TRANSCUTANEOUS ELECTRICAL ACUPOINT STIMULATION IMPROVES THE OUTCOMES OF IN VITRO FERTILIZATION: A PROSPECTIVE, RANDOMIZED AND CONTROLLED STUDY

Journal article


Qu, F, Wang, F-F, Wu, Y, Zhou, J, Robinson, N., Hardiman, P, Pan, J-X, He, Y-J, Zhu, Y-H, Wang, H-Z, Ye, X-Q, He, K-L, Cui, L, Zhao, H-L and Ye, Y-H (2017). TRANSCUTANEOUS ELECTRICAL ACUPOINT STIMULATION IMPROVES THE OUTCOMES OF IN VITRO FERTILIZATION: A PROSPECTIVE, RANDOMIZED AND CONTROLLED STUDY. Explore: The Journal of Science & Healing.
AuthorsQu, F, Wang, F-F, Wu, Y, Zhou, J, Robinson, N., Hardiman, P, Pan, J-X, He, Y-J, Zhu, Y-H, Wang, H-Z, Ye, X-Q, He, K-L, Cui, L, Zhao, H-L and Ye, Y-H
Abstract

Objectives To explore whether transcutaneous electrical acupoint stimulation (TEAS) can improve the outcomes of in vitro fertilization (IVF). Design A prospective, randomized and controlled study. Setting IVF center in a university hospital. Participants Four hundred and eighty-one infertile patients with bilateral tubal blockage who were referred for IVF. Patients were randomized into four groups. Intervention TEAS was administered for 30 min, respectively at 24 h before TVOR and 2 h before ET. The acupoints included SP10 (Xuehai, bilateral), SP8 (Diji, bilateral), LR3 (Taichong, bilateral), ST36 (Zusanli, bilateral), EX-CA1 (Zigong, bilateral), RN4 (Guanyuan), PC6 (Neiguan, bilateral) and RN12 (Zhongwan). Based on different frequencies of TEAS, patients were grouped into a TEAS-2 Hz group, a TEAS-100 Hz group and a TEAS-2/100 Hz group. Patients in the control group only received routine IVF treatment and no TEAS were applied on them. Primary and secondary outcome measures The number of mature oocytes, normally fertilized oocytes and good-quality embryos were used to evaluate oocyte developmental competence of the patients. Data of clinical pregnancy rate (CPR), implantation rate (IR) and live birth rate (LBR) were also obtained. The levels of neuropeptide Y (NPY), transforming growth factor alpha and granulocyte colony-stimulating factor in the follicular fluids were measured with enzyme-linked immunosorbent assay (ELISA). Results No significant differences were found between the control, TEAS-2 Hz, TEAS-100 Hz and TEAS-2/100 Hz groups on the numbers of metaphase II oocytes, normally fertilized zygotes, early cleavage embryos or good quality embryos (P>0.05). However, the CPR, IR and LBR of the TEAS-2/100 Hz group were significantly higher than those of the other groups, respectively (P<0.05). The NPY levels in the follicular fluids of TEAS-2/100 Hz group were significantly higher than those of the other groups (P<0.05). Conclusion TEAS using a frequency of 2/100 Hz could help to improve the IVF outcomes partly by increasing NPY levels in the follicular fluids.

KeywordsTranscutaneous electrical acupoint stimulation (TEAS; in vitro fertilization (IVF); clinical pregnancy rate (CPR); implantation rate (IR); live birth rate (LBR).; 11 Medical And Health Sciences; Complementary & Alternative Medicine
Year2017
JournalExplore: The Journal of Science & Healing
PublisherElsevier BV
ISSN1550-8307
Digital Object Identifier (DOI)doi:10.1016/j.explore.2017.06.004
Publication dates
Print30 Jun 2017
Publication process dates
Deposited03 Jul 2017
Accepted04 Jun 2017
Accepted author manuscript
License
CC BY-NC-ND 4.0
Permalink -

https://openresearch.lsbu.ac.uk/item/86yx7

  • 4
    total views
  • 46
    total downloads
  • 0
    views this month
  • 2
    downloads this month

Related outputs

Factors influencing the quality of clinical trials on traditional Chinese medicine— Qualitative interviews with trial auditors, clinicians and academic researchers
Xue-yan Han, Xun Li, Ning Liang, Yuqian Yan, Ying Wang, Yutong Fei, Ying Zhang, Robinson, N. and Jian-Ping Liu Factors influencing the quality of clinical trials on traditional Chinese medicine— Qualitative interviews with trial auditors, clinicians and academic researchers. Complementary Therapies in Clinical Practice.
Parallel Robots with Homokinetic Joints: The Zero-Torsion Case
Wu, Y, Selig, J and Carricato, M (2019). Parallel Robots with Homokinetic Joints: The Zero-Torsion Case. 15th IFToMM World Congress. Krakov, Poland 30 Jun - 04 Jul 2019
An Overview of Systematic Reviews and Meta analyses on Acupuncture for Post-acute Stroke Dysphagia
Tian, Z-Y., Liao, X., Gao, Y., Liang, S-B., Zhang, C-Y., X, D-H., Liu, J-P. and Robinson, N. (2019). An Overview of Systematic Reviews and Meta analyses on Acupuncture for Post-acute Stroke Dysphagia. Geriatrics. 4 (4).
Chinese herbal medicine for patients living with HIV in Guangxi province, China: an analysis of two registries
Sun, J., Jiang, F., Wen, B., Liu, Z-W., Han, M., Robinson, N., McGrath, N., Fei, Y-T., Zhang, Y., Li, J., Li, W-Y., Deng, X. and Liu, J-P. (2019). Chinese herbal medicine for patients living with HIV in Guangxi province, China: an analysis of two registries. Scientific Reports.
A UK support network for maternity acupuncture: A survey of acupuncturists on the Acupuncture (For Conception to) Childbirth Team (ACT)
Betts, D., Armour, M. and Robinson, N. (2019). A UK support network for maternity acupuncture: A survey of acupuncturists on the Acupuncture (For Conception to) Childbirth Team (ACT). Medical Acupuncture. 31 (5), pp. 274-280.
Clinical effects and safety of Compound Glutamine Entersoluble Capsules for diarrhea-predominant irritable bowel syndrome: a systematic review and meta-analysis
Liang, S-B., Liang, C-H., Yang, S-H., Li, Y-Q., Tian, Z-Y., Robinson, N. and Liu, J. (2019). Clinical effects and safety of Compound Glutamine Entersoluble Capsules for diarrhea-predominant irritable bowel syndrome: a systematic review and meta-analysis. European Journal of Integrative Medicine.
Comparative efficacy of oral traditional Chinese patent medicine for acute cerebral infarction: protocol for network meta-analysis of randomized controlled trials
Cui, R., Xing, L., Robinson, N., Yu, D., Zhao, J. and Zhao, H. (2019). Comparative efficacy of oral traditional Chinese patent medicine for acute cerebral infarction: protocol for network meta-analysis of randomized controlled trials. European Journal of Integrative Medicine.
An Overview of Systematic Reviews of Acupuncture for Dysphagia Post-acute Stroke: a protocol
Tian, Z-Y, Liao, X., Gao, Y., Liang, S-B., Zhang, C-Y., Xu, D-H., Liu, J-P. and Robinson, N. (2019). An Overview of Systematic Reviews of Acupuncture for Dysphagia Post-acute Stroke: a protocol . European Journal of Integrative Medicine. 30, p. 100956.
The Use of Pattern Differentiation in WHO-Registered Traditional Chinese Medicine Trials – a systematic review
Zhang, X., Tian, R., Zhao, C., Birch, S., Lee, J.A., Alraek, T., Bovey, M., Zaslawski, C., Robinson, N., Kim, T-H., Lee, M.S. and Bian, Z-X. (2019). The Use of Pattern Differentiation in WHO-Registered Traditional Chinese Medicine Trials – a systematic review. European Journal of Integrative Medicine. 30, p. 100945.
Evaluation of outcomes reported in randomized controlled trials for herbal remedies for adults with chronic hepatitis C
Liu, J-P, Robinson, N., Liang, N, Liang, S, Yan, Y and Sun, Y (2019). Evaluation of outcomes reported in randomized controlled trials for herbal remedies for adults with chronic hepatitis C. Journal of Traditional Chinese Medical Sciences.
Children and Adults Tai Chi Study: a randomised feasibility study comparing internet delivered with face to face Tai Chi lessons in cystic fibrosis
Carr, S.B., Ronan, P., Lorenc, A., Mian, A., Madge, S. and Robinson, N. (2018). Children and Adults Tai Chi Study: a randomised feasibility study comparing internet delivered with face to face Tai Chi lessons in cystic fibrosis. European Respiratory Journal. 4 (4).
Transcutaneous electrical acupoint stimulation alleviates the anxiety levels of IVF: a prospective, randomized and controlled study
Xing, L-F, Wu, Y, Wang, F-F, Zhu, Y-H, Ma, C-M, Yan, Y-Y, Sun, S-J, Pan, J-X, Robinson, N., Hardiman, P and Qu, F (2018). Transcutaneous electrical acupoint stimulation alleviates the anxiety levels of IVF: a prospective, randomized and controlled study. European Journal of Integrative Medicine. 20, pp. 126-130.
Effects of acupuncture during in vitro fertilization or intracytoplasmic sperm injection: an updated systematic review and meta-analysis
Zhang, X, Lee, MS, Smith, CA, Robinson, N., Zhou, Y, Wu, Y, Mao, Y-Y and Qu, F (2018). Effects of acupuncture during in vitro fertilization or intracytoplasmic sperm injection: an updated systematic review and meta-analysis. European Journal of Integrative Medicine. 23, pp. 14-25.
Factors that influence patients’ decisions to discontinue with an acupuncture service—A qualitative study
Zanardelli, I and Robinson, N. (2018). Factors that influence patients’ decisions to discontinue with an acupuncture service—A qualitative study. European Journal of Integrative Medicine. 25, pp. 92-99.
Motion Interpolation in Lie Subgroups and Symmetric Subspaces
Selig, JM, Wu, Y and Carricato, M (2017). Motion Interpolation in Lie Subgroups and Symmetric Subspaces. 7th IFToMM International Workshop of Computational Kinematics. Futurescope, Poitiers, France 22 - 24 May 2017 London South Bank University. doi:http://doi.org/10.1007/978-3-319-60867-9_53
If music be the food of life – play on ?
Bonde, LO and Robinson, N. (2017). If music be the food of life – play on ? European Journal of Integrative Medicine. 9 (1).
Women’s health and Chinese integrative medicine
Qu, F, Wang, FF, Robinson, N. and Hardiman, P (2017). Women’s health and Chinese integrative medicine. Journal of Zhejiang University: Science B. 18 (3), pp. 183-185.
Acupuncture for treating polycystic ovary syndrome: guidance for future randomized controlled trials
Wu, Y, Robinson, N, Hardiman, P, Taw, MB, Zhou, J, Wang, FF and Qu, F (2016). Acupuncture for treating polycystic ovary syndrome: guidance for future randomized controlled trials. Journal of Zhejiang University: Science B. 17 (3), pp. 169 - 180.
The effects of acupuncture on polycystic ovary syndrome: A systematic review and meta-analysis
Qu, F., Yan, W., Hu, X-Y., Barry, J.A., Zhou, J., Wang, F-F., Ye, Y-H., Han, S-P., Li, R., Taw, M.B., Hardiman, P.J. and Robinson, N. (2016). The effects of acupuncture on polycystic ovary syndrome: A systematic review and meta-analysis. European Journal of Integrative Medicine. 8 (1), pp. 12-18.
The role of complementary and alternative medicine (CAM) in sexual and reproductive health
Qidwai, W, Wong, W, Nanji, K and Robinson, N. (2016). The role of complementary and alternative medicine (CAM) in sexual and reproductive health. European Journal of Integrative Medicine. 8 (1), pp. 1-3.
The Importance of Evidence for the Integration of Traditional and Complementary Medicine into Western Healthcare?
Robinson, N. (2016). The Importance of Evidence for the Integration of Traditional and Complementary Medicine into Western Healthcare? World Journal of Traditional Chinese Medicine. 2 (1), pp. 74 - 79.
Harmonising data collection from osteoarthritis studies to enable stratification: Recommendations on core data collection from an Arthritis Research UK clinical studies group
Kingsbury, SR, Corp, N, Watt, FE, Felson, DT, O'Neill, TW, Holt, CA, Jones, RK, Conaghan, PG, Arden, NK, Adams, J, Appleyard, I, Birrell, F, Blank, M, Callaghan, MJ, Cumming, J, Chapman, GJ, Halstead, J, Hamilton, DF, Hurley, M, Martin, K, Mason, DJ, Nuki, G, Redmond, AC, Reilly, K, Robinson, N., Roddy, E, Simpson, H, Smith, TO, Thomas, C, Thomas, E, Wilkinson, J and Wise, E (2016). Harmonising data collection from osteoarthritis studies to enable stratification: Recommendations on core data collection from an Arthritis Research UK clinical studies group. Rheumatology (United Kingdom). 55 (8), pp. 1394-1402.
Introducing “Evidence for clinical practice” [Editorial]
Alper, BS, Malone-Moses, M, Manheimer, EW and Robinson, N. (2016). Introducing “Evidence for clinical practice” [Editorial]. European Journal of Integrative Medicine. 8 (3), pp. 147-149.
Pediatric integrative medicine needs research evidence to guide decision-making
Gardiner, P and Robinson, N. (2016). Pediatric integrative medicine needs research evidence to guide decision-making. European Journal of Integrative Medicine. 8 (2), pp. 79 - 80.
Bromelain and Cardiovascular Risk Factors in Diabetes: An Exploratory Randomized, Placebo Controlled, Double Blind Clinical Trial
Ley, C., NI, Q, Liao, X, Gao, H-L and Robinson, N. (2016). Bromelain and Cardiovascular Risk Factors in Diabetes: An Exploratory Randomized, Placebo Controlled, Double Blind Clinical Trial. Chinese Journal of Integrative Medicine. 22 (10), pp. 728-737.
General Practitioners’ use of and attitudes to acupuncture in relation to the UK’s National Institute for Health and Care Excellence (NICE) clinical guidelines—A pilot study
Czarnawska-Iliev, I and Robinson, N. (2016). General Practitioners’ use of and attitudes to acupuncture in relation to the UK’s National Institute for Health and Care Excellence (NICE) clinical guidelines—A pilot study. European Journal of Integrative Medicine. 8 (4).
Evidence is in the Eye of the Beholder: The case of the 2016 draft NICE Guidelines for Low Back Pain [editorial]
Hopper Koppelman, M, Bovey, M and Robinson, N. (2016). Evidence is in the Eye of the Beholder: The case of the 2016 draft NICE Guidelines for Low Back Pain [editorial]. European Journal of Integrative Medicine. 8 (4).
Common mistakes when using plant names and how to avoid them
Dauncey, EA, Irving, J, Allkin, R and Robinson, N. (2016). Common mistakes when using plant names and how to avoid them. European Journal of Integrative Medicine. 8 (5), pp. 597-601.
Integrating acupuncture: are there positive health outcomes for women?
Robinson, N. (2016). Integrating acupuncture: are there positive health outcomes for women? Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology). 18 (3), pp. 233-238.
Traditional Chinese Medicine - challenges for research
Robinson, N. (2015). Traditional Chinese Medicine - challenges for research. in: McCarthy, P.W. and Langweiler, M. (ed.) Methodologies for Effectively Assessing Complementary and Alternative Medicine (CAM) London Singing Dragon.
Acupuncture for the treatment of phantom limb syndrome in lower limb amputees: a randomised controlled feasibility study
Trevelyan, EG, Turner, WA, Summerfield-Mann, L and Robinson, N. (2015). Acupuncture for the treatment of phantom limb syndrome in lower limb amputees: a randomised controlled feasibility study. Trials.
The politics of integrative medicine: The case of CAM
Saks, M and Robinson, N. (2015). The politics of integrative medicine: The case of CAM. European Journal of Integrative Medicine. 7 (6), pp. 557-560.
A systematic review of experimental and clinical acupuncture in chemotherapy-induced peripheral neuropathy.
Franconi, G, Manni, L, Schröder, S, Marchetti, P and Robinson, N. (2013). A systematic review of experimental and clinical acupuncture in chemotherapy-induced peripheral neuropathy. Evid Based Complement Alternat Med. 2013, p. 516916.