Characterisation of Liposome-Loaded Microbubble Populations for Subharmonic Imaging
Journal article
McLaughlan, J.R., Harput, S., Abou-Saleh, R.H., Payman, S.A., Evans, S. and Freear, S. (2016). Characterisation of Liposome-Loaded Microbubble Populations for Subharmonic Imaging. Ultrasound in Medicine and Biology. 43 (1), pp. 346-356. https://doi.org/10.1016/j.ultrasmedbio.2016.09.011
Authors | McLaughlan, J.R., Harput, S., Abou-Saleh, R.H., Payman, S.A., Evans, S. and Freear, S. |
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Abstract | Therapeutic microbubbles could make an important contribution to the diagnosis and treatment of cancer. Acoustic characterisation was performed on microfluidic generated microbubble populations that either were bare or had liposomes attached. Through the use of broadband attenuation techniques (3–8 MHz), the shell stiffness was measured to be 0.72 ± 0.01 and 0.78 ± 0.05 N/m and shell friction was 0.37 ± 0.05 and 0.74 ± 0.05 × 10−6 kg/s for bare and liposome-loaded microbubbles, respectively. Acoustic scatter revealed that liposome-loaded microbubbles had a lower subharmonic threshold, occurring from a peak negative pressure of 50 kPa, compared with 200 kPa for equivalent bare microbubbles. It was found that liposome loading had a negligible effect on the destruction threshold for this microbubble type, because at a mechanical index >0.4 (570 kPa), 80% of both populations were destroyed. |
Year | 2016 |
Journal | Ultrasound in Medicine and Biology |
Journal citation | 43 (1), pp. 346-356 |
Publisher | Elsevier |
ISSN | 0301-5629 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.ultrasmedbio.2016.09.011 |
Web address (URL) | https://linkinghub.elsevier.com/retrieve/pii/S030156291630312X |
Publication dates | |
Online | 24 Oct 2016 |
01 Jan 2017 | |
Publication process dates | |
Accepted | 08 Sep 2016 |
Deposited | 12 Aug 2019 |
Publisher's version | License File Access Level Open |
https://openresearch.lsbu.ac.uk/item/87x8w
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Publisher's version
Characterisation of Liposome-Loaded Microbubble Populations for Subharmonic Imaging.pdf | ||
License: CC BY 4.0 | ||
File access level: Open |
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