Reducing risk of overdose with midazolam injection in adults: an evaluation of change in clinical practice to improve patient safety in England
Journal article
Flood, C, Matthew, L, Marsh, R, Patel, B, Mansaray, M and Lamont, T (2014). Reducing risk of overdose with midazolam injection in adults: an evaluation of change in clinical practice to improve patient safety in England. Journal of Evaluation in Clinical Practice. 21 (1), pp. 57-66. https://doi.org/10.1111/jep.12228
Authors | Flood, C, Matthew, L, Marsh, R, Patel, B, Mansaray, M and Lamont, T |
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Abstract | Rationale aims and objectives. This study sought to evaluate potential reductions in risk associated with midazolam injection, a sedating medication, following a United Kingdom National Patient Safety Alert. This alert, ?Reducing risk of overdose with midazolam injection in adults?, was sent to all National Health Service organisations as a Rapid Response Report detailing actions services should take to minimise risks. Method. To evaluate any potential changes arising from this alert, a number of data sources were explored including reported incidents to a national reporting system for health care error, clinician survey and audit data, pharmaceutical purchasing patterns and feedback from NHS managers. Results. Prior to the Rapid Response Report, 498 incidents were received by the National Patient Safety Agency including 3 deaths. Post implementation of the Rapid Response Report (June 2009), no incidents resulting in death or severe harm had been received. All organisations reported having completed the Rapid Response Report actions. Purchase and use of risk-prone, high-strength sedating midazolam by health care organisations decreased significantly as did the increased use of safer, lower strength doses (as recommended in the Rapid Response Report). Conclusions. Organisations can achieve safer medication practices, better knowledge, awareness and implementation of national safer practice recommendations. Risks from inadvertent overdose of midazolam injection was reduced post implementation of national recommendations. Ongoing monitoring of this particular adverse event will be required with a sustained patient safety message to health services to maintain awareness of the issue and reduction in the number of midazolam related errors. |
Keywords | Humans; Flumazenil; Midazolam; Hypnotics and Sedatives; Antidotes; Medication Errors; Injections; Health Knowledge, Attitudes, Practice; Risk Reduction Behavior; Safety Management; Dose-Response Relationship, Drug; State Medicine; England; Patient Safety; Drug Overdose |
Year | 2014 |
Journal | Journal of Evaluation in Clinical Practice |
Journal citation | 21 (1), pp. 57-66 |
Publisher | Wiley |
ISSN | 1356-1294 |
Digital Object Identifier (DOI) | https://doi.org/10.1111/jep.12228 |
Web address (URL) | http://openaccess.city.ac.uk/4515/ |
Publication dates | |
11 Aug 2014 | |
Publication process dates | |
Deposited | 22 May 2019 |
Accepted | 16 Jun 2014 |
Accepted author manuscript | License |
https://openresearch.lsbu.ac.uk/item/877x3
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Reducing risk of overdose with midazolam injection in adults.pdf | ||
License: CC BY-NC 4.0 |
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