Multi-aspect testing and ranking inference to quantify dimorphism in the cytoarchitecture of cerebellum of male, female and intersex individuals: a model applied to bovine brains.
Journal article
Corain, L., Grisan, E., Graïc, J., Carvajal-Schiaffino, R., Cozzi, B. and Peruffo, A. (2020). Multi-aspect testing and ranking inference to quantify dimorphism in the cytoarchitecture of cerebellum of male, female and intersex individuals: a model applied to bovine brains. Brain structure & function. https://doi.org/10.1007/s00429-020-02147-x
| Authors | Corain, L., Grisan, E., Graïc, J., Carvajal-Schiaffino, R., Cozzi, B. and Peruffo, A. |
|---|---|
| Abstract | The dimorphism among male, female and freemartin intersex bovines, focusing on the vermal lobules VIII and IX, was analyzed using a novel data analytics approach to quantify morphometric differences in the cytoarchitecture of digitalized sections of the cerebellum. This methodology consists of multivariate and multi-aspect testing for cytoarchitecture-ranking, based on neuronal cell complexity among populations defined by factors, such as sex, age or pathology. In this context, we computed a set of shape descriptors of the neural cell morphology, categorized them into three domains named size, regularity and density, respectively. The output and results of our methodology are multivariate in nature, allowing an in-depth analysis of the cytoarchitectonic organization and morphology of cells. Interestingly, the Purkinje neurons and the underlying granule cells revealed the same morphological pattern: female possessed larger, denser and more irregular neurons than males. In the Freemartin, Purkinje neurons showed an intermediate setting between males and females, while the granule cells were the largest, most regular and dense. This methodology could be a powerful instrument to carry out morphometric analysis providing robust bases for objective tissue screening, especially in the field of neurodegenerative pathologies. |
| Keywords | Brain dimorphism; Cerebellum; Cytoarchitecture morphometrics; Image analysis; Multi-aspect analysis in neuroanatomy |
| Year | 2020 |
| Journal | Brain structure & function |
| Publisher | Springer |
| ISSN | 1863-2661 |
| Digital Object Identifier (DOI) | https://doi.org/10.1007/s00429-020-02147-x |
| Funder/Client | Università degli Studi di Padova |
| Publication dates | |
| Online | 28 Sep 2020 |
| Publication process dates | |
| Deposited | 10 Sep 2020 |
| Accepted | 08 Sep 2020 |
| Publisher's version | License File Access Level Open |
| Accepted author manuscript | License File Access Level Controlled |
Permalink -
https://openresearch.lsbu.ac.uk/item/8q8q9
Download files
Publisher's version
| Corain2020_Article_Multi-aspectTestingAndRankingI.pdf | ||
| License: CC BY 4.0 | ||
| File access level: Open | ||
60
total views28
total downloads3
views this month0
downloads this month
Export as
Related outputs
A Virtual Chromoendoscopy Artificial Intelligence System To Detect Endoscopic And Histologic Remission In Ulcerative Colitis
Iacucci M., Cannatelli, R., Parigi, T.L., Buda, A., Labarile, N., Nardone, O. M., Tontini, G. E., Rimondi, A., Bazarova, A., Bhandari, P., Bisschops, R., De Hertogh, G., Del Amor, R., Ferraz, J. G., Goetz, M., Gui, S. X., Hayee, B., Kiesslich, R., Lazarev, M., Naranjo, V., Panaccione, R., Parra-Blanco, A., Pastorelli, L., Rath, T., Røyset, E. S., Vieth, M., Villanacci, V., Zardo, D., Ghosh, S. and Grisan, E. (2022). A Virtual Chromoendoscopy Artificial Intelligence System To Detect Endoscopic And Histologic Remission In Ulcerative Colitis. Digestive Disease Week - DDW 2022. San Diego (CA) 21 - 24 May 2022A Deep Graph Cut Model for 3D Brain Tumor Segmentation
De, A., Tiwari, M., Grisan, E. and Chowdhury, A.S. (2022). A Deep Graph Cut Model for 3D Brain Tumor Segmentation. 44th International Engineering in Medicine and Biology Conference (EMBC 2022). Glasgow (UK) 11 - 15 Jul 2022 IEEE.OP16 The first virtual chromoendoscopy artificial intelligence system to detect endoscopic and histologic remission in Ulcerative Colitis
Iacucci, M, Cannatelli, R, Parigi, TL, Buda, A, Labarile, N, Nardone, OM, Tontini, GE, Rimondi, A, Bazarova, A, Bhandari, P, Bisschops, R, De Hertogh, G, Del Amor, R, Ferraz, JG, Goetz, M, Gui, X, Hayee, B, Kiesslich, R, Lazarev, M, Naranjo, V, Panaccione, R, Parra-Blanco, A, Pastorelli, L, Rath, T, Røyset, ES, Vieth, M, Villanacci, V, Zardo, D, Ghosh, S and Grisan, E. (2022). OP16 The first virtual chromoendoscopy artificial intelligence system to detect endoscopic and histologic remission in Ulcerative Colitis. Journal of Crohn's and Colitis. 16 (Suppl 1), p. i017–i018. https://doi.org/10.1093/ecco-jcc/jjab232.015OP15 A new simplified histology artificial intelligence system for accurate assessment of remission in Ulcerative Colitis
Villanacci, V, Parigi, TL, Del Amor, R, Mesguer Esbrì, P, Gui, X, Bazarova, A, Bhandari, P, Bisschops, R, Danese, S, De Hertogh, G, G Ferraz, JG, Götz, M, Grisan, E., Hayee, B, Kiesslich, R, Lazarev, M, Mandelli, G, Monica, MAT, Panaccione, R, Parra-Blanco, A, Pastorelli, L, Rath, T, Røyset, ES, Shivaji, U, Tontini, GE, Vieth, M, Zardo, D, Ghosh, S, Naranjo, V and Iacucci, M (2022). OP15 A new simplified histology artificial intelligence system for accurate assessment of remission in Ulcerative Colitis. Journal of Crohn's and Colitis. 16 (Suppl 1), p. i015–i017. https://doi.org/10.1093/ecco-jcc/jjab232.014Predicting functional impairment trajectories in amyotrophic lateral sclerosis: a probabilistic, multifactorial model of disease progression.
Tavazzi, E., Daberdaku, S., Zandonà, A., Vasta, R., Nefussy, B., Lunetta, C., Mora, G., Mandrioli, J., Grisan, E., Tarlarini, C., Calvo, A., Moglia, C., Drory, V., Gotkine, M., Chiò, A., Di Camillo, B. and Piemonte, Valle d’Aosta Register for ALS (PARALS), for the Emilia Romagna Registry for ALS (ERRALS) (2022). Predicting functional impairment trajectories in amyotrophic lateral sclerosis: a probabilistic, multifactorial model of disease progression. Journal of neurology. https://doi.org/10.1007/s00415-022-11022-0An Adaptive Registration Algorithm for Zebrafish Larval Brain Images
Deb, S, Tiso, N, Grisan, E. and Chowdhury, A.S. (2022). An Adaptive Registration Algorithm for Zebrafish Larval Brain Images. Computer methods and programs in biomedicine. 216, p. 106658. https://doi.org/10.1016/j.cmpb.2022.106658PICaSSO Histologic Remission Index (PHRI) in Ulcerative Colitis – Development of a Novel Simplified Histological Score for Monitoring Mucosal Healing and Predicting Clinical Outcomes and its Applicability in an Artificial Intelligence System
Gui, X., Bazarova, A., del Amor, R., Vieth, M., de Hertogh, G., Villanacci, V., Zardo, D., Parigi, T. L., Røyset, E., Shivaji, U., Monica, M. A.T., Mandelli, G., Bhandari, P., Danese, S., Ferraz, J., Hayee, B., Lazarev, M., Parra-Blanco, A., Pastorelli, L., Panaccione, R., Rath, T., Tontini, G.E., Ralf, H., Bisschops, R., Grisan, E., Naranjo, V., Ghosh, S. and Iacucci, M. (2022). PICaSSO Histologic Remission Index (PHRI) in Ulcerative Colitis – Development of a Novel Simplified Histological Score for Monitoring Mucosal Healing and Predicting Clinical Outcomes and its Applicability in an Artificial Intelligence System. Gut. https://doi.org/10.1136/gutjnl-2021-326376The primary visual cortex of Cetartiodactyls: organization, cytoarchitectonics and comparison with perissodactyls and primates.
Graïc, J., Peruffo, A., Corain, L., Finos, L., Grisan, E. and Cozzi, B. (2021). The primary visual cortex of Cetartiodactyls: organization, cytoarchitectonics and comparison with perissodactyls and primates. Brain structure & function. https://doi.org/10.1007/s00429-021-02392-8Deep learning for the prediction of treatment response in depression
Squarcina, L., Villa, F.M., Nobile, M., Grisan, E. and Brambilla, P. (2021). Deep learning for the prediction of treatment response in depression. Journal of Affective Disorders. 281, pp. 618-622. https://doi.org/10.1016/j.jad.2020.11.104Response to Biologics in Ibd Patients Assessed by Computerized Image Analysis of Probe Based Confocal Laser Endomicroscopy With Molecular Labeling
Iacucci, M, Grisan, E, Labarile, N, Nardone, OM, Smith, SCL, Jeffery, L, Cannatelli, R, Ghosh, S and Buda, A (2021). Response to Biologics in Ibd Patients Assessed by Computerized Image Analysis of Probe Based Confocal Laser Endomicroscopy With Molecular Labeling. ESGE Days 2021. Virtual 25 - 27 Mar 2021 Georg Thieme Verlag KG. https://doi.org/10.1055/s-0041-1724759Deep-Learning Estimation of Perfusion Kinetic Parameters in Contrast-Enhanced Ultrasound Imaging
Grisan, E., Harput, S., Raffeiner, B., Fiocco, U. and Stramare, R. (2021). Deep-Learning Estimation of Perfusion Kinetic Parameters in Contrast-Enhanced Ultrasound Imaging. IEEE International Symposium on Biomedical Imaging - IEEE ISBI. Nice 13 - 16 Apr 2021 Institute of Electrical and Electronics Engineers (IEEE).The claustrum of the sheep and its connections to the visual cortex
Pirone, A., Graïc, J., Grisan, E. and Cozzi, B. (2020). The claustrum of the sheep and its connections to the visual cortex. Journal of Anatomy. 238 (1), pp. 1-12. https://doi.org/10.1111/joa.13302Is machine learning prediction of Aβ positivity consistent? An assessment of multiple datasets
Grecchi, E., Grisan, E., Buckley, C. and Wolber, J. (2020). Is machine learning prediction of Aβ positivity consistent? An assessment of multiple datasets. Wiley. https://doi.org/10.1002/alz.040990Single- and Multi-Distribution Dimensionality Reduction Approaches for a Better Data Structure Capturing
Hajderanj, L., Chen, D., Grisan, E. and Dudley-McEvoy, S (2020). Single- and Multi-Distribution Dimensionality Reduction Approaches for a Better Data Structure Capturing. IEEE Access. 8, pp. 207141 - 207155. https://doi.org/10.1109/ACCESS.2020.3038460Preface to: EndoCV2020Computer Vision in Endoscopy
Ali, S, Daul, C, Rittscher, J, Stoyanov, D and Grisan, E (2020). Preface to: EndoCV2020Computer Vision in Endoscopy. CEUR Workshop Proceedings. 2595.An assay system to evaluate riboflavin/UV-A corneal phototherapy efficacy in a porcine corneal organ culture model
Perazzi, A, Gomiero, C, Corain, Livio, Iacopetti, Ilaria, Grisan, Enrico, Lombardo, Marco, Lombardo, Giuseppe, Salvalaio, Gianni, Contin, Roberta, Patruno, Marco, Martinello, Tiziana and Peruffo, Antonella (2020). An assay system to evaluate riboflavin/UV-A corneal phototherapy efficacy in a porcine corneal organ culture model. Animals. 10, pp. 1-16. https://doi.org/10.3390/ani10040730An objective comparison of detection and segmentation algorithms for artefacts in clinical endoscopy
Ali, S., Zhou, F., Braden, B., Bailey, A., Yang, S., Cheng, G., Zhang, P., Li, X., Kayser, M., Soberanis-Mukul, R., Albarqouni, S., Wang, X., Wang, C., Watanabe, S., Oksuz, I., Ning, Q., Yang, S., Khan, M.A., Gao, X., Realdon, S., Loshchenov, M., Schnabel, J., East, J., Wagnieres, G., Loschenov, V., Grisan, E., Daul, C., Blondel, W. and Rittscher, J. (2020). An objective comparison of detection and segmentation algorithms for artefacts in clinical endoscopy. Scientific Reports. 10, p. 2748. https://doi.org/10.1038/s41598-020-59413-5In-vivo Barretts esophagus digital pathology stage classification through feature enhancement of confocal laser endomicroscopy
Ghatwary, N, Ahmed, A, Grisan, E, Jalab, H, Bidaut, L and Ye, X (2019). In-vivo Barretts esophagus digital pathology stage classification through feature enhancement of confocal laser endomicroscopy. J Med Imaging (Bellingham). 6 (1). https://doi.org/https://www.doi.org/10.1117/1.JMI.6.1.014502Real-time diameter of the fetal aorta from ultrasound
Savioli, Nicolò, Grisan, Enrico, Visentin, Silvia, Cosmi, Erich, Montana, Giovanni and Lamata, Pablo (2019). Real-time diameter of the fetal aorta from ultrasound. Neural Computing and Applications. https://doi.org/10.1007/s00521-019-04646-3Does Quantification of Carotid Plaque Surface Irregularities Better Detect Symptomatic Plaques Compared to the Subjective Classification?
Rafailidis, V., Chryssogonidis, I., Grisan, E., Xerras, C., Cheimariotis, G-A., Tegos, T., Rafailidis, D., Sidhu, P. and Charitanti-Kouridou, A. (2019). Does Quantification of Carotid Plaque Surface Irregularities Better Detect Symptomatic Plaques Compared to the Subjective Classification? Journal of Ultrasound in Medicine. 38 (12), pp. 3163-3171. https://doi.org/10.1002/jum.15017An ultrasonographic multiparametric carotid plaque risk index associated with cerebrovascular symptomatology: A study comparing color Doppler imaging and contrast-enhanced ultrasonography
Rafailidis, V., Chryssogonidis, I., Xerras, C., Grisan, E., Cheimariotis, G-A., Tegos, T., Rafailidis, P.S., Sidhu, P.S. and Charitanti-Kouridou, A. (2019). An ultrasonographic multiparametric carotid plaque risk index associated with cerebrovascular symptomatology: A study comparing color Doppler imaging and contrast-enhanced ultrasonography. American Journal of Neuroradiology. 40 (6), pp. 1022-1028. https://doi.org/10.3174/ajnr.A6056The motor cortex of the sheep: laminar organization, projections and diffusion tensor imaging of the intracranial pyramidal and extrapyramidal tracts
Peruffo, A., Corain, L., Bombardi, C., Centelleghe, C., Grisan, E., Graïc, J-M, Bontempi, P., Grandis, A. and Cozzi, B. (2019). The motor cortex of the sheep: laminar organization, projections and diffusion tensor imaging of the intracranial pyramidal and extrapyramidal tracts. Brain Structure and Function. 224 (5), pp. 1933-1946. https://doi.org/10.1007/s00429-019-01885-xBuilding a reduced dictionary of relevant perfusion patterns from CEUS data for the classification of testis lesions
Favaron, T., Huang, D.Y., Christensen-Jeffries, K., Eckersley, R., Sidhu, P.S. and Grisan, E. (2019). Building a reduced dictionary of relevant perfusion patterns from CEUS data for the classification of testis lesions. 2019 IEEE 16th International Symposium on Biomedical Imaging. Venice, Italy 08 - 11 Apr 2019 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ISBI.2019.8759528Deep Convolutional Neural Network for Survival Estimation of Amyotrophic Lateral Sclerosis patients
Grisan, E., Zandon`a, A. and Di Camillo, B. (2019). Deep Convolutional Neural Network for Survival Estimation of Amyotrophic Lateral Sclerosis patients. European Symposium on Artificial Neural Networks, Computational Intelligence and Machine Learning. Bruges, Belgium 24 - 26 Apr 2019 i6doc.Prediction of Adverse Glycemic Events from Continuous Glucose Monitoring Signal
Gadaleta, M., Facchinetti, A., Grisan, E. and Rossi, M. (2019). Prediction of Adverse Glycemic Events from Continuous Glucose Monitoring Signal. IEEE Journal of Biomedical and Health Informatics. 23 (2). https://doi.org/10.1109/JBHI.2018.2823763Sparse Image Reconstruction for Contrast Enhanced Cardiac Ultrasound using Diverging Waves
Stanziola, A., Toulemonde, M., Papadopoulou, V., Corbett, R., Duncan, N., Grisan, E. and Tang, M-X. (2019). Sparse Image Reconstruction for Contrast Enhanced Cardiac Ultrasound using Diverging Waves. IEEE International Ultrasonics Symposium 2019. Glasgow 09 2009 - 06 Oct 2019 Institute of Electrical and Electronics Engineers (IEEE).Super resolution ultrasound image filtering with machine learning to reduce the localization error
Harput, S., Fong, L.H., Stanziola, A., Zhang, G., Toulemonde, M., Zhou, J., Christensen-Jeffries, K., Brown, J., Eckersley, R., Grisan, E., Dunsby, C. and Tang, M. (2019). Super resolution ultrasound image filtering with machine learning to reduce the localization error. IEEE International Ultrasonics Symposium 2019. Glasgow 09 2009 - 06 Oct 2019 Institute of Electrical and Electronics Engineers (IEEE).Temporal Convolution Networks for Real-Time Abdominal Fetal Aorta Analysis with Ultrasound
Savioli, N., Visentin, S., Cosmi, E., Grisan, E., Lamata, P. and Montana, G. (2018). Temporal Convolution Networks for Real-Time Abdominal Fetal Aorta Analysis with Ultrasound. Artificial Neural Networks and Machine Learning – ICANN 2018. Rhodes, Greece 04 - 07 Oct 2018 Springer. https://doi.org/10.1007/978-3-030-01421-6_15Quantitative imaging by pixel-based contrast-enhanced ultrasound reveals a linear relationship between synovial vascular perfusion and the recruitment of pathogenic IL-17A-F+IL-23+ CD161+ CD4+ T helper cells in psoriatic arthritis joints
Fiocco, U, Stramare, R, Martini, V, Coran, A, Caso, F, Costa, L, Felicetti, M, Rizzo, G, Tonietto, M, Scanu, A, Oliviero, F, Raffeiner, B, Vezzù, M, Lunardi, F, Scarpa, R, Sacerdoti, D, Rubaltelli, L, Punzi, L, Doria, A and Grisan, E (2017). Quantitative imaging by pixel-based contrast-enhanced ultrasound reveals a linear relationship between synovial vascular perfusion and the recruitment of pathogenic IL-17A-F+IL-23+ CD161+ CD4+ T helper cells in psoriatic arthritis joints. Clinical Rheumatology. 36 (2), pp. 391-399. https://doi.org/10.1007/s10067-016-3500-xBoosting the Battery Life of Wearables for Health Monitoring Through the Compression of Biosignals
Hooshmand, M, Zordan, D, Del Testa, D, Grisan, E and Rossi, M (2017). Boosting the Battery Life of Wearables for Health Monitoring Through the Compression of Biosignals. IEEE Internet of Things Journal. 4, pp. 1647-1662. https://doi.org/10.1109/JIOT.2017.2689164Detection of a slow-flow component in contrast-enhanced ultrasound of the synovia for the differential diagnosis of arthritis
Rizzo, G, Tonietto, M, Castellaro, M, Raffeiner, B, Coran, A, Fiocco, U, Stramare, R and Grisan, E (2017). Detection of a slow-flow component in contrast-enhanced ultrasound of the synovia for the differential diagnosis of arthritis. SPIE Medical Imaging. Orlando, FL, USA 11 - 16 Feb 2017 SPIE. https://doi.org/10.1117/12.2250818Improving the quantification of contrast enhanced ultrasound using a Bayesian approach
Rizzo, G, Tonietto, M, Castellaro, M, Raffeiner, B, Coran, A, Fiocco, U, Stramare, R and Grisan, E (2017). Improving the quantification of contrast enhanced ultrasound using a Bayesian approach. SPIE Medical Imaging. Orlando, FL , USA 16 2016 - 11 Feb 2017 SPIE. https://doi.org/10.1117/12.2250195Superpixel-based classification of gastric chromoendoscopy images
Boschetto, D and Grisan, E (2017). Superpixel-based classification of gastric chromoendoscopy images. SPIE Medical Imaging. Orlando, FL, USA 11 - 16 Feb 2017 SPIE. https://doi.org/10.1117/12.2254187Boosted learned kernels for data-driven vesselness measure
Grisan, E (2017). Boosted learned kernels for data-driven vesselness measure. Proceedings Volume 10137, Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging; 101370Z (2017). Orlando, FL, USA 11 - 16 Feb 2017 SPIE. https://doi.org/10.1117/12.2250370Cortical Thickness variability in Multiple Sclerosis: The role of lesion segmentation and filling
Palombit, A, Castellaro, M, Calabrese, M, Romualdi, C, Pizzini, FB, Montemezzi, S, Grisan, E and Bertoldo, A (2017). Cortical Thickness variability in Multiple Sclerosis: The role of lesion segmentation and filling. 2017 IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017). Melbourne, VIC, Australia 18 - 21 Apr 2017 pp. 792-795 https://doi.org/10.1109/ISBI.2017.7950637From macro to nano: Linking quantitative CEUS perfusion parameters to CD4+ T cells subtypes in spondyloarthtitis
Grisan, E, Rizzo, G, Tonietto, M, Coran, A, Raffeiner, B, Scanu, A, Martini, V, Stramare, R and Fiocco, U (2017). From macro to nano: Linking quantitative CEUS perfusion parameters to CD4+ T cells subtypes in spondyloarthtitis. 2017 IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017). Melbourne, VIC, Australia 17 - 21 Apr 2017 IEEE. pp. 899-902 https://doi.org/10.1109/ISBI.2017.7950661Grade and location of power doppler are predictive of damage progression in rheumatoid arthritis patients in clinical remission by anti-tumour necrosis factor α
Raffeiner, B, Grisan, E, Botsios, C, Stramare, R, Rizzo, G, Bernardi, L, Punzi, L, Ometto, F and Doria, A (2017). Grade and location of power doppler are predictive of damage progression in rheumatoid arthritis patients in clinical remission by anti-tumour necrosis factor α. Rheumatology (United Kingdom). 56, pp. 1320-1325. https://doi.org/10.1093/rheumatology/kex084