Mr-Nom: Multi-Scale Resolution of Neuronal Cells in Nissl-Stained Histological Slices Via Deliberate over-Segmentation and Merging
Journal article
Vadori, V., Graïc, J-M., Finos, L., Corain, L., Peruffo, A. and Grisan, E. (2023). Mr-Nom: Multi-Scale Resolution of Neuronal Cells in Nissl-Stained Histological Slices Via Deliberate over-Segmentation and Merging. 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI). https://doi.org/10.1109/isbi53787.2023.10230352
| Authors | Vadori, V., Graïc, J-M., Finos, L., Corain, L., Peruffo, A. and Grisan, E. |
|---|---|
| Abstract | In comparative neuroanatomy, the characterization of brain cytoarchitecture is critical to a better understanding of brain structure and function, as it helps to distill information on the development, evolution, and distinctive features of different populations. The automatic segmentation of individual brain cells is a primary prerequisite and yet remains challenging. A new method (MR-NOM) was developed for the instance segmentation of cells in Nissl-stained histological images of the brain. MR-NOM exploits a multi-scale approach to deliberately over-segment the cells into superpixels and subsequently merge them via a classifier based on shape, structure, and intensity features. The method was tested on images of the cerebral cortex, proving successful in dealing with cells of varying characteristics that partially touch or overlap, showing better performance than two state-of-the-art methods. |
| Year | 2023 |
| Journal | 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI) |
| Publisher | IEEE |
| ISSN | 1945-8452 |
| Digital Object Identifier (DOI) | https://doi.org/10.1109/isbi53787.2023.10230352 |
| Publication dates | |
| 18 Apr 2023 | |
| Publication process dates | |
| Deposited | 16 Nov 2023 |
| Accepted author manuscript | License File Access Level Open |
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