Prevalence and experience of fatigue in survivors of critical illness: a mixed‐methods systematic review

Journal article


Bench, S., Stayt, L., Shah, A., Dhiman, P. and Czuber‐Dochan, W. (2021). Prevalence and experience of fatigue in survivors of critical illness: a mixed‐methods systematic review. Anaesthesia. 76 (9), pp. 1233-1244. https://doi.org/10.1111/anae.15441
AuthorsBench, S., Stayt, L., Shah, A., Dhiman, P. and Czuber‐Dochan, W.
Abstract

We conducted a mixed methods systematic review to investigate the prevalence, experience and management of fatigue in survivors of critical illness. We identified 76 studies investigating fatigue or vitality in adults discharged from an ICU and extracted data were split into three datasets: vitality scores from the Short Form Health Survey SF-36 (n=54); other quantitative data (n=19); and qualitative data (n=9). We assessed methodological quality using critical appraisal skills programme tools. We adopted a segregated approach to mixed-methods synthesis. In a final step, we attributed combined results to one of four qualitative themes: prevalence and severity; contributing factors; impacts on quality of life; assessment and management. Prevalence of fatigue ranged from 13.8 to 80.9%. SF-36 vitality scores were commonly used as a marker of fatigue. Vitality scores reached a nadir approximately one-month post-ICU discharge (Mean (SD) 56.44 (32.30); 95%CI 52.92 - 59.97), improved over time but seldom reached reference population scores. Associated biological, disease-related and psychological factors included age, poor pre-morbid status, sleep and psychological disturbance. Qualitative data highlight the profound negative impact of fatigue on survivors’ quality of life. Survivors seldom had any information provided on the potential impact of fatigue. No fatigue assessment tools specific for critical illness or evidence-based interventions were reported. Fatigue is highly prevalent in survivors of critical illness and negatively impacts recovery. Further research on developing fatigue assessment tools specifically for critically ill patients and evaluating the impact of pharmacological and non-pharmacology interventions is needed.

KeywordsAnesthesiology and Pain Medicine
Year2021
JournalAnaesthesia
Journal citation76 (9), pp. 1233-1244
PublisherWiley
ISSN0003-2409
1365-2044
Digital Object Identifier (DOI)https://doi.org/10.1111/anae.15441
Publication dates
Print11 Mar 2021
Online11 Mar 2021
Publication process dates
Accepted13 Oct 2020
Deposited24 Oct 2020
Accepted author manuscript
File Access Level
Open
Additional information

This is the peer reviewed version of the following article: Bench, S (2020) Prevalence and experience of fatigue in survivors of critical illness: A mixed-methods systematic review, Anaesthesia. Which will be published in final form at https://associationofanaesthetists-publications.onlinelibrary.wiley.... This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

Licensehttp://onlinelibrary.wiley.com/termsAndConditions#vor
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