Effects of serotonin depletion and dopamine depletion on bimodal divided attention.
Königschulte, W, Civai, C, Hildebrand, P, Gaber, TJ, Fink, GR and Zepf, FD (2018). Effects of serotonin depletion and dopamine depletion on bimodal divided attention. World Journal of Biological Psychiatry. https://doi.org/10.1080/15622975.2018.1532110
|Authors||Königschulte, W, Civai, C, Hildebrand, P, Gaber, TJ, Fink, GR and Zepf, FD|
OBJECTIVES:This study aimed to explore the effects of acute phenylalanine-tyrosine depletion (APTD) and acute tryptophan depletion (ATD) on bimodal divided attention. A balanced amino acid mixture (BAL) served as control condition. METHODS:54 healthy adults (age: M = 23.8 years) were randomly assigned to APTD, ATD or BAL in a double-blind, between-subject approach. Divided attention was assessed after 4 hours. Blood samples were taken before and 6 hours after challenge intake. RESULTS:Amino acid concentrations following challenge intake significantly decreased (all p ≤ .01). There was a significant difference in the mean reaction time (RT) towards auditory stimuli, but not towards visual stimuli between the groups. Post-hoc comparison of mean RT's (auditory stimuli) showed a significant difference between ATD (RT = 604.0 ms, SD = 56.9 ms) and APTD (RT = 556.4 ms, SD = 54.2 ms; p = .037), but no RT-difference between ATD and BAL or APTD and BAL (RT = 573.6 ms, SD = 45.7 ms). CONCLUSIONS:The results indicate a possible dissociation between the effects of a diminished brain 5-HT and DA synthesis on the performance in a bimodal divided attention task. The difference was exclusively observed within the RT towards auditory signals.
This is an Accepted Manuscript of an article published by Taylor & Francis in the World Journal of Biological Psychiatry on 08 October 2018, available online: http://www.tandfonline.com/10.1080/15622975.2018.1532110
|Keywords||Acute tryptophan depletion; attention; dopamine; healthy volunteers; phenylalanine tyrosine depletion; serotonin; 1103 Clinical Sciences; 1109 Neurosciences; Psychiatry|
|Journal||World Journal of Biological Psychiatry|
|Digital Object Identifier (DOI)||https://doi.org/10.1080/15622975.2018.1532110|
|08 Oct 2018|
|Publication process dates|
|Deposited||03 Nov 2018|
|Accepted||02 Oct 2018|
|Accepted author manuscript|
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