Molecular Effects of Alcohol on Iron Metabolism

Book chapter


Mehta, K, Farnaud, S and Patel, VB (2016). Molecular Effects of Alcohol on Iron Metabolism. in: Molecular Aspects of Alcohol and Nutrition: A Volume in the Molecular Nutrition Series Academic Press. pp. 355-368
AuthorsMehta, K, Farnaud, S and Patel, VB
Abstract

© 2016 Elsevier Inc. All rights reserved. This chapter explores the link between iron and alcohol metabolism. Chronic alcohol consumption alters the expression of numerous iron-related proteins, including the liver-secreted systemic iron-regulator hepcidin. Downregulation of hepcidin is the key reason for increased duodenal iron absorption, which causes high circulating and stored iron levels in alcoholics, similar to that attained in hereditary hemochromatosis. The resultant free-iron mediated cytotoxicity is a common determinant of the pathophysiology of cirrhosis, an advanced liver condition observed in both alcoholic liver disease (ALD), and congenital hemochromatosis. Often, alcohol consumption suppresses hematopoiesis and/or hinders normal erythrocyte maturation, which results in anemia. Due to these alcohol-induced changes in iron metabolism, several iron-related biomarkers, like serum levels of ferritin and the glycosylation status of transferrin, are used to detect ALD. Also, modulation of hepcidin expression has been explored as a therapy to limit duodenal iron absorption and thereby restrain the tissue injury mediated by excess iron.

Page range355-368
Year2016
Book titleMolecular Aspects of Alcohol and Nutrition: A Volume in the Molecular Nutrition Series
PublisherAcademic Press
Edition1
ISBN9780128010037
Publication dates
Print01 Jan 2016
Publication process dates
Deposited12 Nov 2018
Digital Object Identifier (DOI)doi:10.1016/B978-0-12-800773-0.00028-8
Accepted author manuscript
License
CC BY 4.0
Permalink -

https://openresearch.lsbu.ac.uk/item/87563

Accepted author manuscript

  • 1
    total views
  • 0
    total downloads
  • 1
    views this month
  • 0
    downloads this month

Related outputs

A Novel Human Neuronal Cell Model to Study Iron Accumulation in Parkinson’s Disease
Mehta, K, Ahmed, B and Farnaud, S (2019). A Novel Human Neuronal Cell Model to Study Iron Accumulation in Parkinson’s Disease. Journal of Alzheimers Disease & Parkinsonism. 9 (1), p. 461.
Measurement of 4-hydroxynonenal (4-HNE) protein adducts by ELISA
Mehta, K and Patel, V (2019). Measurement of 4-hydroxynonenal (4-HNE) protein adducts by ELISA. in: Hancock, John and Conway, Myra (ed.) Redox-Mediated Signal Transduction: Methods and Protocols, Methods in Molecular Biology, vol. 1990 Springer Science+Business Media, LLC, part of Springer Nature 2019.
Thyroid Hormone Receptor (TR): a regulator in Liver Fibrogenesis
Manka, P, Coombes, JD, Bechmann, L, Swiderska-Syn, M, Reid, D, Claridge, LC, Younis, R, Mehta, K, Briones, MA, Kitamura, N, Mi, Z, Kuo, PC, Williams, R, Eksteen, B, Diehl, AM, Gerken, G, Canbay, A, Flamant, F, Gauthier, K and Syn, WK (2016). Thyroid Hormone Receptor (TR): a regulator in Liver Fibrogenesis. Fibrogenesis. New York 01 - 02 Jan 2016 doi:https://www.doi.org/10.1055/s-0036-1597375
Iron and liver fibrosis: mechanistic and clinical aspects
Mehta, K, Farnaud, S and Sharp, P A (2019). Iron and liver fibrosis: mechanistic and clinical aspects. World Journal of Gastroenterology. 25 (5), pp. 521-538.
Betaine, in context.
Mehta, K and Patel, V (2015). Betaine, in context. in: Preedy, V (ed.) Betaine: Chemistry, Analysis, Function and Effects The Royal Society of Chemistry.
Molecular and cellular insights into iron regulation
Mehta, K (2012). Molecular and cellular insights into iron regulation. PhD Thesis University of Westminster School of Life Sciences
Oxidative Stress in Iron-toxicity of Liver
Mehta, K (2018). Oxidative Stress in Iron-toxicity of Liver. in: Patel, V (ed.) The Liver: Oxidative stress and dietary antioxidants Elsevier. pp. 43-54
Iron Enhances Hepatic Fibrogenesis and Activates Transforming Growth Factor-β Signaling in Murine Hepatic Stellate Cells.
Mehta, K, Coombes, JD, Briones-Orta, M, Manka, PP, Williams, R, Patel, VB and Syn, W-K (2018). Iron Enhances Hepatic Fibrogenesis and Activates Transforming Growth Factor-β Signaling in Murine Hepatic Stellate Cells. American Journal of the Medical Sciences. 355 (2), pp. 183-190.
Characterisation of hepcidin response to holotransferrin treatment in CHO TRVb-1 cells
Mehta, K, Greenwell, P, Renshaw, D, Busbridge, M, Garcia, M, Farnaud, S and Patel, VB (2015). Characterisation of hepcidin response to holotransferrin treatment in CHO TRVb-1 cells. Blood Cells, Molecules, and Diseases. 55 (2), pp. 110-118.
Characterization of hepcidin response to holotransferrin in novel recombinant TfR1 HepG2 cells
Mehta, K, Busbridge, M, Renshaw, D, Evans, RW, Farnaud, S and Patel, VB (2016). Characterization of hepcidin response to holotransferrin in novel recombinant TfR1 HepG2 cells. Blood Cells, Molecules, and Diseases. 61, pp. 37-45.
HFE mRNA expression is responsive to intracellular and extracellular iron loading: short communication
Mehta, K, Farnaud, S and Patel, VB (2017). HFE mRNA expression is responsive to intracellular and extracellular iron loading: short communication. Molecular Biology Reports. 44 (5), pp. 399-403.
Erratum to: HFE mRNA expression is responsive to intracellular and extracellular iron loading: short communication
Mehta, K, Farnaud, S and Patel, VB (2017). Erratum to: HFE mRNA expression is responsive to intracellular and extracellular iron loading: short communication. Molecular Biology Reports. 44 (5), pp. 405-405.
Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease
Riva, A, Patel, V, Kurioka, A, Jeffery, HC, Wright, G, Tarff, S, Shawcross, D, Ryan, JM, Evans, A, Azarian, S, Bajaj, JS, Fagan, A, Patel, V, Mehta, K, Lopez, C, Simonova, M, Katzarov, K, Hadzhiolova, T, Pavlova, S, Wendon, JA, Oo, YH, Klenerman, P, Williams, R and Chokshi, S (2017). Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease. Gut. 67 (5), pp. 918-930.
Case Studies: Effects of Beef, Whey and Carbohydrate Supplementation in Female Master Triathletes
Mehta, K, Seijo, M, Larumbe-Zabala, E, Ashrafi, N, Christides, T, Karsten, B, Nielsen, BV and Naclerio, F (2018). Case Studies: Effects of Beef, Whey and Carbohydrate Supplementation in Female Master Triathletes. Journal of Human Sport and Exercise. 14 (1), pp. 170-184.