Traditional Chinese medicine for smoking cessation: An umbrella review of systematic reviews and meta-analysis of randomized controlled trials.
Journal article
Lu, Chun-Li, Jin, Xin-Yan, Wang, Qian-Yun, Chen, Xiao-Ying, Zheng, Ruo-Xiang, Wang, Chao-Jie, Jiang, Jing-Jing, Qiao, Shu-Yu, Yang, Si-Hong, Zhang, Wei-Han, Chen, Si-Yi, Li, Jia-Xuan, Liu, Xue-Han, Suo, Yu-Si, Wang, Jian-Hua, Xue, Xue, Liang, Li-Rong, Robinson, Nicola and Liu, Jian-Ping (2023). Traditional Chinese medicine for smoking cessation: An umbrella review of systematic reviews and meta-analysis of randomized controlled trials. Tobacco induced diseases. 21, p. 150. https://doi.org/10.18332/tid/174090
Authors | Lu, Chun-Li, Jin, Xin-Yan, Wang, Qian-Yun, Chen, Xiao-Ying, Zheng, Ruo-Xiang, Wang, Chao-Jie, Jiang, Jing-Jing, Qiao, Shu-Yu, Yang, Si-Hong, Zhang, Wei-Han, Chen, Si-Yi, Li, Jia-Xuan, Liu, Xue-Han, Suo, Yu-Si, Wang, Jian-Hua, Xue, Xue, Liang, Li-Rong, Robinson, Nicola and Liu, Jian-Ping |
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Abstract | Traditional Chinese medicine (TCM) may have special advantages in facilitating smoking cessation, but consensus on effectiveness is lacking. We aim to comprehensively review, update, and refine current evidence on TCM effectiveness and safety. Nine databases were searched from their inception up to 28 February 2023. Systematic reviews (SRs) and meta-analysis of TCM for smoking cessation were identified and retrieved. Additional databases and hand searches of RCTs from included SRs were performed for data pooling. Cochrane ROB tools and AMSTAR-2 were used to evaluate the methodological quality of RCTs and SRs, respectively. RCT data are presented as relative risks (RR) or mean differences (MD) with 95% confidence intervals (CI) using RevMan 5.4. Thirteen SRs involving 265 studies with 33081 participants were included. Among these 265 studies, 157 were duplicates (58.36%) and 52 were non-RCTs (19.62%). Combined with the remaining 56 RCTs identified through hand searches, 88 RCTs involving 12434 participants were finally included for data synthesis. All the SRs focused on acupoint stimulation, and the majority were of low or very low quality. The methodological quality of RCTs was either unclear or high risk. For continuous abstinence rate, TCM external interventions were better than placebo in 6 months to 1 year (RR=1.60; 95% CI: 1.14-2.25; I =27%; n=5533 participants). Compared with placebo, TCM external application was effective in reducing nicotine withdrawal symptoms, and the effect was gradually stable and obvious in the fourth week (MD= -4.46; 95% CI: -5.43 - -3.49; n=165 participants). Twelve RCTs reported adverse events as outcome indicators for safety evaluation, and no serious adverse events occurred. Despite the methodological limitations of the original studies, our review suggests that TCM intervention shows potential effectiveness on the continuous abstinence rate. Extending the intervention time can enhance the effect of TCM on nicotine withdrawal symptoms. Referred to adverse events, more data for safety evaluation are required. [Abstract copyright: © 2023 Lu CL. et al.] |
Keywords | acupoint stimulation; tobacco withdrawal syndrome; traditional Chinese medicine; smoking cessation; systematic review |
Year | 2023 |
Journal | Tobacco induced diseases |
Journal citation | 21, p. 150 |
Publisher | European Publishing |
ISSN | 1617-9625 |
Digital Object Identifier (DOI) | https://doi.org/10.18332/tid/174090 |
https://doi.org/150 | |
Publication dates | |
Online | 15 Nov 2023 |
Publication process dates | |
Accepted | 16 Oct 2023 |
Deposited | 29 Jan 2024 |
Publisher's version | License File Access Level Open |
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https://openresearch.lsbu.ac.uk/item/96388
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