The effect of e-cigarettes on smoking cessation and cigarette smoking initiation: An evidence-based rapid review and meta-analysis.
Journal article
Zhang, Y-Y., Bu, F-L., Dong, F., Wang, J-H., Zhu, S-J., Zhang, X.-W., Robinson, N. and Liu, J-P. (2021). The effect of e-cigarettes on smoking cessation and cigarette smoking initiation: An evidence-based rapid review and meta-analysis. Tobacco induced diseases. 19, p. 04. https://doi.org/10.18332/tid/131624
| Authors | Zhang, Y-Y., Bu, F-L., Dong, F., Wang, J-H., Zhu, S-J., Zhang, X.-W., Robinson, N. and Liu, J-P. |
|---|---|
| Abstract | The contribution made by e-cigarettes to smoking cessation continues to be controversial. Reports suggest that teenagers are becoming increasingly addicted to e-cigarettes and that e-cigarette use in adolescents is associated with subsequent cigarette smoking. Systematic searches of eleven databases were conducted (January 2015 to June 2020). Systematic reviews, randomized controlled trials (RCTs) and cohort studies comparing e-cigarettes with placebo e-cigarettes, nicotine replacement therapy (NRT) or no e-cigarette use were included. The two primary outcomes were smoking cessation among smokers and smoking initiation among non-smoking teenagers. The secondary outcome was adverse events. Data were synthesized using risk ratio (RR) or adjusted odds ratio (AOR) with 95% confidence interval (CI). Six systematic reviews, 5 RCTs and 24 cohort studies were identified. For smoking cessation, findings from 4 systematic reviews indicated that e-cigarettes contributed to cessation while one found the opposite. Meta-analysis of 5 RCTs suggested that e-cigarettes were superior to NRT or placebo for smoking cessation (RR=1.55; 95% CI: 1.00-2.40; I =57.6%; low certainty; 5 trials, n=4025). Evidence from 9 cohort studies showed that e-cigarette use was not associated with cessation (AOR=1.16; 95% CI: 0.88-1.54; I =69.0%; n=22220). Subgroup analysis suggested that intensive e-cigarette use may be associated with cessation. In terms of smoking initiation, adolescents who ever used e-cigarettes had a greater risk for smoking initiation than non-users (AOR=2.91; 95% CI: 2.61-3.23; I =61.0%; 15 trials, n=68943), the findings were consistent with one included systematic review. No serious adverse events were reported in the included studies. Low certainty evidence suggests that e-cigarettes appear to be potentially effective for smoking cessation. The use of e-cigarettes in adolescents may be associated with smoking initiation. No serious adverse events were reported. [Abstract copyright: © 2021 Zhang Y.Y. et al.] |
| Keywords | e-cigarettes; rapid review; smoking cessation; smoking initiation; systematic review |
| Year | 2021 |
| Journal | Tobacco induced diseases |
| Journal citation | 19, p. 04 |
| ISSN | 1617-9625 |
| Digital Object Identifier (DOI) | https://doi.org/10.18332/tid/131624 |
| https://doi.org/04 | |
| Publication dates | |
| Online | 13 Jan 2021 |
| Publication process dates | |
| Accepted | 12 Dec 2020 |
| Deposited | 01 Feb 2021 |
| Publisher's version | License File Access Level Open |
Permalink -
https://openresearch.lsbu.ac.uk/item/8vz37
Download files
154
total views100
total downloads2
views this month1
downloads this month