Selected B vitamins and their possible link to the aetiology of age-related sarcopenia: relevance of UK dietary recommendations.

Journal article


Aytekin, N, Mileva, K. and Cunliffe, AD (2018). Selected B vitamins and their possible link to the aetiology of age-related sarcopenia: relevance of UK dietary recommendations. Nutrition Research Reviews. 31 (2), pp. 104-224. https://doi.org/10.1017/S0954422418000045
AuthorsAytekin, N, Mileva, K. and Cunliffe, AD
Abstract

The possible roles of selected B vitamins in the development and progression of sarcopenia are reviewed. Age-related declines in muscle mass and function are associated with huge and increasing costs to healthcare providers. Falls and loss of mobility and independence due to declining muscle mass/function are associated with poor clinical outcomes and their prevention and management are attractive research targets. Nutritional status appears a key modifiable and affordable intervention. There is emerging evidence of sarcopenia being the result not only of diminished anabolic activity but also of declining neurological integrity in older age, which is emerging as an important aspect of the development of age-related decline in muscle mass/function. In this connection, several B vitamins can be viewed as not only cofactors in muscle synthetic processes, but also as neurotrophic agents with involvements in both bioenergetic and trophic pathways. The B vitamins thus selected are examined with respect to their relevance to multiple aspects of neuromuscular function and evidence is considered that requirements, intakes or absorption may be altered in the elderly. In addition, the evidence base for recommended intakes (UK recommended daily allowance) is examined with particular reference to original datasets and their relevance to older individuals. It is possible that inconsistencies in the literature with respect to the nutritional management of sarcopenia may, in part at least, be the result of compromised micronutrient status in some study participants. It is suggested that in order, for example, for intervention with amino acids to be successful, underlying micronutrient deficiencies must first be addressed/eliminated.

This article has been accepted for publication and will
appear in a revised form, subsequent to peer review and/or editorial input by Cambridge University Press, in Nutrition Research Reviews published by Cambridge University Press

KeywordsAgeing: B vitamin intake; Micronutrient status; Neurological integrity; Neuromuscular function; Recommended daily intake; Sarcopenia; 07 Agricultural And Veterinary Sciences; 11 Medical And Health Sciences; 06 Biological Sciences; Nutrition & Dietetics
Year2018
JournalNutrition Research Reviews
Journal citation31 (2), pp. 104-224
PublisherCambridge University Press (CUP)
ISSN1475-2700
Digital Object Identifier (DOI)https://doi.org/10.1017/S0954422418000045
Web address (URL)https://www.cambridge.org/core/journals/nutrition-research-reviews/article/selected-b-vitamins-and-their-possible-link-to-the-aetiology-of-agerelated-sarcopenia-relevance-of-uk-dietary-recommendations/10ED903913C62F166993E45B4E721326
Publication dates
Online09 May 2018
Print01 Dec 2018
Publication process dates
Deposited20 Aug 2018
Accepted09 May 2018
Accepted author manuscript
License
File Access Level
Open
Page range1-21
Permalink -

https://openresearch.lsbu.ac.uk/item/86qyw

Download files


Accepted author manuscript
Aytekin_NRR_2018.doc
License: CC BY 4.0
File access level: Open

  • 189
    total views
  • 220
    total downloads
  • 0
    views this month
  • 1
    downloads this month

Export as

Related outputs

Impact of different mechanical and metabolic stimuli on the temporal dynamics of muscle strength adaptation
Lambrianides, Y., Epro, G., Smith, K., Mileva, K., James, D. and Karamanidis, K. (2022). Impact of different mechanical and metabolic stimuli on the temporal dynamics of muscle strength adaptation. Journal of strength and conditioning research. 36 (11), pp. 3246-3255. https://doi.org/10.1519/JSC.0000000000004300
The Type of Per-Cooling Strategies Currently Employed by Competitive and Professional Cyclists-Triathletes During Training and Competition Are Condition (Dry vs. Humid) Dependant
Bayne, F., Racinais, S., Mileva, K.N., Hunter, S. and Gaoua, N. (2022). The Type of Per-Cooling Strategies Currently Employed by Competitive and Professional Cyclists-Triathletes During Training and Competition Are Condition (Dry vs. Humid) Dependant. Frontiers in Sports and Active Living. 4, p. 845427. https://doi.org/10.3389/fspor.2022.845427
Integrated multi-omics of the gut microbiome: assessing the beneficial effects of fermented foods to human health
Bester, A., Toribio-Mateas, M., Mileva, K. and Gaoua, N. (2022). Integrated multi-omics of the gut microbiome: assessing the beneficial effects of fermented foods to human health. Exploring Human Host-Microbiome Interactions in Health and Disease. Hinxton, Cambridge 05 - 07 Dec 2018 Wellcome Connecting Science Courses and Conferences. https://doi.org/10.13140/RG.2.2.10244.58246
Sport and Exercise Science and Health
Mileva, K. and Zaidell, L. (2022). Sport and Exercise Science and Health. in: Wills, J. (ed.) Health Studies: an Introduction Springer Nature. pp. 84-124
What makes young people get involved with street gangs in London? A study of the perceived risk factors
Annan, L., Gaoua, N., Mileva, K. and Borges, M. (2021). What makes young people get involved with street gangs in London? A study of the perceived risk factors. Journal of Community Psychology. https://doi.org/10.1002/jcop.22767
A voluntary activation deficit in m. abductor hallucis exists in asymptomatic feet.
Perez Olivera, A., Solan, M.C, Karamanidis, K., Mileva, K.N. and James, D. (2021). A voluntary activation deficit in m. abductor hallucis exists in asymptomatic feet. Journal of Biomechanics. 130, p. 110863. https://doi.org/10.1016/j.jbiomech.2021.110863
Gastrocnemius medialis contractile behavior during running differs between simulated Lunar and Martian gravities
Richter, Ch., Braunstein B., Staeudle B., Attias J., Suess A., Weber T., Mileva, K., Rittweger J., Green D.A. and Albracht K. (2021). Gastrocnemius medialis contractile behavior during running differs between simulated Lunar and Martian gravities. Scientific Reports. 11 (22555). https://doi.org/10.1038/s41598-021-00527-9
Contractile behavior of the gastrocnemius medialis muscle during running in simulated hypogravity
Richter, C., Braunstein, B., Staeudle, B., Attias, J., Suess, A., Weber, T., Mileva, K., Rittweger, J., Green, D.A. and Albracht, K. (2021). Contractile behavior of the gastrocnemius medialis muscle during running in simulated hypogravity. NPJ microgravity. 7 (32), pp. 1-8. https://doi.org/10.1038/s41526-021-00155-7
This Girl Can, can't she? Perspectives from exercise providers and participants on what factors influence participation  
Hull, R., Zaidell, L., Mileva, K. and De Oliveira, R. (2021). This Girl Can, can't she? Perspectives from exercise providers and participants on what factors influence participation  . Psychology of Sport and Exercise. 57, p. 102043. https://doi.org/10.1016/j.psychsport.2021.102043
Gastrocnemius Medialis Contractile Behavior Is Preserved During 30% Body Weight Supported Gait Training
Richter, C., Braunstein, B., Staeudle, B., Attias, J., Suess, A., Weber, T., Mileva, K.N., Rittweger, J., Green, D.A. and Albracht, K. (2021). Gastrocnemius Medialis Contractile Behavior Is Preserved During 30% Body Weight Supported Gait Training. Frontiers in Sports and Active Living. 2. https://doi.org/10.3389/fspor.2020.614559
Less Is More—Cyclists-Triathlete’s 30 min Cycling Time-Trial Performance Is Impaired With Multiple Feedback Compared to a Single Feedback
Bayne, F., Racinais, Sebastien, Mileva, Katya, Hunter, Steve and Gaoua, Nadia (2020). Less Is More—Cyclists-Triathlete’s 30 min Cycling Time-Trial Performance Is Impaired With Multiple Feedback Compared to a Single Feedback. Frontiers in Psychology. 11, p. 608426. https://doi.org/10.3389/fpsyg.2020.608426
Supraspinal Responses and Spinal Reflexes
Mileva, K and Ritzmann, R (2020). Supraspinal Responses and Spinal Reflexes. in: Rittweger, J (ed.) Manual of Vibration Exercise and Vibration Therapy Cham, Switzerland Springer Nature. pp. 121-133
Direct muscle electrical stimulation as a method for the in vivo assessment of force production in m. abductor hallucis
Olivera, A.L.P., Alzapiedi, D.F., Solan, M.C., Karamanidis, K., Mileva, K. and James, D.C. (2020). Direct muscle electrical stimulation as a method for the in vivo assessment of force production in m. abductor hallucis. Journal of Biomechanics. 100, p. 109606. https://doi.org/10.1016/j.jbiomech.2020.109606
Training Regimes and Recovery Monitoring Practices of Elite British Swimmers
Pollock, S., Gaoua, N., Johnston, M., Cooke, K., Girard, O. and Mileva, K. (2019). Training Regimes and Recovery Monitoring Practices of Elite British Swimmers. Journal of Sports Science and Medicine. 18, pp. 577-585.
Correction to: Effect of Immobilisation on Neuromuscular Function In Vivo in Humans: A Systematic Review
Campbell, M, Varley-Campbell, J, Fulford, J, Taylor, B, Mileva, KN and Bowtell, JL (2019). Correction to: Effect of Immobilisation on Neuromuscular Function In Vivo in Humans: A Systematic Review. Sports Medicine. 49 (6), pp. 981-986. https://doi.org/10.1007/s40279-019-01100-1
Lower body acceleration and muscular responses to rotational and vertical whole-body vibration of different frequencies and amplitudes
Zaidell, L., Mileva, K., James, D.C., Bowtell, J., Pollock, R.D., Newham, D.J. and Sumners, D.P. (2019). Lower body acceleration and muscular responses to rotational and vertical whole-body vibration of different frequencies and amplitudes. Dose-Response. 17 (1). https://doi.org/10.1177/1559325818819946
Effect of Immobilisation on Neuromuscular Function In Vivoin Humans: A Systematic Review
Campbell, M, Varley-Campbell, J, Fulford, J, Taylor, B, Mileva, K. and Bowtell, J (2019). Effect of Immobilisation on Neuromuscular Function In Vivoin Humans: A Systematic Review. Sports Medicine. 49, pp. 931-950. https://doi.org/10.1007/s40279-019-01088-8
Foetal developmental origins of adult onset non-insulin dependent diabetes mellitus
Stephenson, S and Cunliffe, A (2018). Foetal developmental origins of adult onset non-insulin dependent diabetes mellitus. Journal of Nutrition and Food Sciences. 8 (5), pp. 1-11. https://doi.org/10.4172/2155-9600.1000733
Improved Exercise Tolerance with Caffeine Is Associated with Modulation of both Peripheral and Central Neural Processes in Human Participants.
Bowtell, JL, Mohr, M, Fulford, J, Jackman, SR, Ermidis, G, Krustrup, P and Mileva, K. (2018). Improved Exercise Tolerance with Caffeine Is Associated with Modulation of both Peripheral and Central Neural Processes in Human Participants. Frontiers in Nutrition. 5, p. 6. https://doi.org/10.3389/fnut.2018.00006
Melanin-concentrating hormone in peripheral circulation in the human
Naufahu, J, Brito, F, Doslikova, B, Valencia, T, Cunliffe, A and Murray, J (2017). Melanin-concentrating hormone in peripheral circulation in the human. The Journal of clinical endocrinology. 232 (3), pp. 513-523. https://doi.org/10.1530/JOE-16-0240
Muscle metabolic and neuromuscular determinants of fatigue during cycling in different exercise intensity domains.
Black, MI, Blackwell, JR, Bailey, SJ, Wylie, LJ, McDonagh, STJ, Thompson, C, Kelly, J, Sumners, P, Mileva, K., Bowtell, JL and Vanhatalo, A (2017). Muscle metabolic and neuromuscular determinants of fatigue during cycling in different exercise intensity domains. Journal of Applied Physicology (1985). 122 (3), pp. 446-459. https://doi.org/10.1152/japplphysiol.00942.2016
Effectiveness of commercial versus homemade sports drinks on fluid balance and exercise capacity during high-intensity intermittent exercise
Cunliffe, A, Begum, R, Leverrit, M and Konstantaki, M (2016). Effectiveness of commercial versus homemade sports drinks on fluid balance and exercise capacity during high-intensity intermittent exercise. American Journal of Sports Science and Medicine. 3 (2), pp. 39 - 46 (8). https://doi.org/10.12691/ajssm-3-2-3
The biomechanical characteristics of wearing FitFlop™ sandals highlight significant alterations in gait pattern: a comparative study.
James, DC, Farmer, LJ, Sayers, JB, Cook, DP and Mileva, K. (2015). The biomechanical characteristics of wearing FitFlop™ sandals highlight significant alterations in gait pattern: a comparative study. Clinical Biomechanics. 30 (4), pp. 347-354. https://doi.org/10.1016/j.clinbiomech.2015.02.016
47 An acute session of high-frequency, low-intensity, wide-pulse electrical stimulation evokes fatigue adaptations in an intrinsic foot muscle
James, DC, Mileva, K. and Solan, MC (2015). 47 An acute session of high-frequency, low-intensity, wide-pulse electrical stimulation evokes fatigue adaptations in an intrinsic foot muscle. British Journal of Sports Medicine. 49 (Suppl). https://doi.org/10.1136/bjsports-2015-095573.47
Low-frequency accelerations over-estimate impact-related shock during walking.
James, DC, Mileva, K. and Cook, DP (2014). Low-frequency accelerations over-estimate impact-related shock during walking. Journal of Electromyography and Kinesiology. 24 (2), pp. 264-270. https://doi.org/10.1016/j.jelekin.2013.12.008
Experimental evidence of the tonic vibration reflex during whole-body vibration of the loaded and unloaded leg
Zaidell, L., Mileva, K., Sumners, D.P. and Bowtell, J. (2013). Experimental evidence of the tonic vibration reflex during whole-body vibration of the loaded and unloaded leg. PLoS ONE. 8 (12), p. e85247. https://doi.org/10.1371/journal.pone.0085247
Effect of Hypohydration on Peripheral and Corticospinal Excitability and Voluntary Activation
Bowtell, JL, Avenell, G, Hunter, SP and Mileva, K. (2013). Effect of Hypohydration on Peripheral and Corticospinal Excitability and Voluntary Activation. PLoS ONE. 8 (10), p. e77004. https://doi.org/10.1371/journal.pone.0077004
Repeated sprint training in normobaric hypoxia
Cooke, K, Galvin, HM, Sumners, DP, Mileva, K. and Bowtell, JL (2013). Repeated sprint training in normobaric hypoxia. British Journal of Sports Medicine. 47, pp. i74-i79. https://doi.org/10.1136/bjsports-2013-092826
Wide-pulse electrical stimulation to an intrinsic foot muscle induces acute functional changes in forefoot-rearfoot coupling behaviour during walking.
James, D.C., Chesters, T., Sumners, D.P., Cook, D.P., Green, D.A. and Mileva, K. (2012). Wide-pulse electrical stimulation to an intrinsic foot muscle induces acute functional changes in forefoot-rearfoot coupling behaviour during walking. International Journal of Sports Medicine. 34 (5), pp. 438-443. https://doi.org/10.1055/s-0032-1321893