Effect of exercise-induced enhancement of the leg-extensor muscle-tendon unit capacities on ambulatory mechanics and knee osteoarthritis markers in the elderly.

Journal article


Karamanidis, K, Oberländer, KD, Niehoff, A, Epro, G and Brüggemann, G-P (2014). Effect of exercise-induced enhancement of the leg-extensor muscle-tendon unit capacities on ambulatory mechanics and knee osteoarthritis markers in the elderly. PLoS ONE. 9 (6).
AuthorsKaramanidis, K, Oberländer, KD, Niehoff, A, Epro, G and Brüggemann, G-P
Abstract

OBJECTIVE: Leg-extensor muscle weakness could be a key component in knee joint degeneration in the elderly because it may result in altered muscular control during locomotion influencing the mechanical environment within the joint. This work aimed to examine whether an exercise-induced enhancement of the triceps surae (TS) and quadriceps femoris (QF) muscle-tendon unit (MTU) capacities would affect mechanical and biological markers for knee osteoarthritis in the elderly. METHODS: Twelve older women completed a 14-week TS and QF MTU exercise intervention, which had already been established as increasing muscle strength and tendon stiffness. Locomotion mechanics and serum cartilage oligomeric matrix protein (COMP) levels were examined during incline walking. MTU mechanical properties were assessed using simultaneously ultrasonography and dynamometry. RESULTS: Post exercise intervention, the elderly had higher TS and QF contractile strength and tendon-aponeurosis stiffness. Regarding the incline gait task, the subjects demonstrated a lower external knee adduction moment and lower knee adduction angular impulse during the stance phase post-intervention. Furthermore, post-intervention compared to pre-intervention, the elderly showed lower external hip adduction moment, but revealed higher plantarflexion pushoff moment. The changes in the external knee adduction moment were significantly correlated with the improvement in ankle pushoff function. Serum COMP concentration increased in response to the 0.5-h incline walking exercise with no differences in the magnitude of increment between pre- and post-intervention. CONCLUSIONS: This work emphasizes the important role played by the ankle pushoff function in knee joint mechanical loading during locomotion, and may justify the inclusion of the TS MTU in prevention programs aiming to positively influence specific mechanical markers for knee osteoarthritis in the elderly. However, the study was unable to show that COMP is amenable to change in the elderly following a 14-week exercise intervention and, therefore, the physiological benefit of improved muscle function for knee cartilage requires further investigation.

KeywordsMuscle, Skeletal; Tendons; Humans; Osteoarthritis, Knee; Gait; Exercise Therapy; Locomotion; Aged; Female; Biomechanical Phenomena; Aged; Biomechanical Phenomena; Exercise Therapy; Female; Gait; Humans; Locomotion; Muscle, Skeletal; Osteoarthritis, Knee; Tendons; Ultrasonography; MD Multidisciplinary; General Science & Technology
Year2014
JournalPLoS ONE
Journal citation9 (6)
PublisherPublic Library of Science
ISSN1932-6203
Digital Object Identifier (DOI)doi:10.1371/journal.pone.0099330
Publication dates
Print06 Jun 2014
Publication process dates
Deposited31 Jul 2017
Accepted06 Jun 2014
Accepted author manuscript
License
CC BY 4.0
Permalink -

https://openresearch.lsbu.ac.uk/item/8781q

  • 1
    total views
  • 31
    total downloads
  • 1
    views this month
  • 2
    downloads this month

Related outputs

Evidence of a Uniform Muscle-Tendon Unit Adaptation in Healthy Elite Track and Field Jumpers: A Cross Sectional Investigation.
Epro, G, Hunter, S, König, M, Schade, F and Karamanidis, K (2019). Evidence of a Uniform Muscle-Tendon Unit Adaptation in Healthy Elite Track and Field Jumpers: A Cross Sectional Investigation. Frontiers in physiology. 10, p. 574.
Stability-normalised walking speed: A new approach for human gait perturbation research
McCrum, C, Willems, P, Karamanidis, K and Meijer, K (2019). Stability-normalised walking speed: A new approach for human gait perturbation research. Journal of Biomechanics.
Retention, savings and interlimb transfer of reactive gait adaptations in humans following unexpected perturbations
McCrum, C, Karamanidis, K, Willems, P, Zijlstra, W and Meijer, K (2018). Retention, savings and interlimb transfer of reactive gait adaptations in humans following unexpected perturbations. Communications biology. 1 (1), p. 230.
Retention of improvement in gait stability over 14 weeks due to trip-perturbation training is dependent on perturbation dose
König, M, Epro, G, Seeley, J, Catalá-Lehnen, P, Potthast, W and Karamanidis, K (2018). Retention of improvement in gait stability over 14 weeks due to trip-perturbation training is dependent on perturbation dose. Journal of Biomechanics. 84, pp. 243-246.
Matching Participants for Triceps Surae Muscle Strength and Tendon Stiffness Does Not Eliminate Age-Related Differences in Mechanical Power Output During Jumping
Koenig, M, Hemmers, S, Epro, G, McCrum, C, Ackermans, TMA, Hartmann, U and Karamanidis, K (2018). Matching Participants for Triceps Surae Muscle Strength and Tendon Stiffness Does Not Eliminate Age-Related Differences in Mechanical Power Output During Jumping. Frontiers in physiology. 9, p. 1345.
Positive Work Contribution Shifts from Distal to Proximal Joints during a Prolonged Run
Sanno, M, Willwacher, S, Epro, G and Brüggemann, G-P (2018). Positive Work Contribution Shifts from Distal to Proximal Joints during a Prolonged Run. Medicine and Science in Sports and Exercise.
The role of muscle strength on tendon adaptability in old age
Holzer, D, Epro, G, McCrum, C, Doerner, J, Luetkens, JA, Scheef, L, Kukuk, GM, Boecker, H, Mierau, A, Brüggemann, G-P, Maganaris, CN and Karamanidis, K (2018). The role of muscle strength on tendon adaptability in old age. European Journal of Applied Physiology.
Effects of Corrective Training on Drop Landing Ground Reaction Force Characteristics and Lower Limb Kinematics in Older Adults With Genu Valgus: A Randomized Controlled Trial.
Jafarnezhadgero, A, Madadi-Shad, M, McCrum, C and Karamanidis, K (2018). Effects of Corrective Training on Drop Landing Ground Reaction Force Characteristics and Lower Limb Kinematics in Older Adults With Genu Valgus: A Randomized Controlled Trial. Journal of Aging and Physical Activity.
Retention of gait stability improvements over 1.5 years in older adults: effects of perturbation exposure and triceps surae neuromuscular exercise.
Epro, G, Mierau, A, McCrum, C, Leyendecker, M, Brüggemann, G-P and Karamanidis, K (2018). Retention of gait stability improvements over 1.5 years in older adults: effects of perturbation exposure and triceps surae neuromuscular exercise. Journal of Neurophysiology.
Alterations in Leg Extensor Muscle-Tendon Unit Biomechanical Properties With Ageing and Mechanical Loading.
McCrum, C, Leow, P, Epro, G, König, M, Meijer, K and Karamanidis, K (2018). Alterations in Leg Extensor Muscle-Tendon Unit Biomechanical Properties With Ageing and Mechanical Loading. Frontiers in physiology. 9, p. 150.
Effects of triceps surae muscle strength and tendon stiffness on the reactive dynamic stability and adaptability of older female adults during perturbed walking.
Epro, G, McCrum, C, Mierau, A, Leyendecker, M, Brüggemann, G-P and Karamanidis, K (2018). Effects of triceps surae muscle strength and tendon stiffness on the reactive dynamic stability and adaptability of older female adults during perturbed walking. Journal of Applied Physiology.
Loading rate and contraction type effects on the human Achilles tendon force-elongation relationship
McCrum, C, Oberländer, KD, Epro, G, Krauss, P, Reeves, N and Karamanidis, K (2017). Loading rate and contraction type effects on the human Achilles tendon force-elongation relationship. 22nd Annual Congress of the European College of Sport Science. Essen, Germany 05 - 08 Jul 2017 London South Bank University.
Loading rate and contraction duration effects on in vivo human Achilles tendon mechanical properties.
McCrum, C, Oberländer, KD, Epro, G, Krauss, P, James, DC, Reeves, N and Karamanidis, K (2017). Loading rate and contraction duration effects on in vivo human Achilles tendon mechanical properties. Clinical Physiology and Functional Imaging.
Muscle-tendon adaptation monitoring in elite athletes: Preliminary results from a longitudinal investigation
Epro, G, Koenig, M, McCrum, C, Baedorf, M, Schade, F and Karamanidis, K (2017). Muscle-tendon adaptation monitoring in elite athletes: Preliminary results from a longitudinal investigation. 35th Conference of the International Society of Biomechanics in Sport. Cologne, Germany 14 - 18 Jun 2017 London South Bank University.
Achilles tendon mechanosensitivity is preserved in old age: In vivo evidence from a 1.5 years long resistance training intervention
Epro, G, Mierau, A, Doerner, J, Luetkens, J, Scheef, L, Kukuk, G, Boecker, H, Maganaris, C, Brüggemann, G-P and Karamanidis, K (2017). Achilles tendon mechanosensitivity is preserved in old age: In vivo evidence from a 1.5 years long resistance training intervention. 22nd annual Congress of the European College of Sport Science. Essen, Germany 05 - 08 Jul 2017 London South Bank University.
Matching participants for triceps surae mechanical properties eliminates age-related differences in drop jump performance
Koenig, M, Hemmers, S, McCrum, C, Epro, G, Ackermans, TMA, Hartmann, U and Karamanidis, K (2016). Matching participants for triceps surae mechanical properties eliminates age-related differences in drop jump performance. 11th Joint Conference on Motor Control & Learning, Biomechanics & Training of the German Society of Sports Sciences. Darmstadt, Germany 28 - 30 Sep 2016 London South Bank University.
Deficient recovery response and adaptive feedback potential in dynamic gait stability in unilateral peripheral vestibular disorder patients.
McCrum, C, Eysel-Gosepath, K, Epro, G, Meijer, K, Savelberg, HHCM, Brüggemann, G-P and Karamanidis, K (2014). Deficient recovery response and adaptive feedback potential in dynamic gait stability in unilateral peripheral vestibular disorder patients. Physiological Reports. 2 (12), pp. 1-10.
Locomotor stability and adaptation during perturbed walking across the adult female lifespan.
McCrum, C, Epro, G, Meijer, K, Zijlstra, W, Brüggemann, G-P and Karamanidis, K (2016). Locomotor stability and adaptation during perturbed walking across the adult female lifespan. Journal of Biomechanics. 49 (7), pp. 1244-1247.
Visual and proprioceptive contributions to postural control of upright stance in unilateral vestibulopathy.
Eysel-Gosepath, K, McCrum, C, Epro, G, Brüggemann, G-P and Karamanidis, K (2016). Visual and proprioceptive contributions to postural control of upright stance in unilateral vestibulopathy. Somatosensory and Motor Research. 33 (2), pp. 72-78.
Aging and the effects of a half marathon on Achilles tendon force-elongation relationship.
Ackermans, TMA, Epro, G, McCrum, C, Oberländer, KD, Suhr, F, Drost, MR, Meijer, K and Karamanidis, K (2016). Aging and the effects of a half marathon on Achilles tendon force-elongation relationship. European Journal of Applied Physiology. 116 (11-12), pp. 2281-2292.
Use of a Lucas-Kanade-Based Template Tracking Algorithm to Examine In Vivo Tendon Excursion during Voluntary Contraction Using Ultrasonography.
Karamanidis, K, Travlou, A, Krauss, P and Jaekel, U (2016). Use of a Lucas-Kanade-Based Template Tracking Algorithm to Examine In Vivo Tendon Excursion during Voluntary Contraction Using Ultrasonography. Ultrasound in Medicine and Biology. 42 (7), pp. 1689-1700.
Effect of long-term exercise-induced changes of the triceps surae muscle-tendon unit properties on maximal walking velocity in the elderly
Epro, G, Mierau, A, Brüggemann, G-P and Karamanidis, K (2017). Effect of long-term exercise-induced changes of the triceps surae muscle-tendon unit properties on maximal walking velocity in the elderly. 10. Jahrestagung der Deutschen Gesellschaft für Biomechanik (DGfB). Hannover, Germany 29 - 31 Mar 2017 London South Bank University.
Muscle and tendon adaptation in young and older adult athletes: A combined longitudinal and cross sectional investigation
Koenig, M, Epro, G, McCrum, C, Ackermans, TMA, Schade, F and Karamanidis, K (2017). Muscle and tendon adaptation in young and older adult athletes: A combined longitudinal and cross sectional investigation. 10. Jahrestagung der Deutschen Gesellschaft für Biomechanik. Hannover 29 - 31 Mar 2017 London South Bank University.
Simplified triceps surae muscle volume assessment in the elderly
Epro, G, Koenig, M, Mersmann, F, Arampatzis, A and Karamanidis, K (2017). Simplified triceps surae muscle volume assessment in the elderly. 10. Jahrestagung der Deutschen Gesellschaft für Biomechanik (DGfB). Hannover, Germany 29 - 31 Mar 2017 London South Bank University.
The Achilles tendon is mechanosensitive in older adults: adaptations following 14 weeks versus 1.5 years of cyclic strain exercise.
Epro, G, Mierau, A, Doerner, J, Luetkens, J, Scheef, L, Kukuk, G, Boecker, H, Maganaris, C, Brüggemann, G-P and Karamanidis, K (2017). The Achilles tendon is mechanosensitive in older adults: adaptations following 14 weeks versus 1.5 years of cyclic strain exercise. Journal of Experimental Biology. 220 (Pt 6), pp. 1008-1018.
A systematic review of gait perturbation paradigms for improving reactive stepping responses and falls risk among healthy older adults.
McCrum, C, Gerards, MHG, Karamanidis, K, Zijlstra, W and Meijer, K (2017). A systematic review of gait perturbation paradigms for improving reactive stepping responses and falls risk among healthy older adults. European Review of Aging and Physical Activity. 14, p. 3.
Age-related differences in drop-jump performance are eliminated by matching triceps surae muscle strength and Achilles tendon stiffness.
Koenig, M, Hemmers, S, McCrum, C, Epro, G, Ackermans, TMA, Hartmann, U and Karamanidis, K (2017). Age-related differences in drop-jump performance are eliminated by matching triceps surae muscle strength and Achilles tendon stiffness. 2017 BASES Biomechanics Interest Group (BIG) Meeting, Portsmouth. Portsmouth 19 - 19 Apr 2017 London South Bank University.
The effect of habitual athletics training on muscle and tendon adaptation in young and older elite athletes.
Koenig, M, Epro, G, McCrum, C, Bädorf, M, Schade, F and Karamanidis, K (2017). The effect of habitual athletics training on muscle and tendon adaptation in young and older elite athletes. 2017 BASES Biomechanics Interest Group (BIG) Meeting, Portsmouth. Portsmouth 19 - 19 Apr 2017 London South Bank University.
Age-related differences in drop jump performance are eliminated when triceps surae mechanical properties are matched
Koenig, M, Hemmers, S, McCrum, C, Epro, G, Ackermans, TMA, Hartmann, U and Karamanidis, K (2016). Age-related differences in drop jump performance are eliminated when triceps surae mechanical properties are matched. Dutch Society for Movement Sciences (VvBN) PhD Day 2016. Maastricht 09 - 09 Nov 2016 London South Bank University.
Associations Between Bipedal Stance Stability and Locomotor Stability Following a Trip in Unilateral Vestibulopathy
McCrum, C, Eysel-Gosepath, K, Epro, G, Meijer, K, Savelberg, HHCM, Brüggemann, G-P and Karamanidis, K (2017). Associations Between Bipedal Stance Stability and Locomotor Stability Following a Trip in Unilateral Vestibulopathy. Journal of applied biomechanics. 33 (2), pp. 112-117.
EFFECT OF TRICEPS SURAE MUSCLE-TENDON UNIT MECHANICAL PROPERTIES ON GAIT STABILITY AND ADAPTABILITY IN OLDER FEMALE ADULTS
Epro, G, McCrum, C, Mierau, A, Leyendecker, M, Brüggemann, G-P and Karamanidis, K (2017). EFFECT OF TRICEPS SURAE MUSCLE-TENDON UNIT MECHANICAL PROPERTIES ON GAIT STABILITY AND ADAPTABILITY IN OLDER FEMALE ADULTS. BASES Biomechanics Interest Group (BIG) Meeting 2017. Portsmouth, UK 19 - 19 Apr 2017 London South Bank University.
Achilles tendon is mechanosensitive in old adults: a 1.5 year resistance training intervention
Epro, G, Mierau, A, Doerner, J, Luetkens, J, Scheef, L, Kukuk, G, Boecker, H, Maganaris, C and Karamanidis, K (2017). Achilles tendon is mechanosensitive in old adults: a 1.5 year resistance training intervention. BASES Biomechanics Interest Group (BIG) Meeting 2017. Portsmouth, UK 19 - 19 May 2017 London South Bank University.
Matching triceps surae muscle strength and tendon stiffness eliminates age-related differences in drop-jump performance
Koenig, M, Hemmers, S, McCrum, C, Epro, G, Ackermans, TMA, Hartmann, U and Karamanidis, K (2017). Matching triceps surae muscle strength and tendon stiffness eliminates age-related differences in drop-jump performance. 35th International Conference on Biomechanics in Sports. Cologne 14 - 18 Jun 2017 London South Bank University.
Monitoring muscle-tendon adaptation in elite athletes: Preliminary data from a 1-year longitudinal investigation
Koenig, M, Epro, G, McCrum, C, Bädorf, M, Schade, F and Karamanidis, K (2017). Monitoring muscle-tendon adaptation in elite athletes: Preliminary data from a 1-year longitudinal investigation. 22nd annual Congress of the European College of Sport Science (ECSS). Essen 05 - 08 Jul 2017 London South Bank University.