UBE2S is associated with malignant characteristics of breast cancer cells

Journal article

Ayesha, A K, Hyodo, T, Asano, E, Sato, N, Mansour, M A, Ito, S, Hamaguchi, M and Senga, T (2016). UBE2S is associated with malignant characteristics of breast cancer cells. Tumor Biology. 37 (1), pp. 763-772. https://doi.org/10.1007/s13277-015-3863-7
AuthorsAyesha, A K, Hyodo, T, Asano, E, Sato, N, Mansour, M A, Ito, S, Hamaguchi, M and Senga, T
Abstract

Ubiquitination is essential for various biological processes, such as signal transduction, intracellular traffick-ing, and protein degradation. Accumulating evidence has demonstrated that ubiquitination plays a crucial role in cancer development. In this report, we examine the expression and function of ubiquitin-conjugating enzyme E2S (UBE2S) in breast cancer. Immunohistochemical analysis revealed that UBE2S is highly expressed in breast cancer. The depletion of UBE2S by siRNA induced disruption of the actin cytoskel-eton and focal adhesions. Interestingly, phosphorylation of FAK at Tyr397, which is important for the transduction of integrin-mediated signaling, was significantly reduced by UBE2S knockdown. We also show that UBE2S knockdown suppressed the malignant characteristics of breast cancer cells, such as migration, invasion, and anchorage-independent growth. Our results indicate that UBE2S could be a potential target for breast cancer treatment.

Year2016
JournalTumor Biology
Journal citation37 (1), pp. 763-772
PublisherSpringer
ISSN1423-0380
Digital Object Identifier (DOI)https://doi.org/10.1007/s13277-015-3863-7
Publication dates
Print06 Aug 2015
Publication process dates
Accepted29 Jul 2015
Deposited10 Aug 2020
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