Changing prevalence of wheeze, rhinitis and allergic sensitisation in late childhood: findings from 2 Isle of Wight birth cohorts’ 12-years apart

Journal article


Patil, V., Kurukulaaratchy, R., Venter, C., Grundy, J., Roberts, G., Dean, T. and Arshad, S. H. (2015). Changing prevalence of wheeze, rhinitis and allergic sensitisation in late childhood: findings from 2 Isle of Wight birth cohorts’ 12-years apart. Clinical and Experimental Allergy. 45 (9), pp. 1430-1438. https://doi.org/10.1111/cea.12534
AuthorsPatil, V., Kurukulaaratchy, R., Venter, C., Grundy, J., Roberts, G., Dean, T. and Arshad, S. H.
Abstract

Background: While the prevalence of asthma in children is decreasing or remaining the same, time-trends in the prevalence of rhinitis in children are not known. Understanding sensitisation trends may help inform about trends in asthma and rhinitis prevalence.Objective: To assess time -trends of wheeze, rhinitis and aero-allergen sensitisation prevalence at 10 years of age we compared two birth cohorts established 12 years apart. To gain insight into differences in disease prevalence we assessed association of family-history, early life exposures and sensitisation with wheeze and rhinitis in each cohort.Methods: The IoW (Isle-of-Wight) and FAIR (Food-Allergy-and-Intolerance-Research) unselected birth cohorts were established in 1989 and 2001 in IoW. Identical ISAAC questionnaire and Skin Prick test data were collected and compared at 10 years of age.Results: Over the 12 year period from 2001 to 2012, prevalence of lifetime-wheeze, current-wheeze, and those ever-treated-for-asthma decreased by 15.9% (45.5-vs-29.6,p<0.001), 3.9% (18.9-vs-15, p=0.020) and 8.2% (31.7-vs-23.5, p=0.001) respectively. Conversely, current-rhinitis and lifetime-rhinitis prevalence increased by 5.5% (22.6-vs-28.1, p=0.004) and 13% (18.6-vs-31.7, p<0.001) respectively. Atopic status remained stable, however house dust mite (HDM) sensitisation decreased by 5.6% (19.2-vs-13.6, p=0.004) and grass sensitisation increased by 3.5% (12.9-vs-16.4, p=0.054). Male-sex, parental history of asthma and HDM sensitisation were significantly associated with lifetime-wheeze in both cohorts while maternal smoking during pregnancy was a significant risk factor only in the earlier IoW-cohort. Parental history of rhinitis and grass sensitisation were significantly associated with lifetime-rhinitis in both cohorts while HDM sensitisation was significant only for the IoW-cohort.Conclusion: Contrasting changes were noted with falling wheeze and HDM sensitisation but rising rhinitis and grass sensitisation prevalence. Changing prevalence of aero-allergen sensitisations may explain the different time trends observed in these cohorts.

Year2015
JournalClinical and Experimental Allergy
Journal citation45 (9), pp. 1430-1438
PublisherWiley
Digital Object Identifier (DOI)https://doi.org/10.1111/cea.12534
Publication dates
Print24 Aug 2015
Publication process dates
Accepted17 Feb 2015
Deposited12 Aug 2021
Accepted author manuscript
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Open
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This is the peer reviewed version of the following article: Patil, V. K., Kurukulaaratchy, R. J., Venter, C., Grundy, J., Roberts, G., Dean, T. and Arshad, S. H. (2015), Changing prevalence of wheeze, rhinitis and allergic sensitisation in late childhood: findings from 2 Isle of Wight birth cohorts’ 12-years apart. Clin Exp Allergy. Accepted Author Manuscript. doi:10.1111/cea.12534, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/cea.12534/full. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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