TRIP13 is expressed in colorectal cancer and promotes cancer cell invasion

Journal article


Kurita, K, Maeda, M, Mansour, MA, Kokuryo, T, Uehara, K, Yokoyama, Y, Nagino, M, Hamaguchi, M and Senga, T (2016). TRIP13 is expressed in colorectal cancer and promotes cancer cell invasion. Oncology letters. 12, pp. 5240-5246. https://doi.org/10.3892/ol.2016.5332
AuthorsKurita, K, Maeda, M, Mansour, MA, Kokuryo, T, Uehara, K, Yokoyama, Y, Nagino, M, Hamaguchi, M and Senga, T
Abstract

Thyroid hormone receptor interactor 13 (TRIP13)
is a member of the ATPases associated with various cellular
activities family of proteins and is highly conserved in a
wide range of species. Recent studies have demonstrated
that TRIP13 is critical for the inactivation of the spindle
assembly checkpoint and is associated with the progression of certain cancers. In the present study, the role of
TRIP13 in colorectal cancer (CRC) was examined. Reverse
transcription-quantitative polymerase chain reaction analysis
revealed that TRIP13 messenger RNA was highly expressed
in multiple CRC tissues. The depletion of TRIP13 in CRC
cells suppressed cell proliferation, migration and invasion.
To determine whether the catalytic activity of TRIP13 was
critical for cancer progression, an inactive mutant of TRIP13
was expressed in CRC cells. The invasion of cancer cells
that expressed the mutant TRIP13 was signifcantly reduced
compared with that of the wild type TRIP13-expressing
cancer cells. These results indicate that TRIP13 could be a
potential target for CRC treatment.

Keywords TRIP13; invasion; migration; AAA+; colorectal cancer
Year2016
JournalOncology letters
Journal citation12, pp. 5240-5246
PublisherSpandidos Publications
ISSN1792-1074
Digital Object Identifier (DOI)https://doi.org/10.3892/ol.2016.5332
Publication dates
Print01 Nov 2016
Publication process dates
Accepted19 Aug 2016
Deposited04 Aug 2020
Publisher's version
License
File Access Level
Open
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