Prevalence and cumulative incidence of food hyper-sensitivity in the first 10 years of life
Journal article
Venter, C., Patil, V., Grundy, J., Glasbey, G., Twiselton, R., Arshad, S. H. and Dean, T. (2016). Prevalence and cumulative incidence of food hyper-sensitivity in the first 10 years of life. Pediatric Allergy and Immunology. 27 (5), pp. 452-458. https://doi.org/10.1111/pai.12564
Authors | Venter, C., Patil, V., Grundy, J., Glasbey, G., Twiselton, R., Arshad, S. H. and Dean, T. |
---|---|
Abstract | Background - Prevalence, incidence and natural history of food hypersensitivity (FHS) and its trends in an unselected cohort of older children are unclear.Methods - A birth cohort born on the Isle of Wight (UK) between 2001 and 2002 was followed up prospectively. Children were clinically examined and skin prick tested at set times and invited for food challenges when indicated. At 10 years of age, children were also invited for a blood test.Results - A total of 969 children were recruited at 12 weeks of pregnancy, and 92.9%, 88.5%, 91.6% and 85.3% were assessed at 1, 2, 3 and 10 years. Prevalence of sensitization to any allergen over 10 years was 186 of 969 (19.2%; 95% CI: 16.84–21.8) and 108 of 969 (11.2%; 95% CI: 9.31–13.29) children were sensitized to at least one predefined food allergen. Excluding wheat (due to cross-reactivity with pollen), 40 of 969 (4.1%; 95% CI: 3.19–5.32) children were sensitized to a predefined food allergen. Using food challenges and/or a good clinical history, the cumulative incidence of food hypersensitivity (FHS) in the first decade of life was 64 of 947 (6.8%, 95% CI: 5.2–8.4), while the prevalence of FHS at 10 years was 30 of 827 (3.6%, 95% CI: 2.54–5.15). The vast majority, 25 of 827 (3.0%, 95% CI: 1.8–4.2), suffered from IgE-mediated food allergy, while 5 of 827 (0.6%, 95% CI: 0.07–1.3) had non-IgE-mediated food allergy/food intolerance.Conclusions - By the age of 10 years, 6.8% of children suffered from FHS based on food challenges and a good clinical history. There was a large discrepancy between reported and diagnosed FHS. |
Year | 2016 |
Journal | Pediatric Allergy and Immunology |
Journal citation | 27 (5), pp. 452-458 |
Publisher | Wiley |
Digital Object Identifier (DOI) | https://doi.org/10.1111/pai.12564 |
Publication dates | |
Online | 06 May 2016 |
13 Jul 2016 | |
Publication process dates | |
Accepted | 16 Mar 2016 |
Deposited | 11 Aug 2021 |
Accepted author manuscript | License File Access Level Open |
Additional information | This is the peer reviewed version of the following article: Venter C, Patil V, Grundy J, Glasbey G, Twiselton R, Arshad SH, Dean T. Prevalence and cumulative incidence of food hyper-sensitivity in the first 10 years of life. Pediatr Allergy Immunol 2016: 27: 452–458, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/pai.12564/full. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
https://openresearch.lsbu.ac.uk/item/8x8vx
Download files
Accepted author manuscript
Prevalence and cumulative incidence of food hyper-sensitivity in the first 10 years of life.pdf | ||
License: CC BY-NC 4.0 | ||
File access level: Open |
67
total views229
total downloads4
views this month3
downloads this month