Pituitary volume in people with chronic schizophrenia: Clarifying the roles of serious violence and childhood maltreatment

Journal article


Premkumar, P., Bipin, M., Das, M., Lau, J. Y. F., Sumich, A. L. and Kumari, V. (2021). Pituitary volume in people with chronic schizophrenia: Clarifying the roles of serious violence and childhood maltreatment. Psychiatry Research: Neuroimaging. 314, p. 111323. https://doi.org/10.1016/j.pscychresns.2021.111323
AuthorsPremkumar, P., Bipin, M., Das, M., Lau, J. Y. F., Sumich, A. L. and Kumari, V.
Abstract

Aberrations in stress-linked hypothalamic-pituitary-adrenal axis function have been independently associated with schizophrenia, antisocial behaviour and childhood maltreatment. In this study, we examined pituitary volume (PV) in relation to childhood maltreatment (physical abuse, sexual abuse, neglect) in men (i) with schizophrenia and a history of serious violence (n = 13), (ii) with schizophrenia but without a history of serious violence (n = 15), (iii) with antisocial personality disorder (ASPD) and a history of serious violence (n = 13), and (iv) healthy participants without a history of violence (n = 15). All participants underwent whole-brain magnetic resonance imaging. Experiences of childhood maltreatment were rated based on interviews (for all), and case history and clinical/forensic records (for patients only). There was a trend for smaller PV, on average, in schizophrenia patients (regardless of a history of violence), compared to the healthy group and the ASPD group; other group differences in PV were non-significant. Sexual abuse ratings correlated negatively with PVs in ASPD participants, but no significant association between childhood maltreatment and PV was found in schizophrenia participants. Our findings are consistent with previous evidence of smaller-than-normal PV in chronic schizo- phrenia patients, and suggest that illness-related influences may mask the possible sexual abuse-smaller PV as- sociation, seen here in ASPD, in this population.

KeywordsSexual abuse; Physical abuse; Violence; MRI; Stress
Year2021
JournalPsychiatry Research: Neuroimaging
Journal citation314, p. 111323
PublisherElsevier
Digital Object Identifier (DOI)https://doi.org/10.1016/j.pscychresns.2021.111323
Web address (URL)https://authors.elsevier.com/c/1dJqc3IRiGuA4p
Publication dates
Online15 Jun 2021
Print30 Aug 2021
Publication process dates
Accepted08 Jun 2021
Deposited29 Jun 2021
Accepted author manuscript
License
File Access Level
Open
Permalink -

https://openresearch.lsbu.ac.uk/item/8x117

Restricted files

Accepted author manuscript

  • 3
    total views
  • 1
    total downloads
  • 2
    views this month
  • 0
    downloads this month

Export as

Related outputs

Mild-to-moderate schizotypal traits relate to physiological arousal from social stress
Premkumar, P., Alahakoon, P., Smith, M., Kumari, V., Babu, D. and Baker, J. (2020). Mild-to-moderate schizotypal traits relate to physiological arousal from social stress. Stress. https://doi.org/10.1080/10253890.2020.1797674
The path from schizotypy to depression and aggression and the role of family stress
Premkumar, P., Kuipers, E. and Kumiar, V. (2020). The path from schizotypy to depression and aggression and the role of family stress. European Psychiatry. 63 (1), p. e79. https://doi.org/10.1192/j.eurpsy.2020.76
Developing and maintaining the teacher-student relationship in one to one alternative provision: the tutor’s experience
Premkumar, P., Fitzsimmons, W. and Trigg, R. Developing and maintaining the teacher-student relationship in one to one alternative provision: the tutor’s experience. Educational Review. https://doi.org/10.1080/00131911.2019.1653265
Neural responses to criticism and praise vary with schizotypy and perceived emotional support
Premkumar, P., Santo, M. G. E., Onwumere, O., Schürmann, M., Kumari, V., Blanco, S., Baker, J. and Kuipers, E. (2019). Neural responses to criticism and praise vary with schizotypy and perceived emotional support. International Journal of Psychophysiology. 145, pp. 109-118. https://doi.org/10.1016/j.ijpsycho.2019.05.008
Sensitivity to criticism and praise predicts schizotypy in the non-clinical population: The role of affect and perceived expressed emotion
Premkumar, P., Dunn, A. K., Onwumere, J. and Kuipers, E. (2019). Sensitivity to criticism and praise predicts schizotypy in the non-clinical population: The role of affect and perceived expressed emotion. European Psychiatry. 55, p. 109–115. https://doi.org/10.1016/j.eurpsy.2018.10.009
Deciphering reward-based decision making in schizophrenia: a meta-analysis and behavioral modelling of the Iowa Gambling Task
Premkumar, P., Betz, Linda T, Brambilla, Paolo, Ilankovic, Andrej, Premkumar, Preethi, Kim, Myung-Sun, Raffard, Stéphane, Bayard, Sophie, Hori, Hikaru, Lee, Kyoung-Uk, Lee, Seung Jae, Koutsouleris, Nikolaos and Kambeitz, Joseph (2019). Deciphering reward-based decision making in schizophrenia: a meta-analysis and behavioral modelling of the Iowa Gambling Task. Schizophrenia Research. 204, pp. 7-15. https://doi.org/10.1016/j.schres.2018.09.009
Pituitary volume reduction in schizophrenia following cognitive behavioural therapy
Premkumar, P., Bream, D., Sapara, A., Fannon, D., Anilkumar, A. P., Kuipers, E. and Kumari.V. (2018). Pituitary volume reduction in schizophrenia following cognitive behavioural therapy. Schizophrenia Research. 192, p. 416–422. https://doi.org/10.1016/j.schres.2017.04.035
Schizotypal traits and their relation to rejection sensitivity in the general population: Their mediation by quality of life, agreeableness and neuroticism
Premkumar, P., Onwumere, J., Betts, L., Kibowski, F. and Kuipers, E. (2018). Schizotypal traits and their relation to rejection sensitivity in the general population: Their mediation by quality of life, agreeableness and neuroticism. Psychiatry Research. 267, pp. 201-209. https://doi.org/10.1016/j.psychres.2018.06.002