Additive Manufacturing and Physicomechanical Characteristics of PEGDA Hydrogels: Recent Advances and Perspective for Tissue Engineering
Journal article
Khalili, M.H., Zhang, R., Wilson, S., Goel, S., Impey, S.A. and Aria, A.I. (2023). Additive Manufacturing and Physicomechanical Characteristics of PEGDA Hydrogels: Recent Advances and Perspective for Tissue Engineering. Polymers. 15 (10), p. 2341. https://doi.org/10.3390/polym15102341
Authors | Khalili, M.H., Zhang, R., Wilson, S., Goel, S., Impey, S.A. and Aria, A.I. |
---|---|
Abstract | In this brief review, we discuss the recent advancements in using poly(ethylene glycol) diacrylate (PEGDA) hydrogels for tissue engineering applications. PEGDA hydrogels are highly attractive in biomedical and biotechnology fields due to their soft and hydrated properties that can replicate living tissues. These hydrogels can be manipulated using light, heat, and cross-linkers to achieve desirable functionalities. Unlike previous reviews that focused solely on material design and fabrication of bioactive hydrogels and their cell viability and interactions with the extracellular matrix (ECM), we compare the traditional bulk photo-crosslinking method with the latest three-dimensional (3D) printing of PEGDA hydrogels. We present detailed evidence combining the physical, chemical, bulk, and localized mechanical characteristics, including their composition, fabrication methods, experimental conditions, and reported mechanical properties of bulk and 3D printed PEGDA hydrogels. Furthermore, we highlight the current state of biomedical applications of 3D PEGDA hydrogels in tissue engineering and organ-on-chip devices over the last 20 years. Finally, we delve into the current obstacles and future possibilities in the field of engineering 3D layer-by-layer (LbL) PEGDA hydrogels for tissue engineering and organ-on-chip devices. |
Year | 2023 |
Journal | Polymers |
Journal citation | 15 (10), p. 2341 |
Publisher | MDPI |
ISSN | 2073-4360 |
Digital Object Identifier (DOI) | https://doi.org/10.3390/polym15102341 |
Web address (URL) | https://www.mdpi.com/2073-4360/15/10/2341 |
Publication dates | |
17 May 2023 | |
Publication process dates | |
Accepted | 12 May 2023 |
Deposited | 22 May 2023 |
Publisher's version | License File Access Level Open |
https://openresearch.lsbu.ac.uk/item/94095
Download files
99
total views104
total downloads1
views this month0
downloads this month