Acoustic wave sparsely-activated localization microscopy (AWSALM): super-resolution ultrasound imaging using acoustic activation and deactivation of nanodroplets

Journal article

Zhang, G., Harput, S., Lin, S., Christensen-Jeffries, K, Leow, C.H., Brown, J., Dunsby, C., Eckersley, R. and Tang, M. (2018). Acoustic wave sparsely-activated localization microscopy (AWSALM): super-resolution ultrasound imaging using acoustic activation and deactivation of nanodroplets. Applied Physics Letters. 113.
AuthorsZhang, G., Harput, S., Lin, S., Christensen-Jeffries, K, Leow, C.H., Brown, J., Dunsby, C., Eckersley, R. and Tang, M.
Abstract

Photo-activated localization microscopy (PALM) has revolutionized the field of fluorescence microscopy by breaking the diffraction limit in spatial resolution. In this study, “acoustic wave sparsely activated localization microscopy (AWSALM),” an acoustic counterpart of PALM, is developed to super-resolve structures which cannot be resolved by conventional B-mode imaging. AWSALM utilizes acoustic waves to sparsely and stochastically activate decafluorobutane nanodroplets by acoustic vaporization and to simultaneously deactivate the existing vaporized nanodroplets via acoustic destruction. In this method, activation, imaging, and deactivation are all performed using acoustic waves. Experimental results show that sub-wavelength micro-structures not resolvable by standard B-mode ultrasound images can be separated by AWSALM. This technique is flow independent and does not require a low concentration of contrast agents, as is required by current ultrasound super resolution techniques. Acoustic activation and deactivation can be controlled by adjusting the acoustic pressure, which remains well within the FDA approved safety range. In conclusion, this study shows the promise of a flow and contrast agent concentration independent super-resolution ultrasound technique which has potential to be faster and go beyond vascular imaging.

Year2018
JournalApplied Physics Letters
Journal citation113
PublisherAIP
ISSN1077-3118
Web address (URL)https://aip.scitation.org/doi/10.1063/1.5029874
Publication dates
Online02 Jul 2018
Publication process dates
Accepted09 May 2018
Deposited12 Aug 2019
Publisher's version
License
File Access Level
Open
Permalink -

https://openresearch.lsbu.ac.uk/item/87x6w

Download files

Publisher's version
Acoustic wave sparsely-activated localization microscopy (AWSALM).pdf
License: CC BY 4.0
File access level: Open

  • 197
    total views
  • 72
    total downloads
  • 1
    views this month
  • 0
    downloads this month

Export as

Related outputs

A Consensus Mechanism to Improve Prediction of Cortical Bone Properties using Ultrafast Ultrasound Acquisition
Abdelreheem, H., Grisan, E., Dryburgh, P., Peralta, L. and Harput, S. (2024). A Consensus Mechanism to Improve Prediction of Cortical Bone Properties using Ultrafast Ultrasound Acquisition. IEEE Access. https://doi.org/10.1109/ACCESS.2024.3404644
Determining the grain geometry from ultrasonic measurements of large-grained temperate ice cores
Graves, J., Lishman, B. and Harput, S. (2023). Determining the grain geometry from ultrasonic measurements of large-grained temperate ice cores. IEEE International Ultrasonics Symposium, IUS. https://doi.org/10.1109/ius51837.2023.10307539
Investigation of Ultrasonically Levitated Droplets for Sonochemistry with High-Speed Camera Observations
Aldahi, M., Khaheshi Hasankiadeh, A., Saif, N.B., Vasconez, J.F.Pr., Rajabi, H. and Harput, S. (2023). Investigation of Ultrasonically Levitated Droplets for Sonochemistry with High-Speed Camera Observations. 2023 IEEE International Ultrasonics Symposium (IUS). Montreal, QC, Canada 03 - 08 Sep 2023 IEEE. https://doi.org/10.1109/ius51837.2023.10307095
Cortical Bone Thickness Assessment from Multi-frequency Ultrasound RF Data using a Convolutional Architecture with Multi-head Attention
Sultan, H.H., Grisan, E., Dryburgh, P., Peralta, L. and Harput, S. (2023). Cortical Bone Thickness Assessment from Multi-frequency Ultrasound RF Data using a Convolutional Architecture with Multi-head Attention. 2023 IEEE International Ultrasonics Symposium (IUS). Montreal, QC, Canada 03 - 08 Sep 2023 IEEE. https://doi.org/10.1109/ius51837.2023.10307373
A human ear-inspired ultrasonic transducer (HEUT) for 3D localization of sub-wavelength scatterers
Nie, L., Toulemonde, M., Tang, M., Freear, S. and Harput, S. (2023). A human ear-inspired ultrasonic transducer (HEUT) for 3D localization of sub-wavelength scatterers. Applied Physics Letters. 123 (8). https://doi.org/10.1063/5.0152029
Nanodroplet-Based Super-Resolution Ultrasound Localization Microscopy
Zhang, G., Liao, C., Hu, J., Hu, H., Lei, Y., Harput, S. and Ye, H. (2023). Nanodroplet-Based Super-Resolution Ultrasound Localization Microscopy. ACS Sensors. 8 (9), pp. 3294-3306. https://doi.org/10.1021/acssensors.3c00418
A Human Ear-inspired Ultrasonic Transducer (HEUT) for 3-D Localization of Sub-wavelength Scatterers
Nie, L., Toulemonde, M., Tang, M-X., Freear, S. and Harput, S. (2023). A Human Ear-inspired Ultrasonic Transducer (HEUT) for 3-D Localization of Sub-wavelength Scatterers. Applied Physics Letters.
Estimation of Cortical Bone Strength Using CNN-based Regression Model
Sultan, Hossam H., Grisan, E., Peralta, L. and Harput, S. (2022). Estimation of Cortical Bone Strength Using CNN-based Regression Model. 2022 IEEE International Ultrasonics Symposium (IUS). Venice, Italy 10 - 13 Oct 2022 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ius54386.2022.9957568
Classification of Cortical Bone Thicknesses Based on RF Signal Spectral Analysis
Sultan, H.H., Grisan, E., Peralta, L. and Harput, S. (2022). Classification of Cortical Bone Thicknesses Based on RF Signal Spectral Analysis. 2022 IEEE International Ultrasonics Symposium (IUS). Venice, Italy 10 - 13 Oct 2022 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ius54386.2022.9958573
3D Localization of Scatterers with a Spiral-Shaped Acoustic Lens
Nie, L., Toulemonde, M., Tang, M-X., Freear, S. and Harput, S. (2022). 3D Localization of Scatterers with a Spiral-Shaped Acoustic Lens. 2022 IEEE International Ultrasonics Symposium (IUS). Venice, Italy 10 - 13 Oct 2022 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ius54386.2022.9958492
Ultrasound Super-Resolution Imaging for the Differentiation of Thyroid Nodules: A Feasibility Study
Zhang, G., Vu, J., Lei, Y-M., Hu, J-R., Hu, H-M., Harput, S., Guo, Z-Z., Cui, X-W. and Ye, H-R. (2022). Ultrasound Super-Resolution Imaging for the Differentiation of Thyroid Nodules: A Feasibility Study. 2022 IEEE International Ultrasonics Symposium (IUS). Venice, Italy 10 - 13 Oct 2022 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ius54386.2022.9958286
Ultrasound Super-Resolution Imaging for the Differential Diagnosis of Thyroid Nodules: A Pilot Study
Zhang, G., Yu, J., Lei, Y-M., Hu, J-R., Hu, H-M., Harput, S., Guo, Z., Cui, X-W. and Ye, H.R. (2022). Ultrasound Super-Resolution Imaging for the Differential Diagnosis of Thyroid Nodules: A Pilot Study. Frontiers in Oncology. https://doi.org/10.3389/fonc.2022.978164
Super-Resolution Ultrasound Localization Microscopy of Microvascular Structure and Flow for Distinguishing Metastatic Lymph Nodes – An Initial Human Study
Zhu, J., Zhang, C., Christensen-Jeffries, K., Zhang, G., Harput, S., Dunsby, C., Huang, P. and Tang, M. (2022). Super-Resolution Ultrasound Localization Microscopy of Microvascular Structure and Flow for Distinguishing Metastatic Lymph Nodes – An Initial Human Study. Ultraschall in der Medizin - European Journal of Ultrasound. https://doi.org/10.1055/a-1917-0016
3D Super Localized Flow with Locally and Acoustically Activated Nanodroplets and High Frame Rate Imaging Using a Matrix Array
Harput, S (2020). 3D Super Localized Flow with Locally and Acoustically Activated Nanodroplets and High Frame Rate Imaging Using a Matrix Array. IEEE IUS. ONLINE 07 - 11 Sep 2020
Detecting and Characterizing the Fabella with High Frame-Rate Ultrasound Imaging
Berthaume, M, Grisan, E and Harput, S (2020). Detecting and Characterizing the Fabella with High Frame-Rate Ultrasound Imaging. IEEE IUS. Online 07 - 11 Sep 2020
Quantitative Microvessel Analysis with 3D Super-Resolution Ultrasound and Velocity Mapping
Harput, S (2020). Quantitative Microvessel Analysis with 3D Super-Resolution Ultrasound and Velocity Mapping. IEEE IUS. Online 07 - 11 Sep 2020
Localization of a Scatterer in 3D with a Single Measurement and Single Element Transducer
Harput, S (2020). Localization of a Scatterer in 3D with a Single Measurement and Single Element Transducer. IEEE IUS. Online 07 - 11 Sep 2020
Effect of Mechanical Index on Repeated Sparse Activation of Nanodroplets in Vivo
Harput, S (2020). Effect of Mechanical Index on Repeated Sparse Activation of Nanodroplets in Vivo. IEEE IUS. Online 07 - 11 Sep 2020
Photoacoustic Super-Resolution Imaging using Laser Activation of Low-Boiling-Point Dye-Coated Nanodroplets in vitro and in vivo
Zhang, G, Dunsby, C, Bamber, J, Tang, MX, Harput, S, Shah, A, Hernandez-Gil, J, Zhu, J, Christensen-Jeffries, K, Brown, J, Long, NJ and Eckersley, RJ (2019). Photoacoustic Super-Resolution Imaging using Laser Activation of Low-Boiling-Point Dye-Coated Nanodroplets in vitro and in vivo. 2019 IEEE International Ultrasonics Symposium (IUS). 06 - 09 Oct 2019 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2019.8926179
Minimization of Nanodroplet Activation Time using Focused-Pulses for Droplet-Based Ultrasound Super-Resolution Imaging
Zhang, G, Harput, S, Zhu, J, Christensen-Jeffries, K, Brown, J, Leow, CH, Dunsby, C, Eckersley, RJ and Tang, MX (2019). Minimization of Nanodroplet Activation Time using Focused-Pulses for Droplet-Based Ultrasound Super-Resolution Imaging. 2019 IEEE International Ultrasonics Symposium (IUS). 06 - 09 Oct 2019 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2019.8926067
Acoustic Wave Sparsely-Activated Localization Microscopy (AWSALM): In Vivo Fast Ultrasound Super-Resolution Imaging using Nanodroplets
Zhang, G, Weinberg, P, Dunsby, C, Tang, MX, Harput, S, Toulemonde, M, Broughton-Venner, J, Zhu, J, Riemer, K, Christensen-Jeffries, K, Brown, J and Eckersley, RJ (2019). Acoustic Wave Sparsely-Activated Localization Microscopy (AWSALM): In Vivo Fast Ultrasound Super-Resolution Imaging using Nanodroplets. 2019 IEEE International Ultrasonics Symposium (IUS). 06 - 09 Oct 2019 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2019.8926069
Activation and 3D Imaging of Phase-change Nanodroplet Contrast Agents with a 2D Ultrasound Probe
Harput, S, Zhang, G, Toulemonde, M, Zhu, J, Christensen-Jeffries, K, Brown, J, Eckersley, RJ, Dunsby, C and Tang, MX (2019). Activation and 3D Imaging of Phase-change Nanodroplet Contrast Agents with a 2D Ultrasound Probe. 2019 IEEE International Ultrasonics Symposium (IUS). 06 - 09 Oct 2019 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2019.8925892
Poisson Statistical Model of Ultrasound Super-Resolution Imaging Acquisition Time
Christensen-Jeffries, K., Brown, J., Harput, S., Zhang, G., Zhu, J., Tang, M-X., Dunsby, C. and Eckersley, R.J. (2019). Poisson Statistical Model of Ultrasound Super-Resolution Imaging Acquisition Time. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. https://doi.org/10.1109/tuffc.2019.2916603
High frame rate contrast enhanced ultrasound imaging for slow flow: influence of ultrasound pressure and flow rate on bubble disruption and image persistence
Zhu, J., Lin, S., Leow, C.H., Rowland, E.M., Riemer, K., Harput, S., Weinberg, P.D. and Tang, M-X. (2019). High frame rate contrast enhanced ultrasound imaging for slow flow: influence of ultrasound pressure and flow rate on bubble disruption and image persistence. Ultrasound in Medicine and Biology. 45 (9), pp. 2456-2470. https://doi.org/10.1016/j.ultrasmedbio.2019.05.016
Super resolution ultrasound image filtering with machine learning to reduce the localization error
Harput, S., Fong, L.H., Stanziola, A., Zhang, G., Toulemonde, M., Zhou, J., Christensen-Jeffries, K., Brown, J., Eckersley, R., Grisan, E., Dunsby, C. and Tang, M. (2019). Super resolution ultrasound image filtering with machine learning to reduce the localization error. IEEE International Ultrasonics Symposium 2019. Glasgow 09 2009 - 06 Oct 2019 Institute of Electrical and Electronics Engineers (IEEE).
High frame rate tri-plane echocardiography with spiral arrays: from simulation to real-time implementation
Ramalli, A., Harput, S., Bizy, S., Boni, E., Eckersley, R.J., Tortoli, P. and D'hooge, J. (2019). High frame rate tri-plane echocardiography with spiral arrays: from simulation to real-time implementation. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 67 (1). https://doi.org/10.1109/TUFFC.2019.2940289
3-D Super-Resolution Ultrasound Imaging with a 2-D Sparse Array
Harput, S., Christensen-Jeffries, K., Ramalli, A., Brown, J., Zhu, J., Zhang, G., Leow, C-H., Toulemonde, M., Boni, E., Tortoli, P., Eckersley, R.J., Dunsby, C. and Tang, M-X. (2019). 3-D Super-Resolution Ultrasound Imaging with a 2-D Sparse Array. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 67 (2), pp. 269-277. https://doi.org/10.1109/TUFFC.2019.2943646
3D Super-Resolution US Imaging of Rabbit Lymph Node Vasculature in Vivo by Using Microbubbles
Zhu, J., Rowland, E.M., Harput, S., Riemer, K., Leow, C.H., Clark, B., Lim, A., Christensen-Jeffries K, Zhang, G., Brown, J., Dunsby, C., Eckerslet, R.J., Weinberg, P.D. and Tang, M.X (2019). 3D Super-Resolution US Imaging of Rabbit Lymph Node Vasculature in Vivo by Using Microbubbles. Radiology. 291 (3), pp. 642-650. https://doi.org/10.1148/radiol.2019182593
Investigation of Microbubble Detection Methods for Super-Resolution Imaging of Microvasculature
Brown, J., Christensen-Jeffries, K., Harput, S., Zhang, G., Zhu, J., Dunsby, C., Tang, M-X. and Eckersley, R.J. (2019). Investigation of Microbubble Detection Methods for Super-Resolution Imaging of Microvasculature. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 66 (4), pp. 676-691. https://doi.org/10.1109/TUFFC.2019.2894755
Fast acoustic wave sparsely activated localization microscopy (fast-AWSALM): ultrasound super-resolution using plane-wave activation of nanodroplets
Zhang, G., Harput, S., Hu, H., Christensen-Jeffries, K., Zhu, J., Brown, J., Leow, C.H., Eckersley, R., Dunsby, R. and Tang, M-X. (2019). Fast acoustic wave sparsely activated localization microscopy (fast-AWSALM): ultrasound super-resolution using plane-wave activation of nanodroplets. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 66 (6), pp. 1039-1046. https://doi.org/10.1109/TUFFC.2019.2906496
3D Ultrasound Image Guidance and Therapy Through the Rib Cage with a Therapeutic Random Phased Array
Zubair, M., Harput, S. and Dickinson, R. J. (2018). 3D Ultrasound Image Guidance and Therapy Through the Rib Cage with a Therapeutic Random Phased Array. 2018 IEEE International Ultrasonics Symposium (IUS). Kobe, Japan 22 - 25 Oct 2018 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2018.8579835
New Denoising Unsharp Masking Method for Improved Intima Media Thickness Measurements with Active Contour Segmentation
Moubark, A.M., Cowell, D.M.J., Harput, S. and Freear, S. (2018). New Denoising Unsharp Masking Method for Improved Intima Media Thickness Measurements with Active Contour Segmentation. 2018 IEEE International Ultrasonics Symposium (IUS). Kobe, Japan 22 - 25 Oct 2018 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2018.8579733
Fast Acoustic Wave Sparsely Activated Localization Microscopy (Fast-AWSALM) Using Octafluoropropane N Anodroplets
Zhang, G., Harput, S., Hu, H., Christensen-Jeffries K, Zhu, J., Brown, J., Leow, C.H., Dunsby, C., Eckersley, R.J. and Tang, M.X. (2018). Fast Acoustic Wave Sparsely Activated Localization Microscopy (Fast-AWSALM) Using Octafluoropropane N Anodroplets. 2018 IEEE International Ultrasonics Symposium (IUS). Kobe, Japan 22 - 25 Oct 2018 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2018.8580192
Development of Simultaneous Optical Imaging and Super-Resolution Ultrasound to Improve Microbubble Localization Accuracy
Harput, S. (2018). Development of Simultaneous Optical Imaging and Super-Resolution Ultrasound to Improve Microbubble Localization Accuracy. 2018 IEEE International Ultrasonics Symposium (IUS). Kobe, Japan 22 - 25 Oct 2018 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2018.8580212
3D in Vitro Ultrasound Super-Resolution Imaging Using a Clinical System
Christensen-Jeffries, K, Harput, S., Brown, J., Zhang, G., Zhu, J., Tang, M.X., Dunsby, C. and Eckersley, R. (2018). 3D in Vitro Ultrasound Super-Resolution Imaging Using a Clinical System. 2018 IEEE International Ultrasonics Symposium (IUS). Kobe, Japan 22 - 25 Oct 2018 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2018.8580144
Combining Acoustic Trapping with Plane Wave Imaging for Localized Microbubble Accumulation in Large Vessels
Nie, L., Harput, S., Cowell, D.M.J., Carpenter, T.M., Mclaughlan, J.R. and Freear, S. (2018). Combining Acoustic Trapping with Plane Wave Imaging for Localized Microbubble Accumulation in Large Vessels. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 65 (7), pp. 1193-1204. https://doi.org/10.1109/TUFFC.2018.2838332
Two-stage motion correction for super-resolution ultrasound imaging in human lower limb
Harput, S., Christensen-Jeffries, K., Brown, J., Yuanwei, L., Williams, K.J., Davies, A.H., Eckersley, R., Dunsby, C.W. and Tang, M. (2018). Two-stage motion correction for super-resolution ultrasound imaging in human lower limb. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 65 (5), pp. 803-814. https://doi.org/10.1109/TUFFC.2018.2824846
3-D super-resolution ultrasound (SR-US) imaging using a 2-D sparse array with high volumetric imaging rate
Harput, S., Christensen-Jeffries, K., Brown, J., Zhu, J., Zhang, G., Leow, C.H., Toulemonde, M., Ramalli, A., Boni, E., Tortoli, P., Eckersley, R.J., Dunsby, C. and Tang, M. (2018). 3-D super-resolution ultrasound (SR-US) imaging using a 2-D sparse array with high volumetric imaging rate. 2018 IEEE International Ultrasonics Symposium (IUS). Kobe, Japan 22 - 25 Oct 2018 Institute of Electrical and Electronics Engineers (IEEE).
3-D motion correction for volumetric super-resolution ultrasound (SR-US) imaging
Harput, S., Christensen-Jeffries, K, Brown, J., Zhu, J., Zhang, G., Eckersley, R.J., Dunsby C. and Tang, M. (2018). 3-D motion correction for volumetric super-resolution ultrasound (SR-US) imaging. 2018 IEEE International Ultrasonics Symposium (IUS). Kobe, Japan 22 - 25 Oct 2018 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2018.8580145
New improved unsharp masking methods compatible with ultrasound B-mode imaging
Moubark, AM, Carpenter, TM, Cowell, DMJ, Harput, S and Freear, S (2017). New improved unsharp masking methods compatible with ultrasound B-mode imaging. 2017 IEEE International Ultrasonics Symposium (IUS). 06 - 09 Sep 2017 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2017.8092244
High frame rate contrast enhanced ultrasound imaging of lymphatic vessel phantom
Zhu, J, Lin, S, Harput, S, Toulemonde, M, Leow, CH and Tang, MX (2017). High frame rate contrast enhanced ultrasound imaging of lymphatic vessel phantom. 2017 IEEE International Ultrasonics Symposium (IUS). 06 - 09 Sep 2017 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2017.8092326
A phase velocity filter for the measurement of lamb wave dispersion
Adams, C., Harput, S., Cowell, D. and Freear, S. (2017). A phase velocity filter for the measurement of lamb wave dispersion. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728797
The dynamic excitation of a granular chain: Contact mechanics finite element analysis and experimental validation
Gélat, P, Yang, J., Akanji, O., Thomas, P.J., Hutchins, D., Harput, S., Freear, S. and Saffari, N. (2017). The dynamic excitation of a granular chain: Contact mechanics finite element analysis and experimental validation. The Journal of the Acoustical Society of America. https://doi.org/10.1121/1.4983466
Acoustic microbubble trapping in blood mimicking fluid
Nie, L., Harput, S., McLaughlan, J.R., Cowell, D.M.J., Carpenter, T. and Freear, S. (2017). Acoustic microbubble trapping in blood mimicking fluid. 2017 IEEE International Ultrasonics Symposium (IUS). Washington, DC, USA 06 - 09 Sep 2019 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2017.8092590
Elevation resolution enhancement in 3D photoacoustic imaging using FDMAS beamforming
Alshaya, A., Harput, S., Cowell, D.M.J., Carpenter, T., McLaughlan, J. and Freear, S. (2017). Elevation resolution enhancement in 3D photoacoustic imaging using FDMAS beamforming. 2017 IEEE International Ultrasonics Symposium (IUS). Washington, DC, USA 06 - 09 Sep 2019 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2017.8092412
Microbubble Axial Localization Errors in Ultrasound Super-Resolution Imaging
Christensen-Jeffries, K, Harput, S., Brown, J., Wells, P.N.T., Aljabar, P., Dunsby, C.W., Tang, M. and Eckersley, R.J. (2017). Microbubble Axial Localization Errors in Ultrasound Super-Resolution Imaging. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 64 (11), p. 2017. https://doi.org/10.1109/TUFFC.2017.2741067
Generation of ultrasound pulses in water using granular chains with a finite matching layer
Harput, S., McLaughlan, J., Cowell, D.M.J., Gelat, P., Saffari, N., Yang, J., Akanji, O., Thomas, P.J, Hutchins, D.A. and Freear, S. (2017). Generation of ultrasound pulses in water using granular chains with a finite matching layer. Physical Review Applied. 8 (054032). https://doi.org/10.1103/PhysRevApplied.8.054032
Two Stage Sub-Wavelength Motion Correction in Human Microvasculature for CEUS Imaging
Harput, S., Christensen-Jeffries, K., Li, Y., Brown, J., Eckersley, R.J., Dunsby, C. and Tang, M-X. (2017). Two Stage Sub-Wavelength Motion Correction in Human Microvasculature for CEUS Imaging. 2017 IEEE International Ultrasonics Symposium (IUS). Washington, DC, USA 06 - 09 Sep 2019 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2017.8091703
Ultrasound Super-Resolution with Microbubble Contrast Agents
Harput, S., Christensen-Jeffries, K, Brown, J., Eckersley, R.J., Dunsby, C. and Tan, M-X. (2017). Ultrasound Super-Resolution with Microbubble Contrast Agents. IEEE SENSORS. Glasgow, UK 29 Oct - 01 Nov 2017 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ICSENS.2017.8234244
Localisation of Multiple Non-Isolated Microbubbles with Frequency Decomposition in Super-Resolution Imaging
Harput, S., Christensen-Jeffries, K., Brown, J., Eckersley, R.J., Dunsby, C. and Tang, M-X. (2017). Localisation of Multiple Non-Isolated Microbubbles with Frequency Decomposition in Super-Resolution Imaging. 2017 IEEE International Ultrasonics Symposium (IUS). Washington, DC, USA 06 - 09 Sep 2019 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2017.8091553
Analysis of solitary wave impulses in granular chains using ultrasonic excitation
Yang, J., Hutchins, D.A., Akanji, O., Thomas, P.J., Davis, L.A.J., Harput, S., Gelat, P., Freear, S. and Saffari, N. (2016). Analysis of solitary wave impulses in granular chains using ultrasonic excitation. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 93 (063001). https://doi.org/10.1103/PhysRevE.93.063002
Performance of Switched Mode Arbitrary Excitation using Harmonic Reduction Pulse Width Modulation (HRPWM) in Array Imaging Applications
Cowell, D.M.J., Carpenter, T., Smith, P., Adams, C., Harput, S. and Freear, S. (2016). Performance of Switched Mode Arbitrary Excitation using Harmonic Reduction Pulse Width Modulation (HRPWM) in Array Imaging Applications. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728816
The dynamic excitation of a granular chain for biomedical ultrasound applications: contact mechanics finite element analysis and validation
Gelat, P., Yang, J., Thomas, P.J., Hutchins, D.A., Akanji, O., Davis, L.A.J., Freear, S., Harput, S. and Saffari, N. (2016). The dynamic excitation of a granular chain for biomedical ultrasound applications: contact mechanics finite element analysis and validation. Journal of Physics: Conference Series. 684 (1). https://doi.org/10.1088/1742-6596/684/1/012005
Characterisation of Liposome-Loaded Microbubble Populations for Subharmonic Imaging
McLaughlan, J.R., Harput, S., Abou-Saleh, R.H., Payman, S.A., Evans, S. and Freear, S. (2016). Characterisation of Liposome-Loaded Microbubble Populations for Subharmonic Imaging. Ultrasound in Medicine and Biology. 43 (1), pp. 346-356. https://doi.org/10.1016/j.ultrasmedbio.2016.09.011
Velocity estimation error reduction in stenosis areas using a correlation correction method
Nie, L., Harput, S., Cowell, D.M.J. and Freear, S. (2016). Velocity estimation error reduction in stenosis areas using a correlation correction method. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728627
Clutter noise reduction in B-Mode image through mapping and clustering signal energy for better cyst classification
Moubark, A.M., Harput, S., Cowell, D.M.J. and Freear, S. (2016). Clutter noise reduction in B-Mode image through mapping and clustering signal energy for better cyst classification. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728860
Plane wave imaging challenge
Moubark, A.M., Harput, S. and Cowell, D.M.J. (2016). Plane wave imaging challenge. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728893
Enhancement of contrast and resolution of B-mode plane wave imaging (PWI) with non-linear filtered delay multiply and sum (FDMAS) beamforming
Moubark, A.M., Alomari, Z., Harput, S., Cowell, D.M.J. and Freear, S. (2016). Enhancement of contrast and resolution of B-mode plane wave imaging (PWI) with non-linear filtered delay multiply and sum (FDMAS) beamforming. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728536
Improved shear wave-front reconstruction method by aligning imaging beam angles with shear-wave polarization: Applied for shear compounding application
Hyder, S., Harput, S., Alomari, Z., Cowell, D.M.J., McLaughlan, J. and Freear, S. (2016). Improved shear wave-front reconstruction method by aligning imaging beam angles with shear-wave polarization: Applied for shear compounding application. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728536
Simultaneous trapping and imaging of microbubbles at clinically relevant flow rates
Harput, S., Nie, L., Cowell, D.M.J., Carpenter, T., Raiton, B., McLaughlan, J. and Freear, S. (2016). Simultaneous trapping and imaging of microbubbles at clinically relevant flow rates. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728393
Coupling of wideband impulses generated by granular chains into liquids for biomedical applications
Harput, S., Freear, S., Gelat, P., Saffari, N., Yang, J., Akanji, O., Thomas, P.J. and Hutchins, D.A. (2016). Coupling of wideband impulses generated by granular chains into liquids for biomedical applications. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728481
Spatial Resolution and Contrast Enhancement in Photoacoustic Imaging with Filter Delay Multiply and Sum Beamforming Technique
Alshaya, A., Harput, S., Moubark, A.M., Cowell, D.M.J., McLaughlan, J. and Freear, S. (2016). Spatial Resolution and Contrast Enhancement in Photoacoustic Imaging with Filter Delay Multiply and Sum Beamforming Technique. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728682
Specimen-agnostic guided wave inspection using recursive feedback
Adams, C., Harput, S., Cowell, D., Freear, S. and Charutz, D.M. (2016). Specimen-agnostic guided wave inspection using recursive feedback. 2016 IEEE International Ultrasonics Symposium (IUS). Tours, France 18 - 21 Sep 2016 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2016.7728811
The Effect of Boundary Conditions on Resonant Ultrasonic Spherical Chains
Akanji, O, Yang, J., Hutchins, D., Thomas, P.J., Davis, L.A.J., Harput, S., Freear, S., Gelat, P.N. and Saffari, N. (2016). The Effect of Boundary Conditions on Resonant Ultrasonic Spherical Chains. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 63 (11), pp. 1957-1966. https://doi.org/10.1109/TUFFC.2016.2576563
An adaptive array excitation scheme for the unidirectional enhancement of guided waves
Adams, C., Harput, S., Cowell, D., Carpenter, T.M., Charutz, D.M. and Freear, S. (2016). An adaptive array excitation scheme for the unidirectional enhancement of guided waves. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 64 (2), pp. 441-451. https://doi.org/10.1109/TUFFC.2016.2628100
Contrast-enhanced ultrasound imaging with chirps: Signal processing and pulse compression
Harput, S., McLaughlan, J., Cowell, D. and Freear, S. (2015). Contrast-enhanced ultrasound imaging with chirps: Signal processing and pulse compression. 2015 IEEE International Ultrasonics Symposium (IUS). Taipei, Taiwan 21 Oct - 24 Nov 2015 https://doi.org/10.1109/ULTSYM.2015.0160
Ultrasonic propagation in finite-length granular chains
Hutchins, D.A., Yang, J., Akanji, O., Thomas, P.J., Davis, L.A.J., Freear, S., Harput, S., Saffari, N. and Gelat, P. (2015). Ultrasonic propagation in finite-length granular chains. Ultrasonics. 69, pp. 215-223. https://doi.org/10.1016/j.ultras.2015.10.018
Superharmonic imaging with chirp coded excitation: filtering spectrally overlapped harmonics
Harput, S., McLaughlan, J. and Cowell, D. M. J. (2014). Superharmonic imaging with chirp coded excitation: filtering spectrally overlapped harmonics. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 61 (11), pp. 1802-1814. https://doi.org/10.1109/TUFFC.2014.006424
Ultrasonic Phased Array Device for Acoustic Imaging in Air
Harput, S. and Bozkurt, A. (2008). Ultrasonic Phased Array Device for Acoustic Imaging in Air. IEEE Sensors Journal. 8 (11), pp. 1755 - 1762. https://doi.org/10.1109/JSEN.2008.2004574