Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019

Journal article

Paulson, K.R., Kamath, A.M., Alam, T., Bienhoff, K., Abady, G.G., Abbas, J., Abbasi-Kangevari, M., Abbastabar, H., Abd-Allah, F., Abd-Elsalam, S.M., Abdoli, A., Abedi, A., Abolhassani, H., Abreu, L.G., Abu-Gharbieh, E., Abu-Rmeileh, N.M., Abushouk, A.I., Adamu, A.L., Adebayo, O.M., Adegbosin, A.E., Adekanmbi, V., Adetokunboh, O.O., Adeyinka, D.A., Adsuar, J.C., Afshari, K., Aghaali, M., Agudelo-Botero, M., Ahinkorah, B.O., Ahmad, T., Ahmadi, K., Ahmed, M.B., Aji, B., Akalu, Y., Akinyemi, O.O., Aklilu, A., Al-Aly, Z., Alam, K., Alanezi, F.M., Alanzi, T.M., Alcalde-Rabanal, J.E., Al-Eyadhy, A., Ali, T., Alicandro, G., Alif, S.M., Alipour, V., Alizade, H., Aljunid, S.M., Almasi-Hashiani, A., Almasri, N.A., Al-Mekhlafi, H.M., Alonso, J., Al-Raddadi, R.M., Altirkawi, K.A., Alumran, A.K., Alvis-Guzman, N., Alvis-Zakzuk, N.J., Ameyaw, E.K., Amini, S., Amini-Rarani, M., Amit, A.M.L., Amugsi, D.A., Ancuceanu, R., Anderlini, D., Andrei, C.L., Ansari, F., Ansari-Moghaddam, A., Antonio, C.A.T., Antriyandarti, E., Anvari, D., Anwer, R., Aqeel, M., Arabloo, J., Arab-Zozani, M., Aripov, T., Ärnlöv, J., Artanti, K.D., Arzani, A., Asaad, M., Asadi-Aliabadi, M., Asadi-Pooya, A.A., Asghari Jafarabadi, M., Athari, S.S., Athari, S.M., Atnafu, D.D., Atreya, A., Atteraya, M.S., Ausloos, M., Awan, A.T., Ayala Quintanilla, B.P., Ayano, G., Ayanore, M.A., Aynalem, Y.A., Azari, S., Azarian, G., Azene, Z.N., B, D.B., Babaee, E., Badiye, A.D., Baig, A.A., Banach, M., Banik, P.C., Barker-Collo, S.L., Barqawi, H.J., Bassat, Q., Basu, S., Baune, B.T., Bayati, M., Bedi, N., Beghi, E., Beghi, M., Bell, M.L., Bendak, S., Bennett, D.A., Bensenor, I.M., Berhe, K., Berman, A.E., Bezabih, Y.M., Bhagavathula, A.S., Bhandari, D., Bhardwaj, N., Bhardwaj, P., Bhattacharyya, K., Bhattarai, S., Bhutta, Z.A., Bikbov, B., Biondi, A., Birihane, B.M., Biswas, R.K., Bohlouli, S., Bragazzi, N.L., Breusov, A.V., Brunoni, A.R., Burkart, K., Burugina Nagaraja, S., Busse, R., Butt, Z.A., Caetano dos Santos, F.L., Cahuana-Hurtado, L., Camargos, P., Cámera, L.A., Cárdenas, R., Carreras, G., Carrero, J.J., Carvalho, F., Castaldelli-Maia, J.M., Castañeda-Orjuela, C.A., Castelpietra, G., Cerin, E., Chang, J.-C., Chanie, W.F., Charan, J., Chatterjee, S., Chattu, S.K., Chattu, V.K., Chaturvedi, S., Chen, S., Cho, D.Y., Choi, J.-Y.J., Chu, D.-T., Ciobanu, L.G., Cirillo, M., Conde, J., Costa, V.M., Couto, R.A.S., Dachew, B.A., Dahlawi, S.M.A., Dai, H., Dai, X., Dandona, L., Dandona, R., Daneshpajouhnejad, P., Darmstadt, G.L., Das, J.K., Dávila-Cervantes, C.A., Davis, A.C., Davletov, K., De la Hoz, F.P., De Leo, D., Deeba, F., Denova-Gutiérrez, E., Dervenis, N., Desalew, A., Deuba, K., Dey, S., Dharmaratne, S.D., Dhingra, S., Dhungana, G.P., Dias da Silva, D., Diaz, D., Dorostkar, F., Doshmangir, L., Dubljanin, E., Duraes, A.R., Eagan, A.W., Edinur, H.A., Efendi, F., Eftekharzadeh, S., El Sayed, I., El Tantawi, M., Elbarazi, I., Elgendy, I.Y., El-Jaafary, S.I., Emami, A., Enany, S., Eyawo, O., Ezzikouri, S., Faris, P.S., Farzadfar, F., Fattahi, N., Fauk, N.K., Fazlzadeh, M., Feigin, V.L., Ferede, T.Y., Fereshtehnejad, S.-M., Fernandes, E., Ferrara, P., Filip, I., Fischer, F., Fisher, J.L., Foigt, N.A., Folayan, M.O., Foroutan, M., Franklin, R.C., Freitas, M., Friedman, S.D., Fukumoto, T., Gad, M.M., Gaidhane, A.M., Gaidhane, S., Gaihre, S., Gallus, S., Garcia-Basteiro, A.L., Garcia-Gordillo, M.A., Gardner, W.M., Gaspar Fonseca, M., Gebremedhin, K.B., Getacher, L., Ghashghaee, A., Gholamian, A., Gilani, S.A., Gill, T.K., Giussani, G., Gnedovskaya, E.V., Godinho, M.A., Goel, A., Golechha, M., Gona, P.N., Gopalani, S.V., Goudarzi, H., Grivna, M., Gugnani, H.C., Guido, D., Guimarães, R.A., Gupta, R.D., Gupta, R., Hafezi-Nejad, N., Haider, M.R., Haj-Mirzaian, A., Hamidi, S., Hanif, A., Hankey, G.J., Hargono, A., Hasaballah, A.I., Hasan, M.M., Hasan, S.S., Hassan, A., Hassanipour, S., Hassankhani, H., Havmoeller, R.J., Hayat, K., Heidari-Soureshjani, R., Henry, N.J., Herteliu, C., Hole, M.K., Holla, R., Hossain, N., Hosseini, M., Hosseinzadeh, M., Hostiuc, M., Hostiuc, S., Househ, M., Huang, J., Humayun, A., Hwang, B.-F., Iavicoli, I., Ibitoye, S.E., Ikuta, K.S., Ilesanmi, O.S., Ilic, I.M., Ilic, M.D., Inamdar, S., Inbaraj, L.R., Iqbal, K., Iqbal, U., Islam, M.M., Islam, S.M.S., Iso, H., Iwagami, M., Iwu, C.C.D., Jaafari, J., Jacobsen, K.H., Jagnoor, J., Jain, V., Janodia, M.D., Javaheri, T., Javanmardi, F., Jayaram, S., Jayatilleke, A.U., Jenabi, E., Jha, R.P., Ji, J.S., John, O., Jonas, J.B., Joo, T., Joseph, N., Joukar, F., Jozwiak, J.J., Jürisson, M., Kabir, A., Kabir, Z., Kalankesh, L.R., Kamyari, N., Kanchan, T., Kapoor, N., Karami Matin, B., Karch, A., Karimi, S.E., Kassahun, G., Kayode, G.A., Kazemi Karyani, A., Kemmer, L., Khalid, N., Khalilov, R., Khammarnia, M., Khan, E.A., Khan, G., Khan, M., Khan, M.N., Khang, Y.-H., Khatab, K., Khater, A.M., Khater, M.M., Khayamzadeh, M., Khosravi, A., Kim, D., Kim, Y.-E., Kim, Y.J., Kimokoti, R.W., Kisa, A., Kisa, S., Kissoon, N., Kopec, J.A., Kosen, S., Koul, P.A., Koulmane Laxminarayana, S.L., Koyanagi, A., Krishan, K., Krishnamoorthy, V., Kuate Defo, B., Kucuk Bicer, B., Kulkarni, V., Kumar, G.A., Kumar, M., Kumar, N., Kurmi, O.P., Kusuma, D., La Vecchia, C., Lacey, B., Lalloo, R., Lami, F.H., Landires, I., Larsson, A.O., Lasrado, S., Lassi, Z.S., Lauriola, P., Lee, P.H., Lee, S.W.H., Lee, Y.H., Leigh, J., Leonardi, M., Lewycka, S., Li, B., Li, S., Liang, J., Lim, L.-L., Limenih, M.A., Lin, R.-T., Liu, X., Lodha, R., Lopez, A.D., Lozano, R., Lugo, A., Lunevicius, R., Mackay, M.T., Madhava Kunjathur, S., Magnani, F.G., Mahadeshwara Prasad, D.R., Maheri, M., Mahmoudi, M., Majeed, A., Maled, V., Maleki, A., Maleki, S., Malekzadeh, R., Malik, A.A., Malta, D.C., Mamun, A.A., Mansouri, B., Mansournia, M.A., Martinez, G., Martini, S., Martins-Melo, F.R., Masoumi, S.Z., Maulik, P.K., McAlinden, C., McGrath, J.J., Medina-Solís, C.E., Mehrabi Nasab, E., Mejia-Rodriguez, F., Memish, Z.A., Mendoza, W., Menezes, R.G., Mengesha, E.W., Mensah, G.A., Meretoja, A., Meretoja, T.J., Mersha, A.M., Mestrovic, T., Miazgowski, B., Miazgowski, T., Michalek, I.M., Miller, T.R., Mini, G.K., Miri, M., Mirica, A., Mirrakhimov, E.M., Mirzaei, H., Mirzaei, M., Moazen, B., Moghadaszadeh, M., Mohajer, B., Mohamad, O., Mohammad, Y., Mohammadi, S.M., Mohammadian-Hafshejani, A., Mohammed, S., Mokdad, A.H., Molokhia, M., Monasta, L., Mondello, S., Moni, M.A., Moore, C.E., Moradi, G., Moradi, M., Moradzadeh, R., Moraga, P., Morawska, L., Morrison, S.D., Mosser, J.F., Mousavi Khaneghah, A., Mustafa, G., Naderi, M., Nagarajan, A.J., Nagaraju, S.P., Naghavi, M., Naghshtabrizi, B., Naimzada, M.D., Nangia, V., Narasimha Swamy, S., Nascimento, B.R., Naveed, M., Nazari, J., Ndejjo, R., Negoi, I., Negoi, R.I., Nena, E., Nepal, S., Netsere, H.B., Nguefack-Tsague, G., Ngunjiri, J.W., Nguyen, C.T.Y., Nguyen, C.T., Nguyen, H.L.T., Nigatu, Y.T., Nigussie, S.N., Nixon, M.R., Nnaji, C.A., Nomura, S., Noor, N.M., Noubiap, J.J., Nuñez-Samudio, V., Nwatah, V.E., Oancea, B., Odukoya, O.O., Ogbo, F.A., Olusanya, B.O., Olusanya, J.O., Omar Bali, A., Onwujekwe, O.E., Ortiz, A., Otoiu, A., Otstavnov, N., Otstavnov, S.S., Owolabi, M.O., P A, M., Padubidri, J.R., Pakhale, S., Pakshir, K., Pal, P.K., Palladino, R., Pana, A., Panda-Jonas, S., Pandey, A., Pandey, A., Pandi-Perumal, S.R., Pangaribuan, H.U., Pardo-Montaño, A.M., Park, E.-K., Patel, S.K., Patton, G.C., Pawar, S., Pazoki Toroudi, H., Peden, A.E., Pepito, V.C.F., Peprah, E.K., Pereira, J., Pérez-Gómez, J., Perico, N., Pesudovs, K., Pilgrim, T., Pinheiro, M., Piradov, M.A., Pirsaheb, M., Platts-Mills, J.A., Pokhrel, K.N., Postma, M.J., Pourjafar, H., Prada, S.I., Prakash, S., Pupillo, E., Quazi Syed, Z., Rabiee, N., Radfar, A., Rafiee, A., Rafiei, A., Raggi, A., Rahimzadeh, S., Rahman, M.H.U., Rahmani, A.M., Ramezanzadeh, K., Rana, J., Ranabhat, C.L., Rao, S.J., Rasella, D., Rastogi, P., Rathi, P., Rawaf, D.L., Rawaf, S., Rawasia, W.F., Rawassizadeh, R., Reiner, R.C., Remuzzi, G., Renzaho, A.M.N., Reshmi, B., Resnikoff, S., Rezaei, N., Rezaei, N., Rezapour, A., Riahi, S.M., Ribeiro, D., Rickard, J., Roever, L., Ronfani, L., Rothenbacher, D., Rubagotti, E., Rumisha, S.F., Ryan, P.M., Saddik, B., Sadeghi, E., Saeedi Moghaddam, S., Sagar, R., Sahebkar, A., Salahshoor, M.R., Salehi, S., Salem, M.R., Salimzadeh, H., Salomon, J.A., Samodra, Y.L., Samy, A.M., Sanabria, J., Santric-Milicevic, M.M., Saraswathy, S.Y.I., Sarker, A.R., Sarrafzadegan, N., Sarveazad, A., Sathian, B., Sathish, T., Sattin, D., Saxena, S., Saya, G.K., Saylan, M., Schiavolin, S., Schlaich, M.P., Schwebel, D.C., Schwendicke, F., Senthilkumaran, S., Sepanlou, S.G., Serván-Mori, E., Sha, F., Shafaat, O., Shahabi, S., Shahbaz, M., Shaheen, A.A., Shahid, I., Shaikh, M.A., Shakiba, S., Shalash, A.S., Shams-Beyranvand, M., Shannawaz, M., Sharafi, K., Sheikh, A., Sheikhbahaei, S., Shiferaw, W.S., Shigematsu, M., Shin, J.I., Shiri, R., Shiue, I., Shuval, K., Siddiqi, T.J., Sidemo, N.B., Sigfusdottir, I.D., Sigurvinsdottir, R., Silva, J.P., Silverberg, J.I.S., Simonetti, B., Singh, B.B., Singh, J.A., Singhal, D., Sinha, D.N., Skiadaresi, E., Skryabin, V.Y., Skryabina, A.A., Sleet, D.A., Sobaih, B.H., Sobhiyeh, M.R., Soltani, S., Soriano, J.B., Spurlock, E.E., Sreeramareddy, C.T., Steiropoulos, P., Stokes, M.A., Stortecky, S., Sufiyan, M.B., Suliankatchi Abdulkader, R., Sulo, G., Swope, C.B., Sykes, B.L., Szeto, M.D., Szócska, M., Tabarés-Seisdedos, R., Tadesse, E.G., Taherkhani, A., Tamiru, A.T., Tareque, M.I., Tehrani-Banihashemi, A., Temsah, M.-H., Tesfay, F.H., Tessema, G.A., Tessema, Z.T., Thankappan, K.R., Thapar, R., Tolani, M.A., Tovani-Palone, M.R., Traini, E., Tran, B.X., Tripathy, J.P., Tsapparellas, G., Tsatsakis, A., Tudor Car, L., Uddin, R., Ullah, A., Umeokonkwo, C.D., Unim, B., Unnikrishnan, B., Upadhyay, E., Usman, M.S., Vacante, M., Vaezi, M., Valadan Tahbaz, S., Valdez, P.R., Vasankari, T.J., Venketasubramanian, N., Verma, M., Violante, F.S., Vlassov, V., Vo, B., Vu, G.T., Wado, Y.D., Waheed, Y., Wamai, R.G., Wang, Y., Wang, Y., Wang, Y.-P., Ward, P., Werdecker, A., Westerman, R., Wickramasinghe, N.D., Wilner, L.B., Wiysonge, C.S., Wu, A.-M., Wu, C., Xie, Y., Yahyazadeh Jabbari, S.H., Yamagishi, K., Yandrapalli, S., Yaya, S., Yazdi-Feyzabadi, V., Yip, P., Yonemoto, N., Yoon, S.-J., Younis, M.Z., Yousefi, Z., Yousefinezhadi, T., Yu, C., Yusuf, S.S., Zaidi, S.S., Zaman, S.B., Zamani, M., Zamanian, M., Zastrozhin, M.S., Zastrozhina, A., Zhang, Y., Zhang, Z.-J., Zhao, X.-J.G., Ziapour, A., Hay, S.I., Murray, C.J.L., Wang, H. and Kassebaum, N.J. (2021). Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019. The Lancet. https://doi.org/10.1016/s0140-6736(21)01207-1
AuthorsPaulson, K.R., Kamath, A.M., Alam, T., Bienhoff, K., Abady, G.G., Abbas, J., Abbasi-Kangevari, M., Abbastabar, H., Abd-Allah, F., Abd-Elsalam, S.M., Abdoli, A., Abedi, A., Abolhassani, H., Abreu, L.G., Abu-Gharbieh, E., Abu-Rmeileh, N.M., Abushouk, A.I., Adamu, A.L., Adebayo, O.M., Adegbosin, A.E., Adekanmbi, V., Adetokunboh, O.O., Adeyinka, D.A., Adsuar, J.C., Afshari, K., Aghaali, M., Agudelo-Botero, M., Ahinkorah, B.O., Ahmad, T., Ahmadi, K., Ahmed, M.B., Aji, B., Akalu, Y., Akinyemi, O.O., Aklilu, A., Al-Aly, Z., Alam, K., Alanezi, F.M., Alanzi, T.M., Alcalde-Rabanal, J.E., Al-Eyadhy, A., Ali, T., Alicandro, G., Alif, S.M., Alipour, V., Alizade, H., Aljunid, S.M., Almasi-Hashiani, A., Almasri, N.A., Al-Mekhlafi, H.M., Alonso, J., Al-Raddadi, R.M., Altirkawi, K.A., Alumran, A.K., Alvis-Guzman, N., Alvis-Zakzuk, N.J., Ameyaw, E.K., Amini, S., Amini-Rarani, M., Amit, A.M.L., Amugsi, D.A., Ancuceanu, R., Anderlini, D., Andrei, C.L., Ansari, F., Ansari-Moghaddam, A., Antonio, C.A.T., Antriyandarti, E., Anvari, D., Anwer, R., Aqeel, M., Arabloo, J., Arab-Zozani, M., Aripov, T., Ärnlöv, J., Artanti, K.D., Arzani, A., Asaad, M., Asadi-Aliabadi, M., Asadi-Pooya, A.A., Asghari Jafarabadi, M., Athari, S.S., Athari, S.M., Atnafu, D.D., Atreya, A., Atteraya, M.S., Ausloos, M., Awan, A.T., Ayala Quintanilla, B.P., Ayano, G., Ayanore, M.A., Aynalem, Y.A., Azari, S., Azarian, G., Azene, Z.N., B, D.B., Babaee, E., Badiye, A.D., Baig, A.A., Banach, M., Banik, P.C., Barker-Collo, S.L., Barqawi, H.J., Bassat, Q., Basu, S., Baune, B.T., Bayati, M., Bedi, N., Beghi, E., Beghi, M., Bell, M.L., Bendak, S., Bennett, D.A., Bensenor, I.M., Berhe, K., Berman, A.E., Bezabih, Y.M., Bhagavathula, A.S., Bhandari, D., Bhardwaj, N., Bhardwaj, P., Bhattacharyya, K., Bhattarai, S., Bhutta, Z.A., Bikbov, B., Biondi, A., Birihane, B.M., Biswas, R.K., Bohlouli, S., Bragazzi, N.L., Breusov, A.V., Brunoni, A.R., Burkart, K., Burugina Nagaraja, S., Busse, R., Butt, Z.A., Caetano dos Santos, F.L., Cahuana-Hurtado, L., Camargos, P., Cámera, L.A., Cárdenas, R., Carreras, G., Carrero, J.J., Carvalho, F., Castaldelli-Maia, J.M., Castañeda-Orjuela, C.A., Castelpietra, G., Cerin, E., Chang, J.-C., Chanie, W.F., Charan, J., Chatterjee, S., Chattu, S.K., Chattu, V.K., Chaturvedi, S., Chen, S., Cho, D.Y., Choi, J.-Y.J., Chu, D.-T., Ciobanu, L.G., Cirillo, M., Conde, J., Costa, V.M., Couto, R.A.S., Dachew, B.A., Dahlawi, S.M.A., Dai, H., Dai, X., Dandona, L., Dandona, R., Daneshpajouhnejad, P., Darmstadt, G.L., Das, J.K., Dávila-Cervantes, C.A., Davis, A.C., Davletov, K., De la Hoz, F.P., De Leo, D., Deeba, F., Denova-Gutiérrez, E., Dervenis, N., Desalew, A., Deuba, K., Dey, S., Dharmaratne, S.D., Dhingra, S., Dhungana, G.P., Dias da Silva, D., Diaz, D., Dorostkar, F., Doshmangir, L., Dubljanin, E., Duraes, A.R., Eagan, A.W., Edinur, H.A., Efendi, F., Eftekharzadeh, S., El Sayed, I., El Tantawi, M., Elbarazi, I., Elgendy, I.Y., El-Jaafary, S.I., Emami, A., Enany, S., Eyawo, O., Ezzikouri, S., Faris, P.S., Farzadfar, F., Fattahi, N., Fauk, N.K., Fazlzadeh, M., Feigin, V.L., Ferede, T.Y., Fereshtehnejad, S.-M., Fernandes, E., Ferrara, P., Filip, I., Fischer, F., Fisher, J.L., Foigt, N.A., Folayan, M.O., Foroutan, M., Franklin, R.C., Freitas, M., Friedman, S.D., Fukumoto, T., Gad, M.M., Gaidhane, A.M., Gaidhane, S., Gaihre, S., Gallus, S., Garcia-Basteiro, A.L., Garcia-Gordillo, M.A., Gardner, W.M., Gaspar Fonseca, M., Gebremedhin, K.B., Getacher, L., Ghashghaee, A., Gholamian, A., Gilani, S.A., Gill, T.K., Giussani, G., Gnedovskaya, E.V., Godinho, M.A., Goel, A., Golechha, M., Gona, P.N., Gopalani, S.V., Goudarzi, H., Grivna, M., Gugnani, H.C., Guido, D., Guimarães, R.A., Gupta, R.D., Gupta, R., Hafezi-Nejad, N., Haider, M.R., Haj-Mirzaian, A., Hamidi, S., Hanif, A., Hankey, G.J., Hargono, A., Hasaballah, A.I., Hasan, M.M., Hasan, S.S., Hassan, A., Hassanipour, S., Hassankhani, H., Havmoeller, R.J., Hayat, K., Heidari-Soureshjani, R., Henry, N.J., Herteliu, C., Hole, M.K., Holla, R., Hossain, N., Hosseini, M., Hosseinzadeh, M., Hostiuc, M., Hostiuc, S., Househ, M., Huang, J., Humayun, A., Hwang, B.-F., Iavicoli, I., Ibitoye, S.E., Ikuta, K.S., Ilesanmi, O.S., Ilic, I.M., Ilic, M.D., Inamdar, S., Inbaraj, L.R., Iqbal, K., Iqbal, U., Islam, M.M., Islam, S.M.S., Iso, H., Iwagami, M., Iwu, C.C.D., Jaafari, J., Jacobsen, K.H., Jagnoor, J., Jain, V., Janodia, M.D., Javaheri, T., Javanmardi, F., Jayaram, S., Jayatilleke, A.U., Jenabi, E., Jha, R.P., Ji, J.S., John, O., Jonas, J.B., Joo, T., Joseph, N., Joukar, F., Jozwiak, J.J., Jürisson, M., Kabir, A., Kabir, Z., Kalankesh, L.R., Kamyari, N., Kanchan, T., Kapoor, N., Karami Matin, B., Karch, A., Karimi, S.E., Kassahun, G., Kayode, G.A., Kazemi Karyani, A., Kemmer, L., Khalid, N., Khalilov, R., Khammarnia, M., Khan, E.A., Khan, G., Khan, M., Khan, M.N., Khang, Y.-H., Khatab, K., Khater, A.M., Khater, M.M., Khayamzadeh, M., Khosravi, A., Kim, D., Kim, Y.-E., Kim, Y.J., Kimokoti, R.W., Kisa, A., Kisa, S., Kissoon, N., Kopec, J.A., Kosen, S., Koul, P.A., Koulmane Laxminarayana, S.L., Koyanagi, A., Krishan, K., Krishnamoorthy, V., Kuate Defo, B., Kucuk Bicer, B., Kulkarni, V., Kumar, G.A., Kumar, M., Kumar, N., Kurmi, O.P., Kusuma, D., La Vecchia, C., Lacey, B., Lalloo, R., Lami, F.H., Landires, I., Larsson, A.O., Lasrado, S., Lassi, Z.S., Lauriola, P., Lee, P.H., Lee, S.W.H., Lee, Y.H., Leigh, J., Leonardi, M., Lewycka, S., Li, B., Li, S., Liang, J., Lim, L.-L., Limenih, M.A., Lin, R.-T., Liu, X., Lodha, R., Lopez, A.D., Lozano, R., Lugo, A., Lunevicius, R., Mackay, M.T., Madhava Kunjathur, S., Magnani, F.G., Mahadeshwara Prasad, D.R., Maheri, M., Mahmoudi, M., Majeed, A., Maled, V., Maleki, A., Maleki, S., Malekzadeh, R., Malik, A.A., Malta, D.C., Mamun, A.A., Mansouri, B., Mansournia, M.A., Martinez, G., Martini, S., Martins-Melo, F.R., Masoumi, S.Z., Maulik, P.K., McAlinden, C., McGrath, J.J., Medina-Solís, C.E., Mehrabi Nasab, E., Mejia-Rodriguez, F., Memish, Z.A., Mendoza, W., 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Abstract

Background
Sustainable Development Goal 3.2 has targeted elimination of preventable child mortality, reduction of neonatal death to less than 12 per 1000 livebirths, and reduction of death of children younger than 5 years to less than 25 per 1000 livebirths, for each country by 2030. To understand current rates, recent trends, and potential trajectories of child mortality for the next decade, we present the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 findings for all-cause mortality and cause-specific mortality in children younger than 5 years of age, with multiple scenarios for child mortality in 2030 that include the consideration of potential effects of COVID-19, and a novel framework for quantifying optimal child survival.
Methods
We completed all-cause mortality and cause-specific mortality analyses from 204 countries and territories for detailed age groups separately, with aggregated mortality probabilities per 1000 livebirths computed for neonatal mortality rate (NMR) and under-5 mortality rate (U5MR). Scenarios for 2030 represent different potential trajectories, notably including potential effects of the COVID-19 pandemic and the potential impact of improvements preferentially targeting neonatal survival. Optimal child survival metrics were developed by age, sex, and cause of death across all GBD location-years. The first metric is a global optimum and is based on the lowest observed mortality, and the second is a survival potential frontier that is based on stochastic frontier analysis of observed mortality and Healthcare Access and Quality Index.
Findings
Global U5MR decreased from 71·2 deaths per 1000 livebirths (95% uncertainty interval [UI] 68·3–74·0) in 2000 to 37·1 (33·2–41·7) in 2019 while global NMR correspondingly declined more slowly from 28·0 deaths per 1000 live births (26·8–29·5) in 2000 to 17·9 (16·3–19·8) in 2019. In 2019, 136 (67%) of 204 countries had a U5MR at or below the SDG 3.2 threshold and 133 (65%) had an NMR at or below the SDG 3.2 threshold, and the reference scenario suggests that by 2030, 154 (75%) of all countries could meet the U5MR targets, and 139 (68%) could meet the NMR targets. Deaths of children younger than 5 years totalled 9·65 million (95% UI 9·05–10·30) in 2000 and 5·05 million (4·27–6·02) in 2019, with the neonatal fraction of these deaths increasing from 39% (3·76 million [95% UI 3·53–4·02]) in 2000 to 48% (2·42 million; 2·06–2·86) in 2019. NMR and U5MR were generally higher in males than in females, although there was no statistically significant difference at the global level. Neonatal disorders remained the leading cause of death in children younger than 5 years in 2019, followed by lower respiratory infections, diarrhoeal diseases, congenital birth defects, and malaria. The global optimum analysis suggests NMR could be reduced to as low as 0·80 (95% UI 0·71–0·86) deaths per 1000 livebirths and U5MR to 1·44 (95% UI 1·27–1·58) deaths per 1000 livebirths, and in 2019, there were as many as 1·87 million (95% UI 1·35–2·58; 37% [95% UI 32–43]) of 5·05 million more deaths of children younger than 5 years than the survival potential frontier.
Interpretation
Global child mortality declined by almost half between 2000 and 2019, but progress remains slower in neonates and 65 (32%) of 204 countries, mostly in sub-Saharan Africa and south Asia, are not on track to meet either SDG 3.2 target by 2030. Focused improvements in perinatal and newborn care, continued and expanded delivery of essential interventions such as vaccination and infection prevention, an enhanced focus on equity, continued focus on poverty reduction and education, and investment in strengthening health systems across the development spectrum have the potential to substantially improve U5MR. Given the widespread effects of COVID-19, considerable effort will be required to maintain and accelerate progress.

Year2021
JournalThe Lancet
PublisherElsevier
ISSN1474-547X
Digital Object Identifier (DOI)https://doi.org/10.1016/s0140-6736(21)01207-1
Web address (URL)http://www.scopus.com/inward/record.url?eid=2-s2.0-85114514329&partnerID=MN8TOARS
Publication dates
Online17 Aug 2021
Publication process dates
Deposited25 Jul 2022
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Open
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Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems
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Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019
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Predicting the environmental suitability for onchocerciasis in Africa as an aid to elimination planning.
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Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000–17
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Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000–17
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Five insights from the Global Burden of Disease Study 2019
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Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019
Abbafati, C, Machado, DB, Cislaghi, B, Salman, OM, Karanikolos, M, McKee, M, Abbas, KM, Brady, OJ, Larson, HJ, Trias-Llimós, S, Cummins, S, Langan, SM, Sartorius, B, Hafiz, A, Jenabi, E, Mohammad Gholi Mezerji, N, Borzouei, S, Azarian, G, Khazaei, S, Abbasi, M, Asghari, B, Masoumi, S, Komaki, H, Taherkhani, A, Adabi, M, Abbasifard, M, Bazmandegan, G, Kamiab, Z, Vakilian, A, Anjomshoa, M, Mokari, A, Sabour, S, Shahbaz, M, Saeedi, R, Ahmadieh, H, Yousefinezhadi, T, Haj-Mirzaian, A, Nikbakhsh, R, Safi, S, Asgari, S, Irvani, SN, Jahanmehr, N, Ramezanzadeh, K, Abbasi-Kangevari, M, Khayamzadeh, M, Abbastabar, H, Shirkoohi, R, Fazlzadeh, M, Janjani, H, Hosseini, M, Mansournia, M, Tohidinik, H, Bakhtiari, A, Fazaeli, A, Mousavi, S, Hasanzadeh, A, Nabavizadeh, B, Malekzadeh, R, Hashemian, M, Pourshams, A, Salimzadeh, H, Sepanlou, SG, Afarideh, M, Esteghamati, A, Esteghamati, S, Ghajar, A, Heidari, B, Rezaei, N, Mohamadi, E, Rahimi-Movaghar, A, Rahim, F, Eskandarieh, S, Sahraian, M, Mohebi, F, Aminorroaya, A, Ebrahimi, H, Farzadfar, F, Mohajer, B, Pishgar, F, Saeedi Moghaddam, S, Shabani, M, Zarafshan, H, Abolhassani, H, Hafezi-Nejad, N, Heidari-Soureshjani, R, Abdollahi, M, Farahmand, M, Salamati, P, Mehrabi Nasab, E, Tajdini, M, Aghamir, S, Mirzaei, R, Dibaji Forooshani, Z, Khater, MM, Abd-Allah, F, Abdelalim, A, Abualhasan, A, El-Jaafary, SI, Hassan, A, Elsharkawy, A and Herteliu, C. (2020). Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019. The Lancet. 396 (10258), pp. 1160-1203. https://doi.org/10.1016/S0140-6736(20)30977-6
Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
Abbafati, C, Machado, DB, Cislaghi, B, Salman, OM, Karanikolos, M, McKee, M, Abbas, KM, Brady, OJ, Larson, HJ, Trias-Llimós, S, Cummins, S, Langan, SM, Sartorius, B, Hafiz, A, Jenabi, E, Mohammad Gholi Mezerji, N, Borzouei, S, Azarian, G, Khazaei, S, Abbasi, M, Asghari, B, Masoumi, S, Komaki, H, Taherkhani, A, Adabi, M, Abbasifard, M, Bazmandegan, G, Kamiab, Z, Vakilian, A, Anjomshoa, M, Mokari, A, Sabour, S, Shahbaz, M, Saeedi, R, Ahmadieh, H, Yousefinezhadi, T, Haj-Mirzaian, A, Nikbakhsh, R, Safi, S, Asgari, S, Irvani, SN, Jahanmehr, N, Ramezanzadeh, K, Abbasi-Kangevari, M, Khayamzadeh, M, Abbastabar, H, Shirkoohi, R, Fazlzadeh, M, Janjani, H, Hosseini, M, Mansournia, M, Tohidinik, H, Bakhtiari, A, Fazaeli, A, Mousavi, S, Hasanzadeh, A, Nabavizadeh, B, Malekzadeh, R, Hashemian, M, Pourshams, A, Salimzadeh, H, Sepanlou, SG, Afarideh, M, Esteghamati, A, Esteghamati, S, Ghajar, A, Heidari, B, Rezaei, N, Mohamadi, E, Rahimi-Movaghar, A, Rahim, F, Eskandarieh, S, Sahraian, M, Mohebi, F, Aminorroaya, A, Ebrahimi, H, Farzadfar, F, Mohajer, B, Pishgar, F, Saeedi Moghaddam, S, Shabani, M, Zarafshan, H, Abolhassani, H, Hafezi-Nejad, N, Heidari-Soureshjani, R, Abdollahi, M, Farahmand, M, Salamati, P, Mehrabi Nasab, E, Tajdini, M, Aghamir, S, Mirzaei, R, Dibaji Forooshani, Z, Khater, MM, Abd-Allah, F, Abdelalim, A, Abualhasan, A, El-Jaafary, SI, Hassan, A, Elsharkawy, A, Ausloos, M. and Herteliu, C. (2020). Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet. 396 (10258), pp. 1204-1222. https://doi.org/10.1016/S0140-6736(20)30925-9
Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
Abbafati, C, Machado, DB, Cislaghi, B, Salman, OM, Karanikolos, M, McKee, M, Abbas, KM, Brady, OJ, Larson, HJ, Trias-Llimós, S, Cummins, S, Langan, SM, Sartorius, B, Hafiz, A, Jenabi, E, Mohammad Gholi Mezerji, N, Borzouei, S, Azarian, G, Khazaei, S, Abbasi, M, Asghari, B, Masoumi, S, Komaki, H, Taherkhani, A, Adabi, M, Abbasifard, M, Bazmandegan, G, Kamiab, Z, Vakilian, A, Anjomshoa, M, Mokari, A, Sabour, S, Shahbaz, M, Saeedi, R, Ahmadieh, H, Yousefinezhadi, T, Haj-Mirzaian, A, Nikbakhsh, R, Safi, S, Asgari, S, Irvani, SN, Jahanmehr, N, Ramezanzadeh, K, Abbasi-Kangevari, M, Khayamzadeh, M, Abbastabar, H, Shirkoohi, R, Fazlzadeh, M, Janjani, H, Hosseini, M, Mansournia, M, Tohidinik, H, Bakhtiari, A, Fazaeli, A, Mousavi, S, Hasanzadeh, A, Nabavizadeh, B, Malekzadeh, R, Hashemian, M, Pourshams, A, Salimzadeh, H, Sepanlou, SG, Afarideh, M, Esteghamati, A, Esteghamati, S, Ghajar, A, Heidari, B, Rezaei, N, Mohamadi, E, Rahimi-Movaghar, A, Rahim, F, Eskandarieh, S, Sahraian, M, Mohebi, F, Aminorroaya, A, Ebrahimi, H, Farzadfar, F, Mohajer, B, Pishgar, F, Saeedi Moghaddam, S, Shabani, M, Zarafshan, H, Abolhassani, H, Hafezi-Nejad, N, Heidari-Soureshjani, R, Abdollahi, M, Farahmand, M, Salamati, P, Mehrabi Nasab, E, Tajdini, M, Aghamir, S, Mirzaei, R, Dibaji Forooshani, Z, Khater, MM, Abd-Allah, F, Abdelalim, A, Abualhasan, A, El-Jaafary, SI, Hassan, A, Elsharkawy, A and Herteliu, C. (2020). Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet. 396 (10258), pp. 1223-1249. https://doi.org/10.1016/S0140-6736(20)30752-2
Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
Lozano, R, Fullman, N, Mumford, JE, Knight, M, Barthelemy, CM, Abbafati, C, Abbastabar, H, Abd-Allah, F, Abdollahi, M, Abedi, A, Abolhassani, H, Abosetugn, AE, Abreu, LG, Abrigo, MRM, Abu Haimed, AK, Abushouk, AI, Adabi, M, Adebayo, OM, Adekanmbi, V, Adelson, J, Adetokunboh, OO, Adham, D, Advani, SM, Afshin, A, Agarwal, G, Agasthi, P, Aghamir, SMK, Agrawal, A, Ahmad, T, Akinyemi, RO, Alahdab, F, Al-Aly, Z, Alam, K, Albertson, SB, Alemu, YM, Alhassan, RK, Ali, M, Ali, S, Alipour, V, Aljunid, SM, Alla, F, Almadi, MAH, Almasi, A, Almasi-Hashiani, A, Almasri, NA, Al-Mekhlafi, HM, Almulhim, AM, Alonso, J, Al-Raddadi, RM, Altirkawi, KA, Alvis-Guzman, N, Alvis-Zakzuk, NJ, Amini, S, Amini-Rarani, M, Amiri, F, Amit, AML, Amugsi, DA, Ancuceanu, R, Anderlini, D, Andrei, CL, Androudi, S, Ansari, F, Ansari-Moghaddam, A, Antonio, CAT, Antony, CM, Antriyandarti, E, Anvari, D, Anwer, R, Arabloo, J, Arab-Zozani, M, Aravkin, AY, Aremu, O, Ärnlöv, J, Asaad, M, Asadi-Aliabadi, M, Asadi-Pooya, AA, Athari, SS, Atout, MMDW, Ausloos, M, Avila-Burgos, L, Ayala Quintanilla, BP, Ayano, G, Ayanore, MA, Aynalem, YA, Aynalem, GL, Ayza, MA, Azari, S, Azzopardi, PS, B, DB, Babaee, E, Badiye, AD, Bahrami, MA, Baig, AA, Bakhshaei, MH, Bakhtiari, A, Bakkannavar, SM, Balachandran, A, Banach, M, Banerjee, SK, Banik, PC and Herteliu, C. (2020). Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet. 396 (10258), pp. 1250-1284. https://doi.org/10.1016/S0140-6736(20)30750-9
The global distribution of lymphatic filariasis, 2000–18: a geospatial analysis
Deshpande, A, Miller-Petrie, MK, Johnson, KB, Abdoli, A, Abrigo, MRM, Adekanmbi, V, Adetokunboh, OO, Adinarayanan, S, Ahmadpour, E, Ahmed, MB, Akalu, TY, Alanzi, TM, Alinia, C, Alipour, V, Amit, AML, Anber, NH, Ancuceanu, R, Andualem, Z, Ansari, F, Antonio, CAT, Anvari, D, Appiah, S, Arabloo, J, Arnold, BF, Ausloos, M, Ayanore, MA, Badirzadeh, A, Baig, AA, Banach, M, Baraki, AG, Bärnighausen, TW, Bayati, M, Bhattacharyya, K, Bhutta, ZA, Bijani, A, Bockarie, MJ, Bisanzio, D, Biswas, RK, Bohlouli, S, Cano, J, Carvalho, F, Chattu, VK, Chavshin, C, Cormier, NM, Cromwell, EA, Schmidt, CA, Kwong, KT, Damiani, G, Dandona, R, Dandona, L, Darwesh, AM, Daryani, A, Dash, AP, Deribe, K, Dessu, B, Dhimal, M, Dianatinasab, M, Diaz, D, Do, HT, Earl, L, El Tantawi, M, Faraj, A, Fattahi, N, Fernandes, E, Fischer, F, Foigt, NA, Foroutan, M, Guo, Y, Hailu, GB, Hasaballah, AI, Hassankhani, H, Hassankhani, H, Herteliu, C, de Hidru, HD, Hon, J, Hole, MK, Hossain, N, Hosseinzadeh, M, Househ, M, Humayun, A, Ilesanmi, OS, Ilic, MD, Iqbal, U, Irvani, SSN, Islam, SMS, Jha, RP, Ji, JS, Jozwiak, JJ, Kabir, A, Kalankesh, LR, Kalhor, R, Karami Matin, B, Karch, A, Karimi, S, Kasaeian, A, Kazemi Karyani, A, Kayode, GA, Kelbore, AG, Khafaie, MA and Khalilov, R (2020). The global distribution of lymphatic filariasis, 2000–18: a geospatial analysis. The Lancet Global Health. 8 (9), pp. e1186-e1194. https://doi.org/10.1016/S2214-109X(20)30286-2
Changes in disease burden in Poland between 1990–2017 in comparison with other Central European countries: A systematic analysis for the Global Burden of Disease Study 2017
Gańczak, M, Miazgowski, T, Kożybska, M, Kotwas, A, Korzeń, M, Rudnicki, B, Nogal, T, Andrei, C L, Ausloos, M, Banach, M, Brazinova, A, Constantin, M, Dubljanin, E, Herteliu, C, Hostiuc, M, Hostiuc, S, Jakovljevic, M, Jozwiak, J J, Kissimova-Skarbek, K, Król, Z J, Mestrovic, T, Miazgowski, B, Milevska Kostova, N, Naghavi, M, Negoi, I, Negoi, R I, Pana, A, Rubino, S, Sekerija, M, Sierpinski, R, Szponar, L, Topor-Madry, R, Vujcic, I S, Widecka, J, Widecka, K, Wojtyniak, B, Zadnik, V and Kopec, J A (2020). Changes in disease burden in Poland between 1990–2017 in comparison with other Central European countries: A systematic analysis for the Global Burden of Disease Study 2017. PLoS ONE. 15 (3), pp. e0226766-e0226766. https://doi.org/10.1371/journal.pone.0226766
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017
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Health sector spending and spending on HIV/AIDS, tuberculosis, and malaria, and development assistance for health: progress towards Sustainable Development Goal 3
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Liquidity transmission and the subprime mortgage crisis: a multivariate GARCH approach
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Sustainable consumption behaviours in P2P accommodation platforms: an exploratory study
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Mapping child growth failure across low- and middle-income countries
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Intriguing behavior when testing the impact of quotation marks usage in Google search results
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The influence of Lent on marriages and conceptions explored through a new methodology
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