Improved PET/CT Respiratory Motion Compensation by Incorporating Changes in Lung Density
Journal article
Emond, E.C., Bousse, A., Brusaferri, L., Hutton, B.F. and Thielemans, K. (2020). Improved PET/CT Respiratory Motion Compensation by Incorporating Changes in Lung Density. IEEE Transactions on Radiation and Plasma Medical Sciences. pp. 594 - 602. https://doi.org/10.1109/trpms.2020.3001094
Authors | Emond, E.C., Bousse, A., Brusaferri, L., Hutton, B.F. and Thielemans, K. |
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Abstract | Positron emission tomography/computed tomography (PET/CT) lung imaging is highly sensitive to motion. Although several techniques exist to diminish motion artifacts, a few accounts for both tissue displacement and changes in density due to the compression and dilation of the lungs, which cause quantification errors. This article presents an experimental framework for joint activity image reconstruction and motion estimation in PET/CT, where the PET image and the motion are directly estimated from the raw data. Direct motion estimation methods for motion-compensated PET/CT are preferable as they require a single attenuation map only and result in optimal signal-to-noise ratio (SNR). Previous implementations, however, failed to address changes in density during respiration. We propose to account for such changes using the Jacobian determinant of the deformation fields. In a feasibility study, we demonstrate on a modified extended cardiac-torso (XCAT) phantom with breathing motion-where the lung density and activity vary-that our approach achieved better quantification in the lungs than conventional PET/CT joint activity image reconstruction and motion estimation that does not account for density changes. The proposed method resulted in lower bias and variance in the activity images, reduced mean relative activity error in the lung at the reference gate (-4.84% to -3.22%) and more realistic Jacobian determinant values. |
Year | 2020 |
Journal | IEEE Transactions on Radiation and Plasma Medical Sciences |
Journal citation | pp. 594 - 602 |
Publisher | Institute of Electrical and Electronics Engineers (IEEE) |
ISSN | 2469-7303 |
Digital Object Identifier (DOI) | https://doi.org/10.1109/trpms.2020.3001094 |
Web address (URL) | https://doi.org/10.1109/TRPMS.2020.3001094 |
Publication dates | |
Online | 09 Jul 2020 |
Publication process dates | |
Deposited | 16 Feb 2024 |
Publisher's version | License File Access Level Open |
https://openresearch.lsbu.ac.uk/item/9655v
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Publisher's version
Improved_PET_CT_Respiratory_Motion_Compensation_by_Incorporating_Changes_in_Lung_Density.pdf | ||
License: CC BY 4.0 | ||
File access level: Open |
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