Congenital Adrenal Hyperplasia
Conference presentation
Davies, K. (2024). Congenital Adrenal Hyperplasia. 2024 IMAGE meeting. Nice, France 21 - 22 Mar 2024
Authors | Davies, K. |
---|---|
Type | Conference presentation |
Abstract | CAH is the commonest form of adrenal insufficiency with an incidence of approximately 1 in 15,000. The basic defects are genetic defects in the function of several different enzymes, leading to deficient cortisol synthesis and secretion and an over-reaction of excess ACTH which stimulates the production of steroid precursors leading to excess as androgens. Androgen excess can lead to genital virilization and bone age advance. The commonest form is 21-hydroxylase deficiency. The basic challenge is to address the cortisol deficiency with glucocorticoid replacement which will lower ACTH and androgens, without causing cortisol toxicity. This a major clinical challenge. |
Keywords | CAH, adrenal, cortisol, hydrocortisone |
Year | 2024 |
Web address (URL) | https://paediatric-endocrinology.medwirenews.com/meetings/image-2024/ |
Accepted author manuscript | License File Access Level Open |
Publication dates | |
Online | 22 Mar 2024 |
Publication process dates | |
Deposited | 29 Jul 2024 |
Web address (URL) of conference proceedings | https://paediatric-endocrinology.medwirenews.com/meetings/image-2024/ |
Permalink -
https://openresearch.lsbu.ac.uk/item/97w45
Download files
22
total views11
total downloads3
views this month2
downloads this month