Acute Psychophysiological Responses to Cyclic Variation of Intermittent Hypoxic Exposure in Adults with Obesity

Journal article


Hobbins, L, Girard, O, Gaoua, N and Hunter, S (2019). Acute Psychophysiological Responses to Cyclic Variation of Intermittent Hypoxic Exposure in Adults with Obesity. High Altitude Medicine and Biology.
AuthorsHobbins, L, Girard, O, Gaoua, N and Hunter, S
Abstract

Hobbins, Liam, Olivier Girard, Nadia Gaoua, and Steve Hunter. Acute psychophysiological responses to cyclic variation of intermittent hypoxic exposure in adults with obesity. High Alt Med Biol 00:000-000, 2019. Background: We compared acute psychophysiological responses with a single intermittent hypoxic exposure (IHE)/normoxic exposure trial with varying cycle lengths in adults with obesity. Materials and Methods: Eight obese adults (body mass index = 33.0 ± 2.2 kg/m2) completed three 60-minute IHE trials (passive seating), separated by 7 days. Trials comprised 30-minute hypoxia/30-minute normoxia (inspired oxygen fraction = 12.0%/20.9%) over Short (15 × 2/2 minutes), Medium (10 × 3/3 minutes), and Long (5 × 6/6 minutes) hypoxic/normoxic cycles and a control trial (60-minute normoxia). Results: Arterial oxygen saturation was lower during hypoxic periods of Long versus Medium and Short trials (90.1% vs. 93.0% and 94.2%; p = 0.02 and p = 0.05), with no differences between Short and Medium. Prefrontal cortex oxygenation was lower (-5.1%) during all IHE interventions versus control (p < 0.02), independent of cycle length. Perceived breathlessness was unaffected during IHE but increased 15 minutes after exposure versus baseline (+34%; p = 0.04). Breathlessness was lowest after Short versus control from 15 to 60 minutes (-7%; p = 0.01). Conclusions: When implementing IHE, greater desaturation is observed during longer compared with shorter hypoxic/normoxic cycles in adults with obesity. However, IHE tends to be better tolerated perceptually with shorter rather than longer cycles.

Keywordsacute hypoxia; obesity; perception; tissue oxygenation
Year2019
JournalHigh Altitude Medicine and Biology
ISSN1527-0297
Digital Object Identifier (DOI)doi:10.1089/ham.2019.0002
Publication dates
Print28 Jun 2019
Publication process dates
Deposited16 Jul 2019
Accepted28 Jun 2019
Accepted author manuscript
License
CC BY 4.0
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https://openresearch.lsbu.ac.uk/item/8660x

Accepted author manuscript

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