Variable structure based control strategy for treatment of HCV infection

Journal article


Hamza, A., Uneeb, M., Ahmad, I., Saleem, K. and Ali, Z. (2024). Variable structure based control strategy for treatment of HCV infection. Biomedical Signal Processing and Control. 89, p. 105803. https://doi.org/10.1016/j.bspc.2023.105803
AuthorsHamza, A., Uneeb, M., Ahmad, I., Saleem, K. and Ali, Z.
Abstract

Hepatitis C is such a harmful disease which can lead to serious health problems and it is caused by the Hepatitis C Virus (HCV) which causes liver inflammation and sometimes liver cancer. In this work, the control treatment strategy for HCV infection has been proposed. The advanced nonlinear dynamical mathematical model of HCV that has two control inputs and three state variables such as virions, infected hepatocytes and uninfected hepatocytes are considered for controller design in this research work. Moreover, four nonlinear controllers such as the Fractional Order Terminal Sliding Mode Controller (FOTSMC), Integral Terminal Sliding Mode Controller (ITSMC), Double Integral Sliding Mode Controller (DISMC) and Integral Sliding Mode Controller (ISMC) have been proposed in this work for HCV infection control inside the human body. In order to control the amount of uninfected hepatocytes to its required maximum safe limit, controllers are designed for antiviral therapy in which the amount of virions and infected hepatocytes are tracked to zero. One control input is ribavirin which blocks virions production and the other is pegylated interferon (peg-IFN-a) that acts as reducing infected hepatocytes. By doing so, uninfected hepatocytes increase and achieve the required maximum safe limit. To prove the stability of the whole system, Lyapunov stability analysis is used in this work. Simulation results and comparative analysis are carried out by using MATLAB/Simulink. It can be depicted from the given results that the virions and infected hepatocytes are reduced to their required levels completely using FOTSMC and the Sustained Virologic Response (SVR) rate is also enhanced in it. It reduces the treatment period as compared to previous strategies introduced in the literature and also system behaves very nicely even in the presence of un-modeled disturbances.

KeywordsHepatitis C VirusIntegral Sliding Mode Controller (ISMC)Double Integral Sliding Mode Controller (DISMC)Integral Terminal Sliding Mode Controller (ITSMC)Fractional Order Terminal Sliding Mode Controller (FOTSMC)
Year2024
JournalBiomedical Signal Processing and Control
Journal citation89, p. 105803
PublisherElsevier
ISSN1746-8108
Digital Object Identifier (DOI)https://doi.org/10.1016/j.bspc.2023.105803
Web address (URL)https://www.sciencedirect.com/science/article/pii/S1746809423012363
Publication dates
Print30 Nov 2023
Publication process dates
Accepted30 Nov 2023
Deposited16 Feb 2024
Publisher's version
License
File Access Level
Open
Accepted author manuscript
License
File Access Level
Controlled
Permalink -

https://openresearch.lsbu.ac.uk/item/964yz

Download files


Publisher's version
1-s2.0-S1746809423012363-main (1).pdf
License: CC BY 4.0
File access level: Open

  • 26
    total views
  • 15
    total downloads
  • 1
    views this month
  • 0
    downloads this month

Export as

Related outputs

Deep Learning Stack LSTM Based MPPT Control of Dual Stage 100 kWp Grid-Tied Solar PV System
Umair Y., Ahmet A.K. and Ali, Z. (2024). Deep Learning Stack LSTM Based MPPT Control of Dual Stage 100 kWp Grid-Tied Solar PV System. IEEE Access. 12, pp. 77555-77574. https://doi.org/10.1109/ACCESS.2024.3407605
Modified Flower Pollination Algorithm for Energy Forecasting and Demand Management Coupled with Improved Battery Life for Smart Building Micro-Grid
Hamza, Ali, Ali, Zunaib, Dudley, Sandra, Uneeb, Muhammad, Alghamdi, Sultan M and Christofides, Nicholas (2024). Modified Flower Pollination Algorithm for Energy Forecasting and Demand Management Coupled with Improved Battery Life for Smart Building Micro-Grid. 2024 IEEE Texas Power and Energy Conference (TPEC). https://doi.org/10.1109/tpec60005.2024.10472245
Distribution Substation Dynamic Reconfiguration and Reinforcement-Digital Twin Model
Brown, R., Wickramarachchi, W., Ali, Z., Saleem, K. and Dudley-Mcevoy, S. (2023). Distribution Substation Dynamic Reconfiguration and Reinforcement-Digital Twin Model. IEEE Energy Conversion Congress and Exposition (ECCE). Center in Nashville, Tennessee | October 29 – November 2, 2023 29 Oct - 02 Nov 2023 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ECCE53617.2023.10362160
Modeling and Experimental Investigation of Energy Management for Hybrid Electric Vehicle based on Variable Structure Control Strategy
Ali H., Muhammad U., Saleem K. and Ali Z. (2023). Modeling and Experimental Investigation of Energy Management for Hybrid Electric Vehicle based on Variable Structure Control Strategy. 2023 IEEE International Conference on Energy Technologies for Future Grids (ETFG). Wollongong, Australia 03 - 06 Dec 2023 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ETFG55873.2023.10408458
Multiobjective Optimized Smart Charge Controller for Electric Vehicle Applications
Ali, Z., Putrus, G., Marzband, M., Gholinejad, H., Saleem, K. and Subudhi, B. (2023). Multiobjective Optimized Smart Charge Controller for Electric Vehicle Applications. IEEE Transactions on Industry Applications. 58 (5), pp. 5602-5615. https://doi.org/10.1109/TIA.2022.3164999
Variable Structure-Based Control for Dynamic Temperature Setpoint Regulation in Hospital Extreme Healthcare Zones
Hamza, A., Uneeb, M., Ahmad, I., Saleem, K. and Ali, Z. (2023). Variable Structure-Based Control for Dynamic Temperature Setpoint Regulation in Hospital Extreme Healthcare Zones. Energies. 16 (10), p. 4223. https://doi.org/10.3390/en16104223
Forecasting Global Solar Insolation Using the Ensemble Kalman Filter Based Clearness Index Model
Ray, P. K., Subudhi, B., Putrus, G., Marzband, M. and Ali, Z. (2022). Forecasting Global Solar Insolation Using the Ensemble Kalman Filter Based Clearness Index Model. IEEE CSEE Journal of Power and Energy Systems. 8 (4), pp. 1087-1096. https://doi.org/10.17775/CSEEJPES.2021.06230
Microgrid Cyberphysical Systems ; Chapter 5 - Control of PV and EV connected smart grid
Ali, Z., Saleem, K., Putrus, G., Marzband, M. and Dudley-Mcevoy, S. (2022). Microgrid Cyberphysical Systems ; Chapter 5 - Control of PV and EV connected smart grid. in: Subudhi, B. (ed.) Elsevier Renewable Energy and Plug-In Vehicle Integration Elsevier Renewable Energy and Plug-In Vehicle Integration.
Performance Analysis and Benchmarking of PLL-Driven Phasor Measurement Units for Renewable Energy Systems
Ali, Z., Saleem, K., Brown, R., Christofides, N. and Dudley-Mcevoy, S. (2022). Performance Analysis and Benchmarking of PLL-Driven Phasor Measurement Units for Renewable Energy Systems. Energies. 15 (5), p. e1867. https://doi.org/10.3390/en15051867
Micro market based optimisation framework for decentralised management of distributed flexibility assets
Paladin, A., Das, R., Wang, Y., Ali, Z., Kotter, R., Putrus, G. and Turri, R. (2021). Micro market based optimisation framework for decentralised management of distributed flexibility assets. Renewable Energy. 163, pp. 1595-1611. https://doi.org/10.1016/j.renene.2020.10.003
On Beneficial Vehicle-to-Grid (V2G) Services
Bentley, E., Putrus, G., Lacey, G., Kotter, R., Wang, Y., Das R,, Ali, Z. and Warmerdam, J. (2021). On Beneficial Vehicle-to-Grid (V2G) Services. 2021 9th International Conference on Modern Power Systems (MPS). Cluj-Napoca, Romania 16 - 17 Jun 2021 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/MPS52805.2021.9492671
Heuristic Multi-Agent Control for Energy Management of Microgrids with Distributed Energy Sources
Ali, Z., Putrus, G., Marzband, M., Tookanlou, M.B., Saleem, K., Ray, P.K. and Subudhi, B. (2021). Heuristic Multi-Agent Control for Energy Management of Microgrids with Distributed Energy Sources. 2021 56th International Universities Power Engineering Conference (UPEC). Middlesborough 31 Aug - 03 Sep 2021 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/UPEC50034.2021.9548152
A single-phase synchronization technique for grid-connected energy storage system under faulty grid conditions
Saleem, K., Ali, Z. and K. Mehran (2021). A single-phase synchronization technique for grid-connected energy storage system under faulty grid conditions. IEEE Transactions on Power Electronics. 36 (10), pp. 12019-12032. https://doi.org/10.1109/TPEL.2021.3071418
Enhancement of flexibility in multi-energy microgrids considering voltage and congestion improvement: Robust thermal comfort against reserve calls
Kazemi-Razi, S.M., Abyaneh, H.A., Nafisi, H., Ali, Z. and Marzband, M. (2021). Enhancement of flexibility in multi-energy microgrids considering voltage and congestion improvement: Robust thermal comfort against reserve calls. Sustainable Cities and Society. 74, p. 103160. https://doi.org/10.1016/j.scs.2021.103160
Online Sensorless Solar Power Forecasting for Microgrid Control and Automation
Ali, Z., Putrus, G., Marzband, M., Tookanlou, M., Saleem, K., Ray, P. and Subudhi, B. (2021). Online Sensorless Solar Power Forecasting for Microgrid Control and Automation. 2021 International Symposium of Asian Control Association on Intelligent Robotics and Industrial Automation (IRIA). Goa, India 20 - 22 Sep 2021 IEEE. https://doi.org/10.1109/IRIA53009.2021.9588690
Online reduced complexity parameter estimation technique for equivalent circuit model of lithium-ion battery
Saleem, K., Mehran, K. and Ali, Z. (2020). Online reduced complexity parameter estimation technique for equivalent circuit model of lithium-ion battery. Electric Power Systems Research. 185, p. 106356. https://doi.org/10.1016/j.epsr.2020.106356
An improved pre-filtering moving average filter based synchronization algorithm for single-phase V2G application
Saleem, K., Mehran, K. and Ali, Z. (2020). An improved pre-filtering moving average filter based synchronization algorithm for single-phase V2G application. 2020 IEEE Energy Conversion Congress and Exposition (ECCE). Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ECCE44975.2020.9236406
Autonomous energy management system with self-healing capabilities for green buildings (microgrids)
Mansour Selseleh, Jonban, Romeral, Luis, Akbarimajd, Adel, Ali, Zunaib, Seyedeh Samaneh, Ghazimirsaeid, Marzband, Mousa and Putrus, Ghanim, Jonban, M.S., Romeral, L., Akbarimajd, A., Ali, Z., Ghazimirsaeid, S.S., Marzband, M. and Putrus, G. (2020). Autonomous energy management system with self-healing capabilities for green buildings (microgrids). Journal of Building Engineering. 34, p. 101604. https://doi.org/10.1016/j.jobe.2020.101604
Diversifying the Role of Distributed Generation Grid-Side Converters for Improving the Power Quality of Distribution Networks Using Advanced Control Techniques
Ali, Z., Christofides, N., Hadjidemetriou, L. and Kyriakides, E. (2019). Diversifying the Role of Distributed Generation Grid-Side Converters for Improving the Power Quality of Distribution Networks Using Advanced Control Techniques. IEEE Transactions on Industry Applications. 55 (4), pp. 4110-4123. https://doi.org/10.1109/TIA.2019.2904678
Three-phase phase-locked loop synchronization algorithms for grid-connected renewable energy systems: A review
Ali, Z., Christofides, N., Hadjidemetriou, L., Kyriakides, E., Yang, Y. and Blaabjerg, F. (2018). Three-phase phase-locked loop synchronization algorithms for grid-connected renewable energy systems: A review. Renewable and Sustainable Energy Reviews. 90, pp. 434-452. https://doi.org/10.1016/j.rser.2018.03.086