Evaluation of bioprosthetic heart valve failure using a matrix-fibril shear stress transfer approach

Journal article


Anssari-Benam, A, Barber, AH and Bucchi, A (2016). Evaluation of bioprosthetic heart valve failure using a matrix-fibril shear stress transfer approach. Journal of Materials Science: Materials in Medicine. 27 (2). https://doi.org/10.1007/s10856-015-5657-2
AuthorsAnssari-Benam, A, Barber, AH and Bucchi, A
Abstract

A matrix-fibril shear stress transfer approach is devised and developed in this paper to analyse the primary biomechanical factors which initiate the structural degeneration of the bioprosthetic heart valves (BHVs). Using this approach, the critical length of the collagen fibrils l c and the interface shear acting on the fibrils in both BHV and natural aortic valve (AV) tissues under physiological loading conditions are calculated and presented. It is shown that the required critical fibril length to provide effective reinforcement to the natural AV and the BHV tissue is l c = 25.36 µm and l c = 66.81 µm, respectively. Furthermore, the magnitude of the required shear force acting on fibril interface to break a cross-linked fibril in the BHV tissue is shown to be 38 µN, while the required interfacial force to break the bonds between the fibril and the surrounding extracellular matrix is 31 µN. Direct correlations are underpinned between these values and the ultimate failure strength and the failure mode of the BHV tissue compared with the natural AV, and are verified against the existing experimental data. The analyses presented in this paper explain the role of fibril interface shear and critical length in regulating the biomechanics of the structural failure of the BHVs, for the first time. This insight facilitates further understanding into the underlying causes of the structural degeneration of the BHVs in vivo.

Keywords0903 Biomedical Engineering; 0912 Materials Engineering; Biomedical Engineering
Year2016
JournalJournal of Materials Science: Materials in Medicine
Journal citation27 (2)
PublisherSpringer Verlag
ISSN0957-4530
Digital Object Identifier (DOI)https://doi.org/10.1007/s10856-015-5657-2
Publication dates
Print01 Feb 2016
Publication process dates
Deposited21 Aug 2018
Accepted29 Dec 2015
Accepted author manuscript
License
File Access Level
Open
Additional information

This is the accepted author manuscript for an article published by Springer Verlag in the Journal of Materials Science: Materials in Medicine. The full version is available online at: https://link.springer.com/article/10.1007/s10856-015-5657-2

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