Cost-effectiveness of a preferred intensity exercise programme for young people with depression compared with treatment as usual: An economic evaluation alongside a clinical trial in the UK

Journal article

Turner, D, Carter, T, Sach, T, Guo, B and Callaghan, P (2017). Cost-effectiveness of a preferred intensity exercise programme for young people with depression compared with treatment as usual: An economic evaluation alongside a clinical trial in the UK. BMJ Open. 7 (11), pp. e016211-e016211. https://doi.org/10.1136/bmjopen-2017-016211
AuthorsTurner, D, Carter, T, Sach, T, Guo, B and Callaghan, P
Abstract

© 2017 BMJ Publishing Group. All Rights Reserved. Objectives To assess the cost-effectiveness of preferred intensity exercise programme for young people with depression compared with a treatment as usual control group. Design A ‘within trial’ cost-effectiveness and cost-utility analysis conducted alongside a randomised controlled trial. The perspective of the analysis was the UK National Health Service and social services. setting The intervention was provided in a community leisure centre setting. Participants 86 young people aged 14–17 years attending Tier 2 and Tier 3 CAMHS (Child and Adolescent Mental Health Services) outpatient services presenting with depression. Interventions The intervention comprised 12 separate sessions of circuit training over a 6-week period. Sessions were supervised by a qualified exercise therapist. Participants also received treatment as usual. The comparator group received treatment as usual. results We found improvements in the Children’s Depression Inventory-2 (CDI-2) and estimated cost-effectiveness at £61 per point improvement in CDI-2 for the exercise group compared with control. We found no evidence that the exercise intervention led to differences in quality-adjusted life years (QALY). QALYs were estimated using the EQ-5D-5L (5-level version of EuroQol-5 dimension). conclusions There is evidence that exercise can be an effective intervention for adolescents with depression and the current study shows that preferred intensity exercise could also represent a cost-effective intervention in terms of the CDI-2.

KeywordsHumans; Exercise Therapy; Single-Blind Method; Depression; Quality-Adjusted Life Years; Quality of Life; Adolescent; Cost-Benefit Analysis; Female; Male; United Kingdom
Year2017
JournalBMJ Open
Journal citation7 (11), pp. e016211-e016211
ISSN2044-6055
Digital Object Identifier (DOI)https://doi.org/10.1136/bmjopen-2017-016211
Publication dates
Print01 Jan 2017
Publication process dates
Deposited16 Jul 2019
Accepted26 Nov 2017
Publisher's version
License
File Access Level
Open
Permalink -

https://openresearch.lsbu.ac.uk/item/870z4

Download files

Publisher's version
Cost-effectiveness of a preferred intensity exercise programme for young people with depression compared with treatment as usual: an economic evaluation alongside a clinical trial in the UK.pdf
License: CC BY 4.0
File access level: Open

  • 469
    total views
  • 156
    total downloads
  • 202
    views this month
  • 0
    downloads this month

Export as

Related outputs

Study Protocol: Evaluating artificial intelligence-driven stress echocardiography analysis system (EASE study): mixed method study.
Mahdavi, M., Thomas, N., Flood, C., Stewart-Lord, A., Baillie, L., Grisan, E., Callaghan, P., Panayotova, R, Hothi, S, Griffith, V., Jayadev, S. and Frings, D. Study Protocol: Evaluating artificial intelligence-driven stress echocardiography analysis system (EASE study): mixed method study. BMJ Open.
Evaluation of a novel co‐designed and co‐delivered training package to de‐escalate violence and aggression in UK acute inpatient, PICU and forensic mental health settings
Grundy, A., Papastravrou Brooks, C., Johnston, I., Cree, L., Callaghan, P. and Price, O. (2024). Evaluation of a novel co‐designed and co‐delivered training package to de‐escalate violence and aggression in UK acute inpatient, PICU and forensic mental health settings. Journal of psychiatric and mental health nursing. https://doi.org/10.1111/jpm.13074
Development and evaluation of a de-escalation training intervention in adult acute and forensic units: the EDITION systematic review and feasibility trial.
Price, O., Papastavrou Brooks, C., Johnston, I., McPherson, P., Goodman, H., Grundy, A., Cree, L., Motala, Z., Robinson, J., Doyle, M., Stokes, N., Armitage, C., Barley, E., Brooks, H., Callaghan, P., Carter, L., Davies, L., Drake, R., Lovell, K. and Bee, P. (2024). Development and evaluation of a de-escalation training intervention in adult acute and forensic units: the EDITION systematic review and feasibility trial. Health Technology Assessment. 28 (3), pp. 1-120. https://doi.org/10.3310/FGGW6874
Clinician experiences on training and awareness of sexual orientation in NHS Talking Therapies Services for Anxiety and Depression
Ho, J.KH., O'Rourke, C, Lavalle, A, Chellingsworth, M and Callaghan, P. (2023). Clinician experiences on training and awareness of sexual orientation in NHS Talking Therapies Services for Anxiety and Depression. The Cognitive Behaviour Therapist. 16 (24), pp. 1-28. https://doi.org/10.1017/S1754470X23000181
The effect of exercise on resilience, its mediators and moderators, in a general population during the UK COVID-19 pandemic in 2020: a cross-sectional online study.
Lancaster, Molly Rose and Callaghan, P. (2022). The effect of exercise on resilience, its mediators and moderators, in a general population during the UK COVID-19 pandemic in 2020: a cross-sectional online study. BMC Public Health. 22 (1), p. 827. https://doi.org/10.1186/s12889-022-13070-7
The impact of care experience prior to commencing pre-registration nurse education and training: A scoping review.
Field-Richards, S.E., Aubeeluck, A., Callaghan, P., Keeley, P., Redsell, S.A., Spiby, H., Stacey, G. and Lymn, J.S. (2022). The impact of care experience prior to commencing pre-registration nurse education and training: A scoping review. Nurse Education Today. 120, p. 105625. https://doi.org/10.1016/j.nedt.2022.105625
Psychometric Properties of the Five Facets Mindfulness Questionnaire in Moderate-to-Severe, Persistent Depression
Sweeney, T, Morriss, R, Nixon, E, Guo, B. and Callaghan, P. (2021). Psychometric Properties of the Five Facets Mindfulness Questionnaire in Moderate-to-Severe, Persistent Depression. Mindfulness. 12, pp. 1009-1021. https://doi.org/10.1007/s12671-020-01573-6
Saudi service users' perceptions and experiences of the quality of their mental health care provision in the Kingdom of Saudi Arabia (KSA): A qualitative inquiry.
Al Mousa, Y., Callaghan, P., Michail, M. and Caswell, G. (2020). Saudi service users' perceptions and experiences of the quality of their mental health care provision in the Kingdom of Saudi Arabia (KSA): A qualitative inquiry. International journal of mental health nursing. 30 (1), pp. 300-3016. https://doi.org/10.1111/inm.12784
Evaluation of Mental Health First Aid from the Perspective Of Workplace End UseRs-EMPOWER: protocol of cluster randomised trial phase.
Atanda, O., Callaghan, P., Carter, T., Durcan, G., O'Shea, N., Brown, S. D., Reavey, P., Vangeli, E., White, S. and Wood, K. (2020). Evaluation of Mental Health First Aid from the Perspective Of Workplace End UseRs-EMPOWER: protocol of cluster randomised trial phase. Trials. 21 (1), p. 715. https://doi.org/10.1186/s13063-020-04636-0
Training to enhance user and carer involvement in mental health-care planning: the EQUIP research programme including a cluster RCT
Lovell, K., Bee, P., Bower, P., Brooks, H., Cahoon, P., Callaghan, P., Cater, L-A., Cree, L., Davies, L., Drake, R., Fraser, C., Gibbons, C., Grundy, A., Hinsliff-Smith, K., Meade, O., Roberts, C., Rogers, A., Rushton, K., Sanders, C., Shields, G. and Walker, L. (2019). Training to enhance user and carer involvement in mental health-care planning: the EQUIP research programme including a cluster RCT. Southampton Programme Grants for Applied Research. https://doi.org/10.3310/pgfar07090
Behavioural activation therapy for post-stroke depression: the BEADS feasibility RCT
Thomas, S., Drummond, A., Lincoln, N., Palmer, R., das Nair, R., Latimer, N., Hackney, G., Mandefield, L., Walters, S., Hatton, R., Cooper, C., Chater, T., England, R., Callaghan, P., Coates, E., Sutherland, K., Eshtan, S.J. and Topcu, G. (2019). Behavioural activation therapy for post-stroke depression: the BEADS feasibility RCT. National Institute for Health Research. https://doi.org/10.3310/hta23470
A pragmatic randomised controlled trial of preferred intensity exercise in depressed adult women in the United Kingdom: secondary analysis of individual variability of depression
Callaghan, P, Morres, I, Hinton-Bayre, A, Motakis, E and Carter, T (2019). A pragmatic randomised controlled trial of preferred intensity exercise in depressed adult women in the United Kingdom: secondary analysis of individual variability of depression. BMC Public Health. 19 (941), pp. 1-11. https://doi.org/10.1186/s12889-019-7238-7
Violence risk assessment and management in mental health: a conceptual, empirical and practice critique
Callaghan, P and Grundy, A (2018). Violence risk assessment and management in mental health: a conceptual, empirical and practice critique. Journal of Mental Health Training, Education and Practice. 13 (1), pp. 3-13. https://doi.org/10.1108/JMHTEP-04-2017-0027
An exploration of predictors of children's nurses' attitudes, knowledge, confidence and clinical behavioural intentions towards children and young people who self-harm.
Carter, T, Latif, A, Callaghan, P and Manning, JC (2018). An exploration of predictors of children's nurses' attitudes, knowledge, confidence and clinical behavioural intentions towards children and young people who self-harm. Journal of Clinical Nursing. 27 (13-14), pp. 2836-2846. https://doi.org/10.1111/jocn.14361
The concept of compassion within UK media generated discourse: a corpus informed analysis
Bond, C, Stacey, G, Lymn, J, Redsell, S, Spiby, H, Callaghan, P and Keeley, P (2018). The concept of compassion within UK media generated discourse: a corpus informed analysis. Journal of Clinical Nursing. https://doi.org/10.1111/jocn.14496
Embedding shared decision-making in the care of patients with severe and enduring mental health problems: The EQUIP pragmatic cluster randomised trial.
Lovell, K, Bee, P, Brooks, H, Cahoon, P, Callaghan, P, Carter, L-A, Cree, L, Davies, L, Drake, R, Fraser, C, Gibbons, C, Grundy, A, Hinsliff-Smith, K, Meade, O, Roberts, C, Rogers, A, Rushton, K, Sanders, C, Shields, G, Walker, L and Bower, P (2018). Embedding shared decision-making in the care of patients with severe and enduring mental health problems: The EQUIP pragmatic cluster randomised trial. PLoS ONE. 13 (8). https://doi.org/10.1371/journal.pone.0201533
The feasibility of nurse-delivered, low-intensity cognitive behavioural therapy for irritable bowel syndrome
Dainty, A., Hunt, M., Holtham, E., Kinsella, P., Timmons, S., Fox, M. and Callaghan, P. (2017). The feasibility of nurse-delivered, low-intensity cognitive behavioural therapy for irritable bowel syndrome. Gastrointestinal Nursing. 15 (9). https://doi.org/10.12968/gasn.2017.15.9.39
EQUIP training the trainers: an evaluation of a training programme for service users and carers involved in training mental health professionals in user-involved care planning
Fraser, C, Grundy, A, Meade, O, Callaghan, P and Lovell, K (2017). EQUIP training the trainers: an evaluation of a training programme for service users and carers involved in training mental health professionals in user-involved care planning. Journal of psychiatric and mental health nursing. 24 (6), pp. 367-376. https://doi.org/10.1111/jpm.12361
Qualitative process evaluation of a psycho-educational intervention targeted at people diagnosed with schizophrenia and their primary caregivers in Jordan
Al-HadiHasan, A, Callaghan, P and Lymn, JS (2017). Qualitative process evaluation of a psycho-educational intervention targeted at people diagnosed with schizophrenia and their primary caregivers in Jordan. BMC Psychiatry. 17 (1). https://doi.org/10.1186/s12888-017-1225-2
Evaluation of a co-delivered training package for community mental health professionals on service user- and carer-involved care planning
Grundy, AC, Walker, L, Meade, O, Fraser, C, Cree, L, Bee, P, Lovell, K and Callaghan, P (2017). Evaluation of a co-delivered training package for community mental health professionals on service user- and carer-involved care planning. Journal of psychiatric and mental health nursing. 24 (6), pp. 358-366. https://doi.org/10.1111/jpm.12378
"Our Care through our eyes": impact of a co-produced digital education programme on nurses’ knowledge, confidence and attitudes in providing care for children and young people who have self-harmed: a mixed-methods study in the UK
Manning, JC, Carter, T, Latif, A, Cooper, J, Horsley, A, Armstrong, M, Crew, J, Wood, D, Callaghan, P and Wharrad, H (2017). "Our Care through our eyes": impact of a co-produced digital education programme on nurses’ knowledge, confidence and attitudes in providing care for children and young people who have self-harmed: a mixed-methods study in the UK. BMJ Open. 7 (4). https://doi.org/10.1136/bmjopen-2016-014750
Monitoring oral health of people in Early Intervention for Psychosis (EIP) teams: The extended Three Shires randomised trial
Adams, C, Clark-Wells, N, Clifton, A, Jones, H, Simpson, J, Tosh, G, Callaghan, P, Liddle, P, Guo, B, Furtado, V, Khokar, MA and Aggarwal, VR (2017). Monitoring oral health of people in Early Intervention for Psychosis (EIP) teams: The extended Three Shires randomised trial. International Journal of Nursing Studies. 77, pp. 106-114. https://doi.org/10.1016/j.ijnurstu.2017.10.005
Exploring Students’ Participation in Universal, Depression and Anxiety, Prevention Programmes at School: A Meta-aggregation
Bastounis, A, Callaghan, P, Lykomitrou, F, Aubeeluck, A and Michail, M (2017). Exploring Students’ Participation in Universal, Depression and Anxiety, Prevention Programmes at School: A Meta-aggregation. School Mental Health. 9 (4), pp. 372-385. https://doi.org/10.1007/s12310-017-9230-7
Evaluating and Quantifying User and Carer Involvement in Mental Health Care Planning (EQUIP): Co-Development of a New Patient-Reported Outcome Measure
Bee, P, Gibbons, C, Callaghan, P, Fraser, C and Lovell, K (2016). Evaluating and Quantifying User and Carer Involvement in Mental Health Care Planning (EQUIP): Co-Development of a New Patient-Reported Outcome Measure. PLoS ONE. 11 (3), pp. e0149973-e0149973. https://doi.org/10.1371/journal.pone.0149973
The effect of exercise on depressive symptoms in adolescents: a systematic review and meta-analysis
Carter, T, Morres, I, Meade, O and Callaghan, P (2016). The effect of exercise on depressive symptoms in adolescents: a systematic review and meta-analysis. Journal of the American Academy of Child and Adolescent Psychiatry. 55 (7), pp. 580-590. https://doi.org/10.1016/j.jaac.2016.04.016
The effectiveness of the Penn Resiliency Programme (PRP) and its adapted versions in reducing depression and anxiety and improving explanatory style: A systematic review and meta-analysis
Bastounis, A, Callaghan, P, Banerjee, A and Michail, M (2016). The effectiveness of the Penn Resiliency Programme (PRP) and its adapted versions in reducing depression and anxiety and improving explanatory style: A systematic review and meta-analysis. Journal of Adolescence. 52, pp. 37-48. https://doi.org/10.1016/j.adolescence.2016.07.004
Behavioural activation therapy for depression after stroke (BEADS): a study protocol for a feasibility randomised controlled pilot trial of a psychological intervention for post-stroke depression
Thomas, SA, Coates, E, Nair, RD, Lincoln, N, Cooper, C, Palmer, R, Walters, SJ, Latimer, NR, England, TJ, Mandefield, L, Chater, T, Callaghan, P and Drummond, AER (2016). Behavioural activation therapy for depression after stroke (BEADS): a study protocol for a feasibility randomised controlled pilot trial of a psychological intervention for post-stroke depression. Pilot and Feasibility Studies. 2 (1), pp. 45/1-45/12. https://doi.org/10.1186/s40814-016-0072-0
The impact of advertising patient and public involvement on trial recruitment: embedded cluster randomised recruitment trial
Hughes-Morley, A, Hann, M, Fraser, C, Meade, O, Lovell, K, Young, B, Roberts, C, Cree, L, More, D, O’Leary, N, Callaghan, P, Waheed, W and Bower, P (2016). The impact of advertising patient and public involvement on trial recruitment: embedded cluster randomised recruitment trial. Trials. 17 (1). https://doi.org/10.1186/s13063-016-1718-1
A cluster randomised controlled trial and process evaluation of a training programme for mental health professionals to enhance user involvement in care planning in service users with severe mental health issues (EQUIP): Study protocol for a randomised controlled trial
Bower, P, Roberts, C, O'Leary, N, Callaghan, P, Bee, P, Fraser, C, Gibbons, C, Olleveant, N, Rogers, A, Davies, L, Drake, R, Sanders, C, Meade, O, Grundy, A, Walker, L, Cree, L, Berzins, K, Brooks, H, Beatty, S, Cahoon, P, Rolfe, A and Lovell, K (2015). A cluster randomised controlled trial and process evaluation of a training programme for mental health professionals to enhance user involvement in care planning in service users with severe mental health issues (EQUIP): Study protocol for a randomised controlled trial. Trials. 16 (1), pp. 348-. https://doi.org/10.1186/s13063-015-0896-6
Preferred intensity exercise for adolescents receiving treatment for depression: a pragmatic randomised controlled trial
Carter, T., Guo, B., Turner, D., Morres, I., Khalil, E., Brighton, E., Armstrong, M. and Callaghan, P. (2015). Preferred intensity exercise for adolescents receiving treatment for depression: a pragmatic randomised controlled trial. BMC Psychiatry. 15 (1), pp. 247-. https://doi.org/10.1186/s12888-015-0638-z
Evaluation of the impact of a psycho-educational intervention for people diagnosed with schizophrenia and their primary caregivers in Jordan: A randomized controlled trial
Hasan, AA, Callaghan, P and Lymn, JS (2015). Evaluation of the impact of a psycho-educational intervention for people diagnosed with schizophrenia and their primary caregivers in Jordan: A randomized controlled trial. BMC Psychiatry. 15 (1), pp. 72-. https://doi.org/10.1186/s12888-015-0444-7
Managing preconceived expectations: mental health service users experiences of going home from hospital: a grounded theory study
Keogh, B, Callaghan, P and Higgins, A (2015). Managing preconceived expectations: mental health service users experiences of going home from hospital: a grounded theory study. Journal of psychiatric and mental health nursing. 22 (9), pp. 715-723. https://doi.org/10.1111/jpm.12265
Bringing meaning to user involvement in mental health care planning: a qualitative exploration of service user perspectives
Grundy, AC, Bee, P, Meade, O, Callaghan, P, Beatty, S, Olleveant, N and Lovell, K (2015). Bringing meaning to user involvement in mental health care planning: a qualitative exploration of service user perspectives. Journal of psychiatric and mental health nursing. 23 (1), pp. 12-21. https://doi.org/10.1111/jpm.12275
Evaluation of the impact of a psycho-educational intervention on knowledge levels and psychological outcomes for people diagnosed with Schizophrenia and their caregivers in Jordan: A randomized controlled trial
Hasan, AA, Callaghan, P and Lymn, JS (2014). Evaluation of the impact of a psycho-educational intervention on knowledge levels and psychological outcomes for people diagnosed with Schizophrenia and their caregivers in Jordan: A randomized controlled trial. BMC Psychiatry. 14 (1), pp. 17-. https://doi.org/10.1186/1471-244X-14-17
A mixed methods feasibility study to evaluate the use of a low-intensity, nurse-delivered cognitive behavioural therapy for the treatment of irritable bowel syndrome
Dainty, AD, Fox, M, Lewis, N, Hunt, M, Holtham, E, Timmons, S, Kinsella, P, Wragg, A and Callaghan, P (2014). A mixed methods feasibility study to evaluate the use of a low-intensity, nurse-delivered cognitive behavioural therapy for the treatment of irritable bowel syndrome. BMJ Open. 4 (6), pp. e005262-e005262. https://doi.org/10.1136/bmjopen-2014-005262
‘We have got the tools’: Qualitative evaluation of a mental health Wellness Recovery Action Planning (WRAP) education programme in Ireland
Keogh, B, Higgins, A, DeVries, J, Morrissey, J, Callaghan, P, Ryan, D, Gijbels, H and Nash, M (2014). ‘We have got the tools’: Qualitative evaluation of a mental health Wellness Recovery Action Planning (WRAP) education programme in Ireland. Journal of psychiatric and mental health nursing. 21 (3), pp. 189-196. https://doi.org/10.1111/jpm.12068
The strengths based approach as a service delivery model for severe mental illness: a meta-analysis of clinical trials
Ibrahim, N, Michail, M and Callaghan, P (2014). The strengths based approach as a service delivery model for severe mental illness: a meta-analysis of clinical trials. BMC Psychiatry. 14 (1). https://doi.org/10.1186/s12888-014-0243-6
An oral health intervention for people with serious mental illness (Three Shires Early Intervention Dental Trial): study protocol for a randomised controlled trial
Jones, H.F., Adams, C.E., Clifton, A., Simpson, J., Tosh, G., Liddle, P.F., Callaghan, P., Yang, M., Guo, B. and Furtado, V. (2013). An oral health intervention for people with serious mental illness (Three Shires Early Intervention Dental Trial): study protocol for a randomised controlled trial. Trials. 14 (1), pp. 158/1-158/8. https://doi.org/10.1186/1745-6215-14-158
The effectiveness of a preferred intensity exercise programme on the mental health outcomes of young people with depression: A sequential mixed methods evaluation
Carter, T, Callaghan, P, Khalil, E and Morres, I (2012). The effectiveness of a preferred intensity exercise programme on the mental health outcomes of young people with depression: A sequential mixed methods evaluation. BMC Public Health. 12 (1), pp. 187-. https://doi.org/10.1186/1471-2458-12-187
Pragmatic randomised controlled trial of preferred intensity exercise in women living with depression
Callaghan, P, Khalil, E, Morres, I and Carter, T (2011). Pragmatic randomised controlled trial of preferred intensity exercise in women living with depression. BMC Public Health. 11 (1), pp. 465-. https://doi.org/10.1186/1471-2458-11-465
A Review of the Nurse Consultant Role
Callaghan, P. and Gamble, C. (2009). A Review of the Nurse Consultant Role. Nottinghamshire Healthcare NHS Foundation Trust.