Systematic Evaluation of Somatic Cis-Regulatory Mutations in Follicular Lymphoma
Conference paper
Firat U., Bewicke-Copley, F., Anene, C., Schlesner, M., Icgc MMML-Seq Project3, Siebert, R., Okosun, J., Fitzgibbon, J. and Wang, J (2020). Systematic Evaluation of Somatic Cis-Regulatory Mutations in Follicular Lymphoma. American Society of Hematology. https://doi.org/10.1182/blood-2020-142623
Authors | Firat U., Bewicke-Copley, F., Anene, C., Schlesner, M., Icgc MMML-Seq Project3, Siebert, R., Okosun, J., Fitzgibbon, J. and Wang, J |
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Type | Conference paper |
Abstract | Follicular lymphoma (FL) is an incurable indolent B cell malignancy characterized in the majority of cases by the t(14;18) translocation. While the mutational landscape of the coding genome is nearing completion, less is known about the characteristics of its noncoding genome. Our expectation is that the distribution of noncoding mutations will be non-random, determined by epigenomics features, such as chromatin modification and accessibility. Our strategy is therefore to integrate whole genome epigenomic marks and mutations in order to enrich for variants with regulatory potential and identify unique mutational processes specific to thesecis-regulatory elements (CREs).Allele-specific expression (ASE) patterns allow further refinement to resolve functional CREs and bona fide mutations associated with changes in gene expression. |
Year | 2020 |
Publisher | American Society of Hematology |
Journal citation | 136 (Supplement 1) |
ISSN | 0006-4971 |
Digital Object Identifier (DOI) | https://doi.org/10.1182/blood-2020-142623 |
Web address (URL) | https://ashpublications.org/blood/article/136/Supplement%201/26/472598/Systematic-Evaluation-of-Somatic-Cis-Regulatory |
Accepted author manuscript | License File Access Level Open |
Publication dates | |
20 Nov 2020 | |
Publication process dates | |
Deposited | 30 Jun 2022 |
Additional information | This research was originally published in Blood. Firat Uyulur, MSc, Findlay Bewicke-Copley, PhD MSc, BSc, Chinedu Anthony Anene, PhD, Matthias Schlesner, PhD, Icgc MMML-Seq Project, Reiner Siebert, Prof. Dr. MD, Jessica Okosun, MD PhD, Jude Fitzgibbon, PhD, Jun Wang, PhD. Systematic Evaluation of Somatic Cis-Regulatory Mutations in Follicular Lymphoma. Blood. 2020;Vol:136, Supplement 1. © the American Society of Hematology |
https://openresearch.lsbu.ac.uk/item/8zyq8
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Accepted author manuscript
Uyulur, F., Bewicke-Copley, F., Anene, C.A., Schlesner, M., Icgc, M.M.M.L., Siebert, R., Okosun, J., Fitzgibbon, J. and Wang, J., 2020.docx | ||
License: CC BY-NC 4.0 | ||
File access level: Open |
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