Evaluation of outcomes reported in randomized controlled trials for herbal remedies for adults with chronic hepatitis C

Journal article


Liu, J-P, Robinson, N., Liang, N, Liang, S, Yan, Y and Sun, Y (2019). Evaluation of outcomes reported in randomized controlled trials for herbal remedies for adults with chronic hepatitis C. Journal of Traditional Chinese Medical Sciences. 6 (2), pp. 115-121.
AuthorsLiu, J-P, Robinson, N., Liang, N, Liang, S, Yan, Y and Sun, Y
Abstract

Background: Herbal remedies have been widely utilized in treating chronic hepatitis C (CHC) worldwide. Selecting appropriate outcomes to reflect both beneficial and harmful effects is a crucial step in designing randomized controlled trials (RCTs). This study evaluated the outcomes reported in RCTs on herbal remedies for CHC with comparison to the core outcomes recommended by the Cochrane Hepato-Biliary Group
(CHBG), to check the consistency of the outcomes and to provide recommendation for future researches.
Methods: A systematic literature search was conducted in Western and Chinese databases to identify RCTs on herbal remedies for adults with CHC. For each trial, all the outcomes reported in the results section were collected. Comparison between trial outcomes and CHBG core outcomes were evaluated and summarized with descriptive statistics.
Results: A total of 116 RCTs involving 9154 participants were included; 27 outcomes were identified. Commonly reported outcomes included alanine aminotransferase (64
trials, 55.2%), adverse events (58 trials, 50.0%), and end-of-treatment virological response (50 trials, 43.1%). All trials indicated that the herbal remedies under investigation had a positive effect and was markedly more effective than the control.
Nearly half of the trials reported that the combination of herbal medicine and antiviral drugs could ameliorate adverse events. Very few trials reported primary core outcomes relating survival and quality of life. The most frequently reported core outcomes are non-serious adverse events (54 trials, 46.6%), viral response (27 trials, 23.3%), and biochemical response (24 trials, 20.7%).
Conclusion: The variation and inconsistency in trial outcomes impedes research synthesis efforts, and indicate the need for comparable outcomes through the development of core outcome sets in CHC. The low concordance of outcome reporting
could be improved by following CHBG core outcomes recommendation.

Year2019
JournalJournal of Traditional Chinese Medical Sciences
Journal citation6 (2), pp. 115-121
PublisherElsevier
Digital Object Identifier (DOI)doi:10.1016/j.jtcms.2019.03.002
Web address (URL)https://www.sciencedirect.com/science/article/pii/S209575481830187X
Publication dates
Print13 Apr 2019
Publication process dates
Deposited19 Mar 2019
Accepted13 Mar 2019
Accepted author manuscript
License
CC BY-NC-ND 4.0
File Access Level
Open
Permalink -

https://openresearch.lsbu.ac.uk/item/866y6

Accepted author manuscript

  • 15
    total views
  • 0
    total downloads
  • 2
    views this month
  • 0
    downloads this month

Related outputs

Motor entry point acupuncture for shoulder abduction dysfunction after stroke: a randomized controlled feasibility trial
Lin, Z., Zhang, Y., Gao, X., Xing, Y., Hu, X-Y. and Robinson, N. (2020). Motor entry point acupuncture for shoulder abduction dysfunction after stroke: a randomized controlled feasibility trial. European Journal of Integrative Medicine.
Can Chinese Medicine Be Used for Prevention of Corona Virus Disease 2019 (COVID-19)? A Review of Historical Classics, Research Evidence and Current Prevention Programs
Luo, H., Tang, Q-L., Shang, Y-X., Liang, S-B., Yang, M., Robinson, N. and Liu, J-P. (2020). Can Chinese Medicine Be Used for Prevention of Corona Virus Disease 2019 (COVID-19)? A Review of Historical Classics, Research Evidence and Current Prevention Programs. Chinese Journal of Integrative Medicine.
Acupuncture for stroke: perceptions and possibilities
Robinson, N., Ye, T, Ronan, P, Garbelli, PE and Smithard, D (2019). Acupuncture for stroke: perceptions and possibilities. Acupuncture in medicine.
The potential effects and use of Chinese herbal medicine pine pollen (Pinus Pollen) : a bibliometric analysis of pharmacological and clinical studies
Liang, S-B, Liang, N, Bu, F-L, Lai, B-Y, Zhang, Y-P, Cao, H-J, Fei, Y-T, Robinson, N and Liu, J-P (2019). The potential effects and use of Chinese herbal medicine pine pollen (Pinus Pollen) : a bibliometric analysis of pharmacological and clinical studies. World Journal of Traditional Chinese Medicine.
An Overview of Systematic Reviews and Meta analyses on Acupuncture for Post-acute Stroke Dysphagia
Tian, Z-Y., Liao, X., Gao, Y., Liang, S-B., Zhang, C-Y., X, D-H., Liu, J-P. and Robinson, N. (2019). An Overview of Systematic Reviews and Meta analyses on Acupuncture for Post-acute Stroke Dysphagia. Geriatrics. 4 (4).
Chinese herbal medicine for patients living with HIV in Guangxi province, China: an analysis of two registries
Sun, J., Jiang, F., Wen, B., Liu, Z-W., Han, M., Robinson, N., McGrath, N., Fei, Y-T., Zhang, Y., Li, J., Li, W-Y., Deng, X. and Liu, J-P. (2019). Chinese herbal medicine for patients living with HIV in Guangxi province, China: an analysis of two registries. Scientific Reports. 9, p. 17444.
A UK support network for maternity acupuncture: A survey of acupuncturists on the Acupuncture (For Conception to) Childbirth Team (ACT)
Betts, D., Armour, M. and Robinson, N. (2019). A UK support network for maternity acupuncture: A survey of acupuncturists on the Acupuncture (For Conception to) Childbirth Team (ACT). Medical Acupuncture. 31 (5), pp. 274-280.
Clinical effects and safety of Compound Glutamine Entersoluble Capsules for diarrhea-predominant irritable bowel syndrome: a systematic review and meta-analysis
Liang, S-B., Liang, C-H., Yang, S-H., Li, Y-Q., Tian, Z-Y., Robinson, N. and Liu, J. (2019). Clinical effects and safety of Compound Glutamine Entersoluble Capsules for diarrhea-predominant irritable bowel syndrome: a systematic review and meta-analysis. European Journal of Integrative Medicine.
Comparative efficacy of oral traditional Chinese patent medicine for acute cerebral infarction: protocol for network meta-analysis of randomized controlled trials
Cui, R., Xing, L., Robinson, N., Yu, D., Zhao, J. and Zhao, H. (2019). Comparative efficacy of oral traditional Chinese patent medicine for acute cerebral infarction: protocol for network meta-analysis of randomized controlled trials. European Journal of Integrative Medicine.
An Overview of Systematic Reviews of Acupuncture for Dysphagia Post-acute Stroke: a protocol
Tian, Z-Y, Liao, X., Gao, Y., Liang, S-B., Zhang, C-Y., Xu, D-H., Liu, J-P. and Robinson, N. (2019). An Overview of Systematic Reviews of Acupuncture for Dysphagia Post-acute Stroke: a protocol . European Journal of Integrative Medicine. 30, p. 100956.
Factors influencing the quality of clinical trials on traditional Chinese medicine— Qualitative interviews with trial auditors, clinicians and academic researchers
Xue-yan Han, Xun Li, Ning Liang, Yuqian Yan, Ying Wang, Yutong Fei, Ying Zhang, Robinson, N. and Jian-Ping Liu (2019). Factors influencing the quality of clinical trials on traditional Chinese medicine— Qualitative interviews with trial auditors, clinicians and academic researchers. Complementary Therapies in Clinical Practice. 37, pp. 109-114.
The Use of Pattern Differentiation in WHO-Registered Traditional Chinese Medicine Trials – a systematic review
Zhang, X., Tian, R., Zhao, C., Birch, S., Lee, J.A., Alraek, T., Bovey, M., Zaslawski, C., Robinson, N., Kim, T-H., Lee, M.S. and Bian, Z-X. (2019). The Use of Pattern Differentiation in WHO-Registered Traditional Chinese Medicine Trials – a systematic review. European Journal of Integrative Medicine. 30, p. 100945.
Children and Adults Tai Chi Study: a randomised feasibility study comparing internet delivered with face to face Tai Chi lessons in cystic fibrosis
Carr, S.B., Ronan, P., Lorenc, A., Mian, A., Madge, S. and Robinson, N. (2018). Children and Adults Tai Chi Study: a randomised feasibility study comparing internet delivered with face to face Tai Chi lessons in cystic fibrosis. European Respiratory Journal. 4 (4).
Transcutaneous electrical acupoint stimulation alleviates the anxiety levels of IVF: a prospective, randomized and controlled study
Xing, L-F, Wu, Y, Wang, F-F, Zhu, Y-H, Ma, C-M, Yan, Y-Y, Sun, S-J, Pan, J-X, Robinson, N., Hardiman, P and Qu, F (2018). Transcutaneous electrical acupoint stimulation alleviates the anxiety levels of IVF: a prospective, randomized and controlled study. European Journal of Integrative Medicine. 20, pp. 126-130.
Effects of acupuncture during in vitro fertilization or intracytoplasmic sperm injection: an updated systematic review and meta-analysis
Zhang, X, Lee, MS, Smith, CA, Robinson, N., Zhou, Y, Wu, Y, Mao, Y-Y and Qu, F (2018). Effects of acupuncture during in vitro fertilization or intracytoplasmic sperm injection: an updated systematic review and meta-analysis. European Journal of Integrative Medicine. 23, pp. 14-25.
Factors that influence patients’ decisions to discontinue with an acupuncture service—A qualitative study
Zanardelli, I and Robinson, N. (2018). Factors that influence patients’ decisions to discontinue with an acupuncture service—A qualitative study. European Journal of Integrative Medicine. 25, pp. 92-99.
If music be the food of life – play on ?
Bonde, LO and Robinson, N. (2017). If music be the food of life – play on ? European Journal of Integrative Medicine. 9 (1).
Women’s health and Chinese integrative medicine
Qu, F, Wang, FF, Robinson, N. and Hardiman, P (2017). Women’s health and Chinese integrative medicine. Journal of Zhejiang University: Science B. 18 (3), pp. 183-185.
TRANSCUTANEOUS ELECTRICAL ACUPOINT STIMULATION IMPROVES THE OUTCOMES OF IN VITRO FERTILIZATION: A PROSPECTIVE, RANDOMIZED AND CONTROLLED STUDY
Qu, F, Wang, F-F, Wu, Y, Zhou, J, Robinson, N., Hardiman, P, Pan, J-X, He, Y-J, Zhu, Y-H, Wang, H-Z, Ye, X-Q, He, K-L, Cui, L, Zhao, H-L and Ye, Y-H (2017). TRANSCUTANEOUS ELECTRICAL ACUPOINT STIMULATION IMPROVES THE OUTCOMES OF IN VITRO FERTILIZATION: A PROSPECTIVE, RANDOMIZED AND CONTROLLED STUDY. Explore: The Journal of Science & Healing.
The effects of acupuncture on polycystic ovary syndrome: A systematic review and meta-analysis
Qu, F., Yan, W., Hu, X-Y., Barry, J.A., Zhou, J., Wang, F-F., Ye, Y-H., Han, S-P., Li, R., Taw, M.B., Hardiman, P.J. and Robinson, N. (2016). The effects of acupuncture on polycystic ovary syndrome: A systematic review and meta-analysis. European Journal of Integrative Medicine. 8 (1), pp. 12-18.
The role of complementary and alternative medicine (CAM) in sexual and reproductive health
Qidwai, W, Wong, W, Nanji, K and Robinson, N. (2016). The role of complementary and alternative medicine (CAM) in sexual and reproductive health. European Journal of Integrative Medicine. 8 (1), pp. 1-3.
The Importance of Evidence for the Integration of Traditional and Complementary Medicine into Western Healthcare?
Robinson, N. (2016). The Importance of Evidence for the Integration of Traditional and Complementary Medicine into Western Healthcare? World Journal of Traditional Chinese Medicine. 2 (1), pp. 74 - 79.
Harmonising data collection from osteoarthritis studies to enable stratification: Recommendations on core data collection from an Arthritis Research UK clinical studies group
Kingsbury, SR, Corp, N, Watt, FE, Felson, DT, O'Neill, TW, Holt, CA, Jones, RK, Conaghan, PG, Arden, NK, Adams, J, Appleyard, I, Birrell, F, Blank, M, Callaghan, MJ, Cumming, J, Chapman, GJ, Halstead, J, Hamilton, DF, Hurley, M, Martin, K, Mason, DJ, Nuki, G, Redmond, AC, Reilly, K, Robinson, N., Roddy, E, Simpson, H, Smith, TO, Thomas, C, Thomas, E, Wilkinson, J and Wise, E (2016). Harmonising data collection from osteoarthritis studies to enable stratification: Recommendations on core data collection from an Arthritis Research UK clinical studies group. Rheumatology (United Kingdom). 55 (8), pp. 1394-1402.
Introducing “Evidence for clinical practice” [Editorial]
Alper, BS, Malone-Moses, M, Manheimer, EW and Robinson, N. (2016). Introducing “Evidence for clinical practice” [Editorial]. European Journal of Integrative Medicine. 8 (3), pp. 147-149.
Pediatric integrative medicine needs research evidence to guide decision-making
Gardiner, P and Robinson, N. (2016). Pediatric integrative medicine needs research evidence to guide decision-making. European Journal of Integrative Medicine. 8 (2), pp. 79 - 80.
Bromelain and Cardiovascular Risk Factors in Diabetes: An Exploratory Randomized, Placebo Controlled, Double Blind Clinical Trial
Ley, C., NI, Q, Liao, X, Gao, H-L and Robinson, N. (2016). Bromelain and Cardiovascular Risk Factors in Diabetes: An Exploratory Randomized, Placebo Controlled, Double Blind Clinical Trial. Chinese Journal of Integrative Medicine. 22 (10), pp. 728-737.
General Practitioners’ use of and attitudes to acupuncture in relation to the UK’s National Institute for Health and Care Excellence (NICE) clinical guidelines—A pilot study
Czarnawska-Iliev, I and Robinson, N. (2016). General Practitioners’ use of and attitudes to acupuncture in relation to the UK’s National Institute for Health and Care Excellence (NICE) clinical guidelines—A pilot study. European Journal of Integrative Medicine. 8 (4).
Evidence is in the Eye of the Beholder: The case of the 2016 draft NICE Guidelines for Low Back Pain [editorial]
Hopper Koppelman, M, Bovey, M and Robinson, N. (2016). Evidence is in the Eye of the Beholder: The case of the 2016 draft NICE Guidelines for Low Back Pain [editorial]. European Journal of Integrative Medicine. 8 (4).
Common mistakes when using plant names and how to avoid them
Dauncey, EA, Irving, J, Allkin, R and Robinson, N. (2016). Common mistakes when using plant names and how to avoid them. European Journal of Integrative Medicine. 8 (5), pp. 597-601.
Integrating acupuncture: are there positive health outcomes for women?
Robinson, N. (2016). Integrating acupuncture: are there positive health outcomes for women? Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology). 18 (3), pp. 233-238.
Traditional Chinese Medicine - challenges for research
Robinson, N. (2015). Traditional Chinese Medicine - challenges for research. in: McCarthy, P.W. and Langweiler, M. (ed.) Methodologies for Effectively Assessing Complementary and Alternative Medicine (CAM) London Singing Dragon.
Acupuncture for the treatment of phantom limb syndrome in lower limb amputees: a randomised controlled feasibility study
Trevelyan, EG, Turner, WA, Summerfield-Mann, L and Robinson, N. (2015). Acupuncture for the treatment of phantom limb syndrome in lower limb amputees: a randomised controlled feasibility study. Trials.
The politics of integrative medicine: The case of CAM
Saks, M and Robinson, N. (2015). The politics of integrative medicine: The case of CAM. European Journal of Integrative Medicine. 7 (6), pp. 557-560.
A systematic review of experimental and clinical acupuncture in chemotherapy-induced peripheral neuropathy.
Franconi, G, Manni, L, Schröder, S, Marchetti, P and Robinson, N. (2013). A systematic review of experimental and clinical acupuncture in chemotherapy-induced peripheral neuropathy. Evid Based Complement Alternat Med. 2013, p. 516916.