The Use of Pattern Differentiation in WHO-Registered Traditional Chinese Medicine Trials – a systematic review

Journal article


Zhang, X., Tian, R., Zhao, C., Birch, S., Lee, J.A., Alraek, T., Bovey, M., Zaslawski, C., Robinson, N., Kim, T-H., Lee, M.S. and Bian, Z-X. (2019). The Use of Pattern Differentiation in WHO-Registered Traditional Chinese Medicine Trials – a systematic review. European Journal of Integrative Medicine. 30, p. 100945.
AuthorsZhang, X., Tian, R., Zhao, C., Birch, S., Lee, J.A., Alraek, T., Bovey, M., Zaslawski, C., Robinson, N., Kim, T-H., Lee, M.S. and Bian, Z-X.
Abstract

Introduction: Pattern differentiation is a critical component for traditional Chinese medicine (TCM) diagnosis and treatment. However, the issue of whether pattern
differentiation is appropriately applied in TCM Interventional trials, including Chinese herbal medicine (CHM) interventions and non-herbal TCM interventions, is unclear. The aim of this study was to i) systematically review the current status of pattern differentiation used in WHO-registered clinical trials for different types of TCM
interventions; and ii) provide suggestions for improving the use of pattern differentiation in future clinical trial design.
Methods: The World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) database was searched for all TCM interventional trials registered up to 31 December 2017. In this systematic review trials with a TCM pattern differentiation in their design were included. Descriptive statistics were collated to demonstrate the characteristics of pattern differentiation applied for different TCM interventional trials.
Results: Among 2,955 TCM interventional trials registered during 1999-2017, 376 (12.7%) trials included pattern differentiation. Of 376 trials, the use of pattern differentiation was identified in –title (30.6%), objective (50.5%), participants inclusion 4 (100%), outcomes (43.6%) and study background (12.5%). Further, 85.4% reported
the specific name of the TCM intervention, 10.6% provided the intervention’s targeted pattern, 83.8% reported the specific name of the TCM pattern, 7.2% presented diagnostic criteria for the pattern studied, and 19.1% adopted a pattern-related
outcome as primary outcome for evaluation.
Conclusion: The reporting and application of pattern differentiation in TCM trials were inadequate and confusing, which was mainly due to lack of clarity regarding study
design, objectives, diagnostic criteria and outcomes.

Year2019
JournalEuropean Journal of Integrative Medicine
Journal citation30, p. 100945
PublisherElsevier
ISSN1876-3820
Digital Object Identifier (DOI)doi:10.1016/j.eujim.2019.100945
Publication dates
Online21 Jul 2019
Publication process dates
Accepted19 Jul 2019
Deposited10 Sep 2019
Accepted author manuscript
License
CC BY-NC-ND 4.0
File Access Level
Open
Permalink -

https://openresearch.lsbu.ac.uk/item/87zy9

Accepted author manuscript

  • 2
    total views
  • 0
    total downloads
  • 1
    views this month
  • 0
    downloads this month

Related outputs

Factors influencing the quality of clinical trials on traditional Chinese medicine— Qualitative interviews with trial auditors, clinicians and academic researchers
Xue-yan Han, Xun Li, Ning Liang, Yuqian Yan, Ying Wang, Yutong Fei, Ying Zhang, Robinson, N. and Jian-Ping Liu Factors influencing the quality of clinical trials on traditional Chinese medicine— Qualitative interviews with trial auditors, clinicians and academic researchers. Complementary Therapies in Clinical Practice.
Comparative efficacy of oral traditional Chinese patent medicine for acute cerebral infarction: protocol for network meta-analysis of randomized controlled trials
Cui, R., Xing, L., Robinson, N., Yu, D., Zhao, J. and Zhao, H. (2019). Comparative efficacy of oral traditional Chinese patent medicine for acute cerebral infarction: protocol for network meta-analysis of randomized controlled trials. European Journal of Integrative Medicine.
An Overview of Systematic Reviews of Acupuncture for Dysphagia Post-acute Stroke: a protocol
Tian, Z-Y, Liao, X., Gao, Y., Liang, S-B., Zhang, C-Y., Xu, D-H., Liu, J-P. and Robinson, N. (2019). An Overview of Systematic Reviews of Acupuncture for Dysphagia Post-acute Stroke: a protocol . European Journal of Integrative Medicine. 30, p. 100956.
Evaluation of outcomes reported in randomized controlled trials for herbal remedies for adults with chronic hepatitis C
Liu, J-P, Robinson, N., Liang, N, Liang, S, Yan, Y and Sun, Y (2019). Evaluation of outcomes reported in randomized controlled trials for herbal remedies for adults with chronic hepatitis C. Journal of Traditional Chinese Medical Sciences.
Children and Adults Tai Chi Study: a randomised feasibility study comparing internet delivered with face to face Tai Chi lessons in cystic fibrosis
Carr, S.B., Ronan, P., Lorenc, A., Mian, A., Madge, S. and Robinson, N. (2018). Children and Adults Tai Chi Study: a randomised feasibility study comparing internet delivered with face to face Tai Chi lessons in cystic fibrosis. European Respiratory Journal. 4 (4).
Transcutaneous electrical acupoint stimulation alleviates the anxiety levels of IVF: a prospective, randomized and controlled study
Xing, L-F, Wu, Y, Wang, F-F, Zhu, Y-H, Ma, C-M, Yan, Y-Y, Sun, S-J, Pan, J-X, Robinson, N., Hardiman, P and Qu, F (2018). Transcutaneous electrical acupoint stimulation alleviates the anxiety levels of IVF: a prospective, randomized and controlled study. European Journal of Integrative Medicine. 20, pp. 126-130.
Effects of acupuncture during in vitro fertilization or intracytoplasmic sperm injection: an updated systematic review and meta-analysis
Zhang, X, Lee, MS, Smith, CA, Robinson, N., Zhou, Y, Wu, Y, Mao, Y-Y and Qu, F (2018). Effects of acupuncture during in vitro fertilization or intracytoplasmic sperm injection: an updated systematic review and meta-analysis. European Journal of Integrative Medicine. 23, pp. 14-25.
Factors that influence patients’ decisions to discontinue with an acupuncture service—A qualitative study
Zanardelli, I and Robinson, N. (2018). Factors that influence patients’ decisions to discontinue with an acupuncture service—A qualitative study. European Journal of Integrative Medicine. 25, pp. 92-99.
If music be the food of life – play on ?
Bonde, LO and Robinson, N. (2017). If music be the food of life – play on ? European Journal of Integrative Medicine. 9 (1).
Women’s health and Chinese integrative medicine
Qu, F, Wang, FF, Robinson, N. and Hardiman, P (2017). Women’s health and Chinese integrative medicine. Journal of Zhejiang University: Science B. 18 (3), pp. 183-185.
TRANSCUTANEOUS ELECTRICAL ACUPOINT STIMULATION IMPROVES THE OUTCOMES OF IN VITRO FERTILIZATION: A PROSPECTIVE, RANDOMIZED AND CONTROLLED STUDY
Qu, F, Wang, F-F, Wu, Y, Zhou, J, Robinson, N., Hardiman, P, Pan, J-X, He, Y-J, Zhu, Y-H, Wang, H-Z, Ye, X-Q, He, K-L, Cui, L, Zhao, H-L and Ye, Y-H (2017). TRANSCUTANEOUS ELECTRICAL ACUPOINT STIMULATION IMPROVES THE OUTCOMES OF IN VITRO FERTILIZATION: A PROSPECTIVE, RANDOMIZED AND CONTROLLED STUDY. Explore: The Journal of Science & Healing.
The role of complementary and alternative medicine (CAM) in sexual and reproductive health
Qidwai, W, Wong, W, Nanji, K and Robinson, N. (2016). The role of complementary and alternative medicine (CAM) in sexual and reproductive health. European Journal of Integrative Medicine. 8 (1), pp. 1-3.
The Importance of Evidence for the Integration of Traditional and Complementary Medicine into Western Healthcare?
Robinson, N. (2016). The Importance of Evidence for the Integration of Traditional and Complementary Medicine into Western Healthcare? World Journal of Traditional Chinese Medicine. 2 (1), pp. 74 - 79.
Harmonising data collection from osteoarthritis studies to enable stratification: Recommendations on core data collection from an Arthritis Research UK clinical studies group
Kingsbury, SR, Corp, N, Watt, FE, Felson, DT, O'Neill, TW, Holt, CA, Jones, RK, Conaghan, PG, Arden, NK, Adams, J, Appleyard, I, Birrell, F, Blank, M, Callaghan, MJ, Cumming, J, Chapman, GJ, Halstead, J, Hamilton, DF, Hurley, M, Martin, K, Mason, DJ, Nuki, G, Redmond, AC, Reilly, K, Robinson, N., Roddy, E, Simpson, H, Smith, TO, Thomas, C, Thomas, E, Wilkinson, J and Wise, E (2016). Harmonising data collection from osteoarthritis studies to enable stratification: Recommendations on core data collection from an Arthritis Research UK clinical studies group. Rheumatology (United Kingdom). 55 (8), pp. 1394-1402.
Introducing “Evidence for clinical practice” [Editorial]
Alper, BS, Malone-Moses, M, Manheimer, EW and Robinson, N. (2016). Introducing “Evidence for clinical practice” [Editorial]. European Journal of Integrative Medicine. 8 (3), pp. 147-149.
Pediatric integrative medicine needs research evidence to guide decision-making
Gardiner, P and Robinson, N. (2016). Pediatric integrative medicine needs research evidence to guide decision-making. European Journal of Integrative Medicine. 8 (2), pp. 79 - 80.
Bromelain and Cardiovascular Risk Factors in Diabetes: An Exploratory Randomized, Placebo Controlled, Double Blind Clinical Trial
Ley, C., NI, Q, Liao, X, Gao, H-L and Robinson, N. (2016). Bromelain and Cardiovascular Risk Factors in Diabetes: An Exploratory Randomized, Placebo Controlled, Double Blind Clinical Trial. Chinese Journal of Integrative Medicine. 22 (10), pp. 728-737.
General Practitioners’ use of and attitudes to acupuncture in relation to the UK’s National Institute for Health and Care Excellence (NICE) clinical guidelines—A pilot study
Czarnawska-Iliev, I and Robinson, N. (2016). General Practitioners’ use of and attitudes to acupuncture in relation to the UK’s National Institute for Health and Care Excellence (NICE) clinical guidelines—A pilot study. European Journal of Integrative Medicine. 8 (4).
Evidence is in the Eye of the Beholder: The case of the 2016 draft NICE Guidelines for Low Back Pain [editorial]
Hopper Koppelman, M, Bovey, M and Robinson, N. (2016). Evidence is in the Eye of the Beholder: The case of the 2016 draft NICE Guidelines for Low Back Pain [editorial]. European Journal of Integrative Medicine. 8 (4).
Common mistakes when using plant names and how to avoid them
Dauncey, EA, Irving, J, Allkin, R and Robinson, N. (2016). Common mistakes when using plant names and how to avoid them. European Journal of Integrative Medicine. 8 (5), pp. 597-601.
Integrating acupuncture: are there positive health outcomes for women?
Robinson, N. (2016). Integrating acupuncture: are there positive health outcomes for women? Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology). 18 (3), pp. 233-238.
Acupuncture for the treatment of phantom limb syndrome in lower limb amputees: a randomised controlled feasibility study
Trevelyan, EG, Turner, WA, Summerfield-Mann, L and Robinson, N. (2015). Acupuncture for the treatment of phantom limb syndrome in lower limb amputees: a randomised controlled feasibility study. Trials.
The politics of integrative medicine: The case of CAM
Saks, M and Robinson, N. (2015). The politics of integrative medicine: The case of CAM. European Journal of Integrative Medicine. 7 (6), pp. 557-560.
A systematic review of experimental and clinical acupuncture in chemotherapy-induced peripheral neuropathy.
Franconi, G, Manni, L, Schröder, S, Marchetti, P and Robinson, N. (2013). A systematic review of experimental and clinical acupuncture in chemotherapy-induced peripheral neuropathy. Evid Based Complement Alternat Med. 2013, p. 516916.