing the required depth of field. The simultaneous optical and acoustic data suggested that many fewer MBs acoustically contribute to the SR image than can be observed in the optical FOV. Investigations incorporating a ground truth, like this one, will allow sources of error to be identified, quantified and limited. |
Year | 2018 |
Publisher | Institute of Electrical and Electronics Engineers (IEEE) |
ISSN | 1948-5719 |
Digital Object Identifier (DOI) | https://doi.org/10.1109/ULTSYM.2018.8580212 |
Accepted author manuscript | License File Access Level Open |
Publication dates | |
Online | 17 Dec 2018 |
Publication process dates | |
Accepted | 22 Sep 2018 |
Deposited | 02 Sep 2019 |
https://openresearch.lsbu.ac.uk/item/87z34
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Accepted author manuscript
Development of Simultaneous Optical Imaging and Super-Resolution Ultrasound to Improve Microbubble Localization Accuracy.pdf | ||
License: CC BY 4.0 | ||
File access level: Open |
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