Xenotransplantation Clinical Trials and Equitable Patient Selection.

Journal article

Bobier, C. and Rodger, D. (2023). Xenotransplantation Clinical Trials and Equitable Patient Selection. Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees. https://doi.org/10.1017/S096318012300052X
AuthorsBobier, C. and Rodger, D.
AbstractXenotransplant patient selection recommendations restrict clinical trial participation to seriously ill patients for whom alternative therapies are unavailable or who will likely die while waiting for an allotransplant. Despite a scholarly consensus that this is advisable, we propose to examine this restriction. We offer three lines of criticism: (1) The risk-benefit calculation may well be unfavorable for seriously ill patients and society; (2) the guidelines conflict with criteria for equitable patient selection; and (3) the selection of seriously ill patients may compromise informed consent. We conclude by highlighting how the current guidance reveals a tension between the societal values of justice and beneficence.
Keywordsclinical trial; justice; fairness; xenotransplantation; ethics; allotransplantation; equity; research subjects; consent
Year2023
JournalCambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees
PublisherCambridge University Press (CUP)
ISSN1469-2147
Digital Object Identifier (DOI)https://doi.org/10.1017/S096318012300052X
Web address (URL)https://doi.org/10.1017/S096318012300052X
Publication dates
Online05 Oct 2023
Publication process dates
Accepted25 Aug 2023
Deposited18 Oct 2023
Accepted author manuscript
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Open
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