Critical Review of Nanopillar-Based Mechanobactericidal Systems
Journal article
Hawi, Sara, Goel, S., Kumar, V., Pearce, Oliver, Ayre, Wayne Nishio and Ivanova, E. (2022). Critical Review of Nanopillar-Based Mechanobactericidal Systems. ACS Applied Nano Materials. 5 (1), pp. 1-17. https://doi.org/10.1021/acsanm.1c03045
Authors | Hawi, Sara, Goel, S., Kumar, V., Pearce, Oliver, Ayre, Wayne Nishio and Ivanova, E. |
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Abstract | The rise of multidrug resistant bacteria is the biggest threat to human health globally as described by the World Health Organization (WHO). Mechano-bactericidal surfaces provides a sustainable approach to address this concern by eradicating pathogens, especially bacteria, “right-at-the-point” of first contacting the surface. However, the lack of a “design to manufacture” approach due to our limited understanding of the mechano-bactericidal mechanism has impeded engineering optimization to develop scalable exploitation routes in various healthcare applications. It can be argued that the reason, most particularly, is the limitations and uncertainties associated with the current instrumentation and simulation capabilities which has led to several streams of test protocols. This review highlights the current understanding on the mechano-bactericidal mechanisms in light of the contributing factors and various techniques which are used to postulate these mechanisms. The review offers a critique on the variations observed on how nanostructured surfaces found in literature have been evaluated such that the test protocols and the outcomes are incomparable. The review also shows a strong need of developing more accurate models of a bacterium as the currently reported experimental data is insufficient to develop bacteria’s material models (constitutive equations). The review also alludes to the scarcity of direct experimental evidence of the mechano-bactericidal mechanism suggesting a strong need for further in-situ monitoring as a future research direction. |
Keywords | General Materials Science |
Year | 2022 |
Journal | ACS Applied Nano Materials |
Journal citation | 5 (1), pp. 1-17 |
Publisher | American Chemical Society (ACS) |
ISSN | 2574-0970 |
Digital Object Identifier (DOI) | https://doi.org/10.1021/acsanm.1c03045 |
Web address (URL) | https://pubs.acs.org/journal/aanmf6 |
Funder/Client | Engineering and Physical Sciences Research Council |
Publication dates | |
Online | 05 Jan 2022 |
28 Jan 2022 | |
Publication process dates | |
Accepted | 20 Dec 2021 |
Deposited | 05 Jan 2022 |
Accepted author manuscript | File Access Level Open |
Additional information | This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in ACS Applied Nano Material, copyright © American Chemical Society after peer review. To access the final edited and published work see https://pubs.acs.org/journal/aanmf6 |
License | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
https://openresearch.lsbu.ac.uk/item/8yyx9
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