Selected B vitamins and their possible link to the aetiology of age-related sarcopenia: relevance of UK dietary recommendations.

Journal article


Aytekin, N, Mileva, K. and Cunliffe, AD (2018). Selected B vitamins and their possible link to the aetiology of age-related sarcopenia: relevance of UK dietary recommendations. Nutrition Research Reviews. 31 (2), pp. 104-224. https://doi.org/10.1017/S0954422418000045
AuthorsAytekin, N, Mileva, K. and Cunliffe, AD
Abstract

The possible roles of selected B vitamins in the development and progression of sarcopenia are reviewed. Age-related declines in muscle mass and function are associated with huge and increasing costs to healthcare providers. Falls and loss of mobility and independence due to declining muscle mass/function are associated with poor clinical outcomes and their prevention and management are attractive research targets. Nutritional status appears a key modifiable and affordable intervention. There is emerging evidence of sarcopenia being the result not only of diminished anabolic activity but also of declining neurological integrity in older age, which is emerging as an important aspect of the development of age-related decline in muscle mass/function. In this connection, several B vitamins can be viewed as not only cofactors in muscle synthetic processes, but also as neurotrophic agents with involvements in both bioenergetic and trophic pathways. The B vitamins thus selected are examined with respect to their relevance to multiple aspects of neuromuscular function and evidence is considered that requirements, intakes or absorption may be altered in the elderly. In addition, the evidence base for recommended intakes (UK recommended daily allowance) is examined with particular reference to original datasets and their relevance to older individuals. It is possible that inconsistencies in the literature with respect to the nutritional management of sarcopenia may, in part at least, be the result of compromised micronutrient status in some study participants. It is suggested that in order, for example, for intervention with amino acids to be successful, underlying micronutrient deficiencies must first be addressed/eliminated.

This article has been accepted for publication and will
appear in a revised form, subsequent to peer review and/or editorial input by Cambridge University Press, in Nutrition Research Reviews published by Cambridge University Press

KeywordsAgeing: B vitamin intake; Micronutrient status; Neurological integrity; Neuromuscular function; Recommended daily intake; Sarcopenia; 07 Agricultural And Veterinary Sciences; 11 Medical And Health Sciences; 06 Biological Sciences; Nutrition & Dietetics
Year2018
JournalNutrition Research Reviews
Journal citation31 (2), pp. 104-224
PublisherCambridge University Press
ISSN1475-2700
Digital Object Identifier (DOI)https://doi.org/10.1017/S0954422418000045
Web address (URL)https://www.cambridge.org/core/journals/nutrition-research-reviews/article/selected-b-vitamins-and-their-possible-link-to-the-aetiology-of-agerelated-sarcopenia-relevance-of-uk-dietary-recommendations/10ED903913C62F166993E45B4E721326
Publication dates
Online09 May 2018
Print01 Dec 2018
Publication process dates
Deposited20 Aug 2018
Accepted09 May 2018
Accepted author manuscript
License
File Access Level
Open
Page range1-21
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