Variable structure based control strategy for treatment of HCV infection

Journal article


Hamza, A., Uneeb, M., Ahmad, I., Saleem, K. and Ali, Z. (2024). Variable structure based control strategy for treatment of HCV infection. Biomedical Signal Processing and Control. 89, p. 105803. https://doi.org/10.1016/j.bspc.2023.105803
AuthorsHamza, A., Uneeb, M., Ahmad, I., Saleem, K. and Ali, Z.
Abstract

Hepatitis C is such a harmful disease which can lead to serious health problems and it is caused by the Hepatitis C Virus (HCV) which causes liver inflammation and sometimes liver cancer. In this work, the control treatment strategy for HCV infection has been proposed. The advanced nonlinear dynamical mathematical model of HCV that has two control inputs and three state variables such as virions, infected hepatocytes and uninfected hepatocytes are considered for controller design in this research work. Moreover, four nonlinear controllers such as the Fractional Order Terminal Sliding Mode Controller (FOTSMC), Integral Terminal Sliding Mode Controller (ITSMC), Double Integral Sliding Mode Controller (DISMC) and Integral Sliding Mode Controller (ISMC) have been proposed in this work for HCV infection control inside the human body. In order to control the amount of uninfected hepatocytes to its required maximum safe limit, controllers are designed for antiviral therapy in which the amount of virions and infected hepatocytes are tracked to zero. One control input is ribavirin which blocks virions production and the other is pegylated interferon (peg-IFN-a) that acts as reducing infected hepatocytes. By doing so, uninfected hepatocytes increase and achieve the required maximum safe limit. To prove the stability of the whole system, Lyapunov stability analysis is used in this work. Simulation results and comparative analysis are carried out by using MATLAB/Simulink. It can be depicted from the given results that the virions and infected hepatocytes are reduced to their required levels completely using FOTSMC and the Sustained Virologic Response (SVR) rate is also enhanced in it. It reduces the treatment period as compared to previous strategies introduced in the literature and also system behaves very nicely even in the presence of un-modeled disturbances.

KeywordsHepatitis C VirusIntegral Sliding Mode Controller (ISMC)Double Integral Sliding Mode Controller (DISMC)Integral Terminal Sliding Mode Controller (ITSMC)Fractional Order Terminal Sliding Mode Controller (FOTSMC)
Year2024
JournalBiomedical Signal Processing and Control
Journal citation89, p. 105803
PublisherElsevier
ISSN1746-8108
Digital Object Identifier (DOI)https://doi.org/10.1016/j.bspc.2023.105803
Web address (URL)https://www.sciencedirect.com/science/article/pii/S1746809423012363
Publication dates
Print30 Nov 2023
Publication process dates
Accepted30 Nov 2023
Deposited16 Feb 2024
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