FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression
Journal article
Akter, K.A., Mansour, M.A., Hyodo, T. and Senga, T. (2017). FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression. The international journal of biochemistry & cell biology. 84, pp. 1-13. https://doi.org/10.1016/j.biocel.2016.12.013
| Authors | Akter, K.A., Mansour, M.A., Hyodo, T. and Senga, T. |
|---|---|
| Abstract | Protein Arginine Methyl Transferase 1 (PRMT1) is deemed to be a potential oncogenic protein considering its overexpression in several malignancies including colorectal cancer. However, the molecular pathogenesis regarding PRMT1 overexpression and overall poor patient survival involved in this devastating and life threatening cancer remains obscured. In our previous study, we have identified FAM98A as a novel substrate of PRMT1 and also identified its role in ovarian cancer progression. Here, we showed that the two structural homologs FAM98A and FAM98B included in a novel complex with DDX1 and C14orf166 are required for PRMT1 expression. Analysis of the data from The Cancer Genome Atlas (TCGA) database and clinical colorectal cancer specimens also demonstrated a strong positive correlation and co-occurrence of PRMT1, FAM98A and FAM98B. These findings provide a mechanistic insight into how knockdown of FAM98A or FAM98B can suppress the malignant characteristics of cancer cells. Besides, we showed that FAM98A and FAM98B are working in the same axis as knockdown of both proteins together does not cause additional reduction in the cellular proliferation and colony formation of colorectal cancer cells. |
| Year | 2017 |
| Journal | The international journal of biochemistry & cell biology |
| Journal citation | 84, pp. 1-13 |
| Publisher | Pergamon |
| Digital Object Identifier (DOI) | https://doi.org/10.1016/j.biocel.2016.12.013 |
| Publication dates | |
| 28 Dec 2016 | |
| Publication process dates | |
| Accepted | 25 Dec 2016 |
| Deposited | 10 Aug 2020 |
| Accepted author manuscript | License File Access Level Open |
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| FAM98A associates_MANSOUR.pdf | ||
| License: CC BY-NC-ND 4.0 | ||
| File access level: Open | ||
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