The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart

Journal article

Venter, C., Maslin, K., Patil, V., Kurukulaaratchy, R., Grundy, J., Glasbey, G., Twiselton, R., Dean, T. and Arshad, S. H. (2016). The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart. Pediatric Allergy and Immunology. 27 (2), pp. 804-811. https://doi.org/10.1111/pai.12616
AuthorsVenter, C., Maslin, K., Patil, V., Kurukulaaratchy, R., Grundy, J., Glasbey, G., Twiselton, R., Dean, T. and Arshad, S. H.
Abstract

The aim of this study was to explore the natural history of peanut allergy in childhood in two birth cohorts from the same geographical region in the South of England.MethodsThe FAIR birth cohort was established on the Isle of Wight (UK) between 2001-2002 (n = 969). Children were followed up prospectively, skin prick tested (SPT) to peanut allergens at 1, 2, 3 and 10 years and food challenges performed. The Isle of Wight (IOW) Birth cohort was established in 1989 (n = 1456). SPTs were performed at 1, 2, 4 and 10 years. Peanut allergy was based on positive SPT and a good clinical history.ResultsIn the FAIR cohort, the prevalence of sensitization to peanut was 0.4%, 2.0%, 2.0% and 2.4% at 1,2,3 and 10 years respectively. At 10 years of age, 12/828 (1.5%) children were diagnosed with peanut allergy. One child (8%) outgrew her peanut allergy between 3 and 10 years and two children (15%) presented with new onset peanut allergy. Over the first ten years of life, 13/934 (1.4%) children were diagnosed with peanut allergy. In the IOW cohort, 6/1034 (0.58%) were diagnosed with peanut allergy at 10 years. We found no significant differences between the FAIR and the IOW birth cohort for any of the time points studied.ConclusionPeanut allergy appears to be stable over the first ten years of life in our cohorts. There was no significant difference in peanut sensitization or clinical peanut allergy between 1989 and 2001.

Year2016
JournalPediatric Allergy and Immunology
Journal citation27 (2), pp. 804-811
PublisherWiley
Digital Object Identifier (DOI)https://doi.org/10.1111/pai.12616
Publication dates
Online16 Sep 2016
Print08 Dec 2016
Publication process dates
Accepted16 Jul 2016
Deposited11 Aug 2021
Accepted author manuscript
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Open
Additional information

This is the pre-peer reviewed version of the following article: Venter, C., Maslin, K., Patil, V., Kurukulaaratchy, R., Grundy, J., Glasbey, G., Twiselton, R., Dean, T. and Arshad, S. H. (2016), The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart. Pediatr Allergy Immunol. Accepted Author Manuscript. doi:10.1111/pai.12616, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/pai.12616/full. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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