How may shorter fractionation schedules affect patient care

This session aims to explore the use of hypofractionation in the radiotherapy management of different cancer types and how this ultimately can affect patient care. Hypofractionation has shown to be beneficial in the management of a wide range of cancers including other advantages such as cost savings3. Trials over the last decade have demonstrated
the advantages of hypofractionation compared with a standard radiotherapy regimen3. Covid-19 significantly impacted the way in which cancer patients are managed and even though the
use of hypofractionation is well established in some cancer types; the application thereof during the pandemic has been widely expanded to minimise treatment time. Even though the treatment outcomes have been well defined, there is limited evidence to suggest changes in patient care.
Some oncology centres advocated for a reduced contact time between patient and staff. Hypofractionation in an ageing population is particularly advantageous in allowing people to receive treatment in a shorter time demonstrating treatment outcomes similar to younger age groups however; greater consideration should be given to performance status and comorbidities associated with these treatment outcomes11. Fractionation schedules which allow delivery in less fractions, can be highly effective with limited treatment-related toxicity. Studies have shown that the late
consequences of radiotherapy in these patient groups are seldom an issue even with larger fraction sizes. However more recent studies suggest that a reduction in treatment time should not be the only reason for selecting this approach. Moderate hypofractionation should therefore be
considered for those patient who are younger and who might experience long terms effects. More studies are now investigating the tolerability of ultra-hypofractionated radiotherapy in an attempt to improve the therapeutic gain in the management of cancer suggesting that these approaches are
well-tolerated and showed no statistical difference in toxicity.
Hypofractionation in radiotherapy may be a good alternative to conventional fractionation however patience care remains paramount in the management of all toxicities related the radiotherapy delivery. There is no evidence to suggest the patient care of these patients have changed, however
the tolerability and outcomes of this method of delivery requires constant review. Patient care needs to consider the site of treatment, age of the patient, performance status, and tolerability. A model of shared decision making in managing care is advocated with greater emphasis on self-care.