Morphological and Mechanical Biomimetic Bone Structures

Journal article


Parwani, R, Curto, M, Kao, AP, Rowley, PJ, Pani, M, Tozzi, G and Barber, AH (2016). Morphological and Mechanical Biomimetic Bone Structures. ACS Biomaterials Science & Engineering. 3 (11), pp. 2761-2767.
AuthorsParwani, R, Curto, M, Kao, AP, Rowley, PJ, Pani, M, Tozzi, G and Barber, AH
Abstract

Cortical bone is an example of a mineralized tissue containing a compositional distribution of hard and soft phases in 3-dimensional space for mechanical function. X-ray computed tomography (XCT) is able to describe this compositional and morphological complexity but methods to provide a physical output with comparable mechanical function is lacking. A workflow is presented here to establish a method of using high contrast XCT to establish a virtual model of cortical bone that is manufactured using a multiple material capable 3D printer. Resultant 3D printed structures were produced based on more and less remodelled bone designs exhibiting a range of secondary osteon density. Variation in resultant mechanical properties of the 3D printed composite structures for each bone design was achieved using a combination of material components and reasonable prediction of elastic modulus provided using a Hashin-Shtrikman approach. The ability to 3D print composite structures using high contrast XCT to distinguish between compositional phases in a biological structure promises improved anatomical models as well as next-generation mechano-mimetic implants.

Year2016
JournalACS Biomaterials Science & Engineering
Journal citation3 (11), pp. 2761-2767
PublisherAmerican Chemical Society
ISSN2373-9878
Digital Object Identifier (DOI)doi:10.1021/acsbiomaterials.6b00652
Publication dates
Print19 Dec 2016
Publication process dates
Deposited21 Aug 2018
Accepted19 Dec 2016
Accepted author manuscript
License
CC BY-NC 4.0
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https://openresearch.lsbu.ac.uk/item/8710x

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