Biomimetic generation of the strongest known biomaterial found in limpet tooth.

Journal article

Rumney, R., Robson, S., Kao, A., Barbu, E., Bozycki, L., Smith, J., Cragg, S., Couceiro, F., Parwani, R., Tozzi, G., Stuer, M., Barber, Asa H, Ford, A. and Górecki, D. (2022). Biomimetic generation of the strongest known biomaterial found in limpet tooth. Nature Communications. 13 (1), p. 3753. https://doi.org/10.1038/s41467-022-31139-0
AuthorsRumney, R., Robson, S., Kao, A., Barbu, E., Bozycki, L., Smith, J., Cragg, S., Couceiro, F., Parwani, R., Tozzi, G., Stuer, M., Barber, Asa H, Ford, A. and Górecki, D.
AbstractThe biomaterial with the highest known tensile strength is a unique composite of chitin and goethite (α-FeO(OH)) present in teeth from the Common Limpet (Patella vulgata). A biomimetic based on limpet tooth, with corresponding high-performance mechanical properties is highly desirable. Here we report on the replication of limpet tooth developmental processes ex vivo, where isolated limpet tissue and cells in culture generate new biomimetic structures. Transcriptomic analysis of each developmental stage of the radula, the organ from which limpet teeth originate, identifies sequential changes in expression of genes related to chitin and iron processing. We quantify iron and chitin metabolic processes in the radula and grow isolated radula cells in vitro. Bioinspired material can be developed with electrospun chitin mineralised by conditioned media from cultured radula cells. Our results inform molecular processes behind the generation of limpet tooth and establish a platform for development of a novel biomimetic with comparable properties.
KeywordsTooth; Animals; Iron; Chitin; Biocompatible Materials; Biomimetics; Gastropoda
Year2022
JournalNature Communications
Journal citation13 (1), p. 3753
PublisherNature Research (part of Springer Nature)
ISSN2041-1723
Digital Object Identifier (DOI)https://doi.org/10.1038/s41467-022-31139-0
Web address (URL)https://www.nature.com/articles/s41467-022-31139-0
Publication dates
Online07 Jul 2022
Print01 Jul 2022
Publication process dates
Accepted01 Jun 2022
Deposited22 Aug 2022
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Open
LicenseCC BY
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