The role of CAF derived exosomal microRNAs in the tumour microenvironment of melanoma

Journal article

Shelton, M., Anene, C., Nsengimana, J., Roberts, W., Newton-Bishop, J. and Boyne, J.R. (2020). The role of CAF derived exosomal microRNAs in the tumour microenvironment of melanoma. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1875 (1), p. 188456. https://doi.org/10.1016/j.bbcan.2020.188456
AuthorsShelton, M., Anene, C., Nsengimana, J., Roberts, W., Newton-Bishop, J. and Boyne, J.R.
Abstract

Exosomes play a crucial role in the crosstalk between cancer associated fibroblasts (CAFs) and cancer cells, contributing to carcinogenesis and the tumour microenvironment. Recent studies have revealed that CAFs, normal fibroblasts and cancer cells all secrete exosomes that contain miRNA, establishing a cell-cell communication network within the tumour microenvironment. For example, miRNA dysregulation in melanoma has been shown to promote CAF activation via induction of epithelial-mesenchymal transition (EMT), which in turn alters the secretory phenotype of CAFs in the stroma. This review assesses the roles of melanoma exosomal miRNAs in CAF formation and how CAF exosome-mediated feedback signalling to melanoma lead to tumour progression and metastasis. Moreover, efforts to exploit exosomal miRNA-mediated network communication between tumour cells and their microenvironment, and their potential as prognostic biomarkers or novel therapeutic targets in melanoma will also be considered.

KeywordsMelanoma; Cancer associated fibroblasts; Exosomes; Micro-RNA; Metastasis
Year2020
JournalBiochimica et Biophysica Acta (BBA) - Reviews on Cancer
Journal citation1875 (1), p. 188456
PublisherElsevier
ISSN0304-419X
Digital Object Identifier (DOI)https://doi.org/10.1016/j.bbcan.2020.188456
Web address (URL)https://www.sciencedirect.com/science/article/abs/pii/S0304419X2030175X?via%3Dihub
Publication dates
Print01 Jan 2021
Online22 Oct 2022
Publication process dates
Accepted15 Oct 2022
Deposited30 Jun 2022
Accepted author manuscript
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Open
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Shelton, M., Anene, C.A., Nsengimana, J., Roberts, W., Newton-Bishop, J. and Boyne, J.R., 2021.pdf
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