The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart

Journal article

Venter, C., Maslin, K., Patil, V., Kurukulaaratchy, R., Grundy, J., Glasbey, G., Twiselton, R., Dean, T. and Arshad, S. H. (2016). The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart. Pediatric Allergy and Immunology. 27 (2), pp. 804-811. https://doi.org/10.1111/pai.12616
AuthorsVenter, C., Maslin, K., Patil, V., Kurukulaaratchy, R., Grundy, J., Glasbey, G., Twiselton, R., Dean, T. and Arshad, S. H.
Abstract

The aim of this study was to explore the natural history of peanut allergy in childhood in two birth cohorts from the same geographical region in the South of England.MethodsThe FAIR birth cohort was established on the Isle of Wight (UK) between 2001-2002 (n = 969). Children were followed up prospectively, skin prick tested (SPT) to peanut allergens at 1, 2, 3 and 10 years and food challenges performed. The Isle of Wight (IOW) Birth cohort was established in 1989 (n = 1456). SPTs were performed at 1, 2, 4 and 10 years. Peanut allergy was based on positive SPT and a good clinical history.ResultsIn the FAIR cohort, the prevalence of sensitization to peanut was 0.4%, 2.0%, 2.0% and 2.4% at 1,2,3 and 10 years respectively. At 10 years of age, 12/828 (1.5%) children were diagnosed with peanut allergy. One child (8%) outgrew her peanut allergy between 3 and 10 years and two children (15%) presented with new onset peanut allergy. Over the first ten years of life, 13/934 (1.4%) children were diagnosed with peanut allergy. In the IOW cohort, 6/1034 (0.58%) were diagnosed with peanut allergy at 10 years. We found no significant differences between the FAIR and the IOW birth cohort for any of the time points studied.ConclusionPeanut allergy appears to be stable over the first ten years of life in our cohorts. There was no significant difference in peanut sensitization or clinical peanut allergy between 1989 and 2001.

Year2016
JournalPediatric Allergy and Immunology
Journal citation27 (2), pp. 804-811
PublisherWiley
Digital Object Identifier (DOI)https://doi.org/10.1111/pai.12616
Publication dates
Online16 Sep 2016
Print08 Dec 2016
Publication process dates
Accepted16 Jul 2016
Deposited11 Aug 2021
Accepted author manuscript
License
File Access Level
Open
Additional information

This is the pre-peer reviewed version of the following article: Venter, C., Maslin, K., Patil, V., Kurukulaaratchy, R., Grundy, J., Glasbey, G., Twiselton, R., Dean, T. and Arshad, S. H. (2016), The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart. Pediatr Allergy Immunol. Accepted Author Manuscript. doi:10.1111/pai.12616, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/pai.12616/full. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Permalink -

https://openresearch.lsbu.ac.uk/item/8x8w2

Download files

Accepted author manuscript
The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart.pdf
License: CC BY-NC 4.0
File access level: Open

  • 83
    total views
  • 205
    total downloads
  • 3
    views this month
  • 1
    downloads this month

Export as

Related outputs

Dietary diversity during infancy and the association with childhood food allergen sensitization
Maslin, K., Pickett, K., Ngo, S., Anderson, W., Dean, T. and Venter, C. (2021). Dietary diversity during infancy and the association with childhood food allergen sensitization. Pediatric Allergy and Immunology. https://doi.org/10.1111/pai.13650
Different Measures of Diet Diversity During Infancy and the Association with Childhood Food Allergy in a UK Birth Cohort Study
Venter, C., Maslin, K., Holloway, J.W., Silveira, L.J., Fleischer, D.M., Dean, T. and Arshad, S.H. (2020). Different Measures of Diet Diversity During Infancy and the Association with Childhood Food Allergy in a UK Birth Cohort Study. The Journal of Allergy and Clinical Immunology: In Practice. 8 (6), pp. 2017-2026. https://doi.org/10.1016/j.jaip.2020.01.029
Temporal change in maternal dietary intake during pregnancy and lactation between and within 2 pregnancy cohorts assembled in the United Kingdom
Maslin, K., Venter, C., Palumbo, M., Glueck, D., Mitchell, F., Potter, S., Grundy, J., Glasbey, G., Dean, T. and Arshad, S. H (2019). Temporal change in maternal dietary intake during pregnancy and lactation between and within 2 pregnancy cohorts assembled in the United Kingdom. The Journal of Allergy and Clinical Immunology: In Practice. 8 (3), pp. 1088-1090. https://doi.org/10.1016/j.jaip.2019.11.041
The views of children and young people on the use of silk garments for the treatment of eczema: a nested qualitative study within the CLOTHing for the relief of Eczema Symptoms (CLOTHES) randomized controlled trial
Wake, E.V., Batchelor, J., Lawton, S., Thomas, K.S., Harrison, E.F., Cowdell, F.C. and Dean, T. (2018). The views of children and young people on the use of silk garments for the treatment of eczema: a nested qualitative study within the CLOTHing for the relief of Eczema Symptoms (CLOTHES) randomized controlled trial. British Journal of Dermatology. 178 (1), pp. 183-190. https://doi.org/10.1111/bjd.15909
ω-3 LCPUFA supplementation during pregnancy and risk of allergic outcomes or sensitization in offspring: A systematic review and meta-analysis
Vahdaninia, M., Mackenzie, H., Dean, T. and Helps, S. (2018). ω-3 LCPUFA supplementation during pregnancy and risk of allergic outcomes or sensitization in offspring: A systematic review and meta-analysis. Annals of Allergy, Asthma and Immunology. 122 (3), pp. 302-313. https://doi.org/10.1016/j.anai.2018.12.008
Use of cluster analysis to characterize patterns of sensitization in childhood allergy
Venter, C., Maslin, K., Zhang, H., Kaushal, A., Terry, W., Patil, V., Dean, T. and Arshad, S. H. (2018). Use of cluster analysis to characterize patterns of sensitization in childhood allergy. Pediatric Allergy and Immunology. 29 (6), pp. 644-648. https://doi.org/10.1111/pai.12925
The effectiveness of ω-3 polyunsaturated fatty acid interventions during pregnancy on obesity measures in the offspring: an up-to-date systematic review and meta-analysis
Vahdaninia, M., Mackenziem H., Dean, T. and Helps, S. (2018). The effectiveness of ω-3 polyunsaturated fatty acid interventions during pregnancy on obesity measures in the offspring: an up-to-date systematic review and meta-analysis. European Journal of Nutrition. 58, pp. 2597-2613. https://doi.org/10.1007/s00394-018-1824-9
Use of baked milk challenges and milk ladders in clinical practice: a worldwide survey of healthcare professionals
Athanasopoulou, P., Deligianni, E., Dean, T., Dewey, A. and Venter, C. (2017). Use of baked milk challenges and milk ladders in clinical practice: a worldwide survey of healthcare professionals. Clinical and Experimental Allergy. 47 (3), pp. 430-434. https://doi.org/10.1111/cea.12890
Silk garments plus standard care compared with standard care for treating eczema in children: a randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial)
Thomas, K. S., Bradshaw, L. E., Sach, T. H., Batchelor, J. M., Lawton, S., Harrison, E., Haines, R. H., Ahmed, A., Williams, H. C., Dean, T., Burrows, N. P., Pollock, I., Llewellyn, J., Crang, C., Grundy, J. D., Guiness, J., Gribbin, A., Mitchell, E. J., Cowdell, F., Brown, S. J. and Montgomery, A. (2017). Silk garments plus standard care compared with standard care for treating eczema in children: a randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial). Plos Medicine. 14 (4), p. e1002280. https://doi.org/10.1371/journal.pmed.1002280
Randomised controlled trial of silk therapeutic garments for the management of atopic eczema in children: the CLOTHES trial
Thomas, K. S., Bradshaw, L. E., Sach, T. H., Cowdell, F., Batchelor, J. M., Lawton, S., Harrison, E., Haines, R. H., Ahmed, A., Dean, T., Burrows, N. P., Pollock, I., Buckley, H., Williams, H. C., Llewellyn, J., Crang, C., Grundy, J. D., Guiness, J., Gribbin, A., Wake, E. V., Mitchell, E.J., Brown, S.J. and Montgomery, A.A. (2017). Randomised controlled trial of silk therapeutic garments for the management of atopic eczema in children: the CLOTHES trial. Health Technology Assessment. 21 (16), pp. 1-260. https://doi.org/10.3310/hta21160
Natural menopause among women below 50 years in India: a population based study
Pallikadavath, S., Ogollah, R., Singh, A., Dean, T., Dewey, A. and Stones, W. (2017). Natural menopause among women below 50 years in India: a population based study. Indian Journal of Medical Research. 144 (3), pp. 366-377. https://doi.org/10.4103/0971-5916.198676
Comparison of nutrient intake in adolescents and adults with and without food allergies
Maslin, K., Venter, C., Mackenzie, H., Vlieg-Boerstra, B., Dean, T. and Sommer, I. (2017). Comparison of nutrient intake in adolescents and adults with and without food allergies. Journal of Human Nutrition and Dietetics. 31 (2), pp. 209-217. https://doi.org/10.1111/jhn.12495
Very low prevalence of IgE mediated wheat allergy and high levels of cross-sensitisation between grass and wheat in a UK birth cohort
Venter, C., Maslin, K., Arshad, S. H., Patil, V., Grundy, J., Glasbey, G., Twiselton, R. and Dean, T. (2016). Very low prevalence of IgE mediated wheat allergy and high levels of cross-sensitisation between grass and wheat in a UK birth cohort. Clinical and Translational Allergy. 6 (1). https://doi.org/10.1186/s13601-016-0111-1
The accuracy of dietary recall of infant feeding and food allergen data
van Zyl, Z., Maslin, K., Dean, T., Blauuw, R. and Venter, C. (2016). The accuracy of dietary recall of infant feeding and food allergen data. Journal of Human Nutrition and Dietetics. 29 (6), pp. 777-785. https://doi.org/10.1111/jhn.12384
Temperature-controlled laminar airflow in severe asthma for exacerbation reduction (The LASER Trial): study protocol for a randomised controlled trial
Storrar, W., Fogg, C., Brown, T., Dennison, P., Yu, L-M., Dewey, A., Luengo-Fernandez, R., Dean, T., Rahman, N., Mansur, A., Howarth, P. H., Bradding, P. and Chauhan, A. J. (2016). Temperature-controlled laminar airflow in severe asthma for exacerbation reduction (The LASER Trial): study protocol for a randomised controlled trial. Trials. 17, p. 15. https://doi.org/10.1186/s13063-015-1134-y
Taste preference, food neophobia and nutritional intake in children consuming a cows’ milk exclusion diet: a prospective study
Maslin, K., Grimshaw, K., Oliver, E., Roberts, G., Arshad, S. H., Dean, T., Grundy, J., Glasbey, G. and Venter, C. (2016). Taste preference, food neophobia and nutritional intake in children consuming a cows’ milk exclusion diet: a prospective study. Journal of Human Nutrition and Dietetics. 29 (6), pp. 786-796. https://doi.org/10.1111/jhn.12387
Prevalence and cumulative incidence of food hyper-sensitivity in the first 10 years of life
Venter, C., Patil, V., Grundy, J., Glasbey, G., Twiselton, R., Arshad, S. H. and Dean, T. (2016). Prevalence and cumulative incidence of food hyper-sensitivity in the first 10 years of life. Pediatric Allergy and Immunology. 27 (5), pp. 452-458. https://doi.org/10.1111/pai.12564
Prenatal intake of vitamins and allergic outcomes in the offspring: a systematic review and meta-analysis
Vahdaninia, M., MacKenzie, H., Helps, S. and Dean, T. (2016). Prenatal intake of vitamins and allergic outcomes in the offspring: a systematic review and meta-analysis. The Journal of Allergy and Clinical Immunology: In Practice. 5 (3), pp. 771-778. https://doi.org/10.1016/j.jaip.2016.09.024
Does concurrent breastfeeding alongside the introduction of solid food prevent the development of food allergy?
Venter, C., Maslin, K., Dean, T. and Arshad, S.H. (2016). Does concurrent breastfeeding alongside the introduction of solid food prevent the development of food allergy? 5, p. e40. https://doi.org/10.1017/jns.2016.31
Dietary variety and food group consumption in children consuming a cows’ milk exclusion diet
Maslin, K., Dean, T., Arshad, S.H. and Venter, C. (2016). Dietary variety and food group consumption in children consuming a cows’ milk exclusion diet. Pediatric Allergy and Immunology. 27, pp. 471-477. https://doi.org/10.1111/pai.12573
Cows’ milk exclusion diet during infancy: is there a long term effect on children's eating behaviour and food preferences?
Maslin, K., Grundy, J. D., Glasbey, G., Dean, T., Arshad, S. H., Grimshaw, K., Oliver, E., Roberts, G. and Venter, C. (2016). Cows’ milk exclusion diet during infancy: is there a long term effect on children's eating behaviour and food preferences? Pediatric Allergy and Immunology. 27 (2), pp. 141-146. https://doi.org/10.1111/pai.12513
Validation and acceptability of double-blind, placebo-controlled food challenges in children
Venter, C., Maslin, K., Patil, V., Grundy, J., Glasbey, G., Raza, A., Vlieg-Boerstra, B. and Dean, T. (2015). Validation and acceptability of double-blind, placebo-controlled food challenges in children. Pediatric Allergy and Immunology. 27 (1), pp. 92-93. https://doi.org/10.1111/pai.12454
Relationship between maternal and child behaviors in pediatric food allergy: an exploratory study
Sommer, I., Chisholm, V., MacKenzie, H., Venter, C. and Dean, T. (2015). Relationship between maternal and child behaviors in pediatric food allergy: an exploratory study. Annals of Allergy, Asthma and Immunology. 116 (1), pp. 78-80. https://doi.org/10.1016/j.anai.2015.10.006
Randomised controlled trial of fish oil supplement to treat cancer cachexia
Dewey, A., Higgins, B., Baughan, c., Stores, R., Dean, T. and Kilburn, S. (2015). Randomised controlled trial of fish oil supplement to treat cancer cachexia. BAOJ Palliative Medicine. 1 (1), pp. 1-8.
Health-related quality of life in children with perceived and diagnosed food hypersensitivity
Venter, C., Sommer, I., Moonesinghe, H., Grundy, J. D., Glasbey, G., Patil, V. and Dean, T. (2015). Health-related quality of life in children with perceived and diagnosed food hypersensitivity. Pediatric Allergy and Immunology. 26 (2), pp. 126-132. https://doi.org/10.1111/pai.12337
Fussy eating and feeding difficulties in infants and toddlers consuming a cows’ milk exclusion diet
Maslin, K., Dean, T., Arshad, S.H. and Venter, C. (2015). Fussy eating and feeding difficulties in infants and toddlers consuming a cows’ milk exclusion diet. Pediatric Allergy and Immunology. 26 (6), pp. 503-508. https://doi.org/10.1111/pai.12427
Changing prevalence of wheeze, rhinitis and allergic sensitisation in late childhood: findings from 2 Isle of Wight birth cohorts’ 12-years apart
Patil, V., Kurukulaaratchy, R., Venter, C., Grundy, J., Roberts, G., Dean, T. and Arshad, S. H. (2015). Changing prevalence of wheeze, rhinitis and allergic sensitisation in late childhood: findings from 2 Isle of Wight birth cohorts’ 12-years apart. Clinical and Experimental Allergy. 45 (9), pp. 1430-1438. https://doi.org/10.1111/cea.12534
Association between healthy eating in pregnancy and allergic status of the offspring in childhood
Moonesinghe, H., Patil, V., Dean, T., Arshad, S. H., Glasbey, G., Grundy, J. D. and Venter, C. (2015). Association between healthy eating in pregnancy and allergic status of the offspring in childhood. Annals of Allergy, Asthma and Immunology. 116 (2), pp. 163-165. https://doi.org/10.1016/j.anai.2015.11.005
A qualitative study of mothers’ perceptions of weaning and the use of commercial infant food in the United Kingdom
Maslin, K., Galvin, A.D., Shepherd, S., Dean, T., Dewey. A. and Venter, C. (2015). A qualitative study of mothers’ perceptions of weaning and the use of commercial infant food in the United Kingdom. Maternal and Paediatric Nutrition Journal. 1 (1). https://doi.org/10.4172/2472-1182.1000103
A multi-centre, parallel group superiority trial of silk therapeutic clothing compared to standard care for the management of eczema in children (CLOTHES Trial): study protocol for a randomised controlled trial
Harrison, E., Haines, R. H., Cowell, F., Sach, T. H., Dean, T., Pollock, I., Burrows, N. P., Buckley, H., Batchelor, J. M., Williams, H. C., Lawton, S., Brown, S. J., Bradshaw, L. E., Ahmed, A., Montgomery, A. A., Mitchell, E. J. and Thomas, K. S. (2015). A multi-centre, parallel group superiority trial of silk therapeutic clothing compared to standard care for the management of eczema in children (CLOTHES Trial): study protocol for a randomised controlled trial. Trials. 16 (360). https://doi.org/10.1186/s13063-015-0921-9
The natural history of peanut sensitization and allergy in a birth cohort
Arshad, S. H., Venter, C., Roberts, G., Dean, T. and Kurukulaaratchy, R. (2014). The natural history of peanut sensitization and allergy in a birth cohort. The Journal of Allergy and Clinical Immunology: In Practice. 134 (6), pp. 1462-1463. https://doi.org/10.1016/j.jaci.2014.09.026
Information and support from dietary consultation for mothers of children with food allergies
MacKenzie, H, Grundy, J.D., Glasbey, G., Dean, T. and Venter, C. (2014). Information and support from dietary consultation for mothers of children with food allergies. Annals of Allergy, Asthma and Immunology. 114 (1), pp. 23-29. https://doi.org/10.1016/j.anai.2014.10.001
An exploratory investigation of food choice behavior of teenagers with and without food allergies
Sommer, I., MacKenzie, H., Venter, C. and Dean, T. (2014). An exploratory investigation of food choice behavior of teenagers with and without food allergies. Annals of Allergy, Asthma and Immunology. 112 (5), pp. 446-452. https://doi.org/10.1016/j.anai.2014.02.009
What is the impact of contraceptive methods and mixes of contraceptive methods on contraceptive prevalence, unmet need for family planning, and unwanted and unintended pregnancies?
MacKenzie, H., Drahota, A., , Pallikadavath, S., Stones, W., Dean, T., Fogg, C., Stores, R., Kilburn, S., Dewey, A. and Ogollah, R. (2013). What is the impact of contraceptive methods and mixes of contraceptive methods on contraceptive prevalence, unmet need for family planning, and unwanted and unintended pregnancies? Institute of Education, University of London EPPI Centre, Social Science Research Unit.
Pilot cluster randomised controlled trial of flooring to reduce injuries from falls in wards for older people
Drahota, A., Ward, D., Udell, J. E., Soilemezi, D., Ogollah, R., Higgins, B., Dean, T. and Severs, M. (2013). Pilot cluster randomised controlled trial of flooring to reduce injuries from falls in wards for older people. Ageing and Society. 42 (5), pp. 633-640. https://doi.org/10.1093/ageing/aft067
Literature searches and reviews related to the prevalence of food allergy in Europe
Dean, T., MacKenzie, H., Kilburn, S., Moonesinghe, H., Lee, K., Maslin, K. and Venter, C. (2013). Literature searches and reviews related to the prevalence of food allergy in Europe. European Food Safety Authority.
Human resource inequalities at the base of India's public health care system
Pallikadavath, S., Singh, A., Ogollah, R., Dean, T. and Stones, W. (2013). Human resource inequalities at the base of India's public health care system. Health and Place. 23, pp. 26-32. https://doi.org/10.1016/j.healthplace.2013.05.003
Sensory environment on health-related outcomes of hospital patients
Drahota, A., Ward, D., MacKenzie, H., Stores, R., Higgins, B., Gal, D. and Dean, T. (2012). Sensory environment on health-related outcomes of hospital patients. Cochrane Library. 3. https://doi.org/10.1002/14651858.CD005315.pub2
Food allergies and intolerances in children
MacKenzie, H. and Dean, T. (2011). Food allergies and intolerances in children. in: Kilvast, D. and Angus, F. (ed.) Developing children's food products Cambridge Woodhead Publishing. pp. 82-97
A randomised controlled trial of ion-exchange water softeners for the treatment of eczema in children
Thomas, K. S., Dean, T., O'Leary, C. D., Sach, T. H., Koller, K., Frost, A. and Williams, H. C. (2011). A randomised controlled trial of ion-exchange water softeners for the treatment of eczema in children. Plos Medicine. https://doi.org/10.1371/journal.pmed.1000395
A multicentre randomised controlled trial and economic evaluation of ion-exchange water softeners for the treatment of eczema in children: the Softened Water Eczema Trial (SWET)
Thomas, K. S., Koller, K., Dean, T., O’Leary, C. J., Sach, T. H., Frost, A., Pallett, I., Crook, A. M., Meredith, S. and Nunn, A. J. (2011). A multicentre randomised controlled trial and economic evaluation of ion-exchange water softeners for the treatment of eczema in children: the Softened Water Eczema Trial (SWET). Health Technology Assessment. 15 (8). https://doi.org/10.3310/hta15080
Care home versus hospital and own home environments for rehabilitation of older people
Drahota, A., Ward, D., Gal, D., Severs, M. and Dean, T. (2008). Care home versus hospital and own home environments for rehabilitation of older people. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD003164.pub2
Randomized, double-blind comparison of patient-controlled epidural infusion vs nurse-administered epidural infusion for postoperative analgesia in patients undergoing colonic resection
Nightingale, J.J., Knight, M.V., Higgins, B. and Dean, T. (2007). Randomized, double-blind comparison of patient-controlled epidural infusion vs nurse-administered epidural infusion for postoperative analgesia in patients undergoing colonic resection. British Journal of Anaesthesia. 98 (3), pp. 380-384. https://doi.org/10.1093/bja/ael367
The effects of a double blind, placebo controlled, artificial food colourings and benzoate preservative challenge on hyperactivity in a general population sample of preschool children
Bateman, B., Warner, J. O., Hutchinson, E., Dean, T., Rowlandson, P., Gant, C., Grundy, J., Fitzgerald, C. and Stevenson, J. (2004). The effects of a double blind, placebo controlled, artificial food colourings and benzoate preservative challenge on hyperactivity in a general population sample of preschool children. Archives of Disease in Childhood. 89, pp. 506-511. https://doi.org/10.1136/adc.2003.031435