The motor cortex of the sheep: laminar organization, projections and diffusion tensor imaging of the intracranial pyramidal and extrapyramidal tracts

Journal article


Peruffo, A., Corain, L., Bombardi, C., Centelleghe, C., Grisan, E., Graïc, J-M, Bontempi, P., Grandis, A. and Cozzi, B. (2019). The motor cortex of the sheep: laminar organization, projections and diffusion tensor imaging of the intracranial pyramidal and extrapyramidal tracts. Brain Structure and Function. 224 (5), pp. 1933-1946.
AuthorsPeruffo, A., Corain, L., Bombardi, C., Centelleghe, C., Grisan, E., Graïc, J-M, Bontempi, P., Grandis, A. and Cozzi, B.
Abstract

The laminar organization of the motor cortex of the sheep and other large domestic herbivores received scarce attention and is generally considered homologous to that of rodents and primates. Thickness of the cortex, subdivision into layers and organization are scarcely known. In the present study, we applied different modern morphological, mathematical and image-analyses techniques to the study of the motor area that controls movements of the forelimb in the sheep. The thickness of the cortex resulted comparable to that of other terrestrial Cetartiodactyls (but thicker than in marine Cetartiodactyls of similar body mass). The laminar organization showed marked development of layer 1, virtual absence of layer 4, and image analysis suggested prevalence of large irregular neural cells in the deeper layers. Diffusion tensor imaging revealed robust projections from the motor cortex to the pyramids in the brainstem, and well evident tracts descending to the tegmentum of the mesencephalon and dorsal pons. Our data contrast the general representation of the motor system of this species, considered to be predominantly based on extra-pyramidal tracts that originate from central pattern generators in the brainstem. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.

Year2019
JournalBrain Structure and Function
Journal citation224 (5), pp. 1933-1946
PublisherSpringer
ISSN1933-1946
Digital Object Identifier (DOI)doi:10.1007/s00429-019-01885-x
Publication dates
Print03 Jun 2019
Online14 May 2019
Publication process dates
Accepted24 Apr 2019
Deposited27 Nov 2019
Accepted author manuscript
License
CC BY 4.0
File Access Level
Open
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https://openresearch.lsbu.ac.uk/item/88966

Accepted author manuscript
BSAF-D-19-00037_R2.pdf
License: CC BY 4.0
File access level: Open

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