Aerobic oxidations in flow: opportunities for the fine chemicals and pharmaceuticals industries

Journal article

Gavriilidis, A., Constantinou, A, Hellgardt, K., Hii, K.K.(M), Hutchings, G.J., Brett, G.L., Kuhn, S. and Marsden, S.P. (2016). Aerobic oxidations in flow: opportunities for the fine chemicals and pharmaceuticals industries. Reaction Chemistry and Engineering. 1, pp. 595-612. https://doi.org/10.1039/c6re00155f
AuthorsGavriilidis, A., Constantinou, A, Hellgardt, K., Hii, K.K.(M), Hutchings, G.J., Brett, G.L., Kuhn, S. and Marsden, S.P.
Abstract

Molecular oxygen is without doubt the greenest oxidant for redox reactions, yet aerobic oxidation is one of the most challenging to perform with good chemoselectivity, particularly on an industrial scale. This collaborative review (between teams of chemists and chemical engineers) describes the current scientific and operational hurdles that prevent the utilisation of aerobic oxidation reactions for the production of speciality chemicals and active pharmaceutical ingredients (APIs). The safety aspects of these reactions are discussed, followed by an overview of (continuous flow) reactors suitable for aerobic oxidation reactions that can be applied on scale. Some examples of how these reactions are currently performed in the industrial laboratory (in batch and in flow) are presented, with particular focus on the scale-up strategy. Last but not least, further challenges and future perspectives are presented in the concluding remarks.

Year2016
JournalReaction Chemistry and Engineering
Journal citation1, pp. 595-612
PublisherRoyal Society of Chemistry (RSC)
Digital Object Identifier (DOI)https://doi.org/10.1039/c6re00155f
Publication dates
Print22 Sep 2016
Publication process dates
Deposited28 Mar 2017
Accepted13 Sep 2016
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